A5100323004- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Neuroscience of respiration and sleep
- Cancer-related molecular mechanisms research
- Regulation of Appetite and Obesity
- Alzheimer's disease research and treatments
- Obstructive Sleep Apnea Research
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Sleep and Wakefulness Research
- High Altitude and Hypoxia
- Asthma and respiratory diseases
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Histiocytic Disorders and Treatments
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Biochemical Analysis and Sensing Techniques
- Pain Mechanisms and Treatments
- Thermoregulation and physiological responses
- Genetic factors in colorectal cancer
- Dietary Effects on Health
- Diet and metabolism studies
- Vascular Tumors and Angiosarcomas
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
China Medical University
2019-2025
Jingchu University of Technology
2025
Liaoning Cancer Hospital & Institute
2025
Dalian University of Technology
2025
Shandong University of Traditional Chinese Medicine
2024
Tianjin Medical University
2024
Beijing Radiation Center
2023
Xiangya Hospital Central South University
2015-2023
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Alzheimer's disease (AD) has become a severe medical challenge. Advances in technologies produced high-dimensional data of different modalities including functional magnetic resonance imaging (fMRI) and single nucleotide polymorphism (SNP). Understanding the complex association patterns among these heterogeneous complementary is benefit to diagnosis prevention AD. In this paper, we apply appropriate correlation analysis method detect relationships between brain regions genes, propose "brain...
Obstructive sleep apnea (OSA) has been linked to obesity, inflammation, and metabolic syndrome. The gut microbiota, which serves as reservoir for bacterial lipopolysaccharides (LPS), could be altered by OSA trigger inflammation. LPS-binding protein (LBP) a surrogate marker of underlying low-grade endotoxemia LPS from the gut. We hypothesized that systemic LBP levels would higher in obese children those with OSA. Consecutive snoring nonsnoring (mean age 6.8 ± 1.3 y) were included after...
Ferroptosis is a kind of regulated cell death, supporting the pathological process lung inflammation, including asthma. Quercetin (QCT), natural dietary flavonoid, exerts anti-inflammatory and anti-ferroptosis effects in various diseases. However, role QCT ferroptosis-associated airway inflammation neutrophilic asthma remains to be described. Our study aimed investigate therapeutic on Ferrostatin-1 (Fer-1), as ferroptosis inhibitor, was used demonstrate whether relied ferroptosis. In our...
Ferroptosis is inhibited by glutathione peroxidase 4 (GPX4), an antioxidant enzyme that uses reduced (GSH) as a cofactor to detoxify lipid hydroperoxides. As selenoprotein, the core function of GPX4 thiol-dependent redox reaction. In addition GSH, other small molecules such cysteine and homocysteine also contain thiols; yet, whether can exploit directly hydroperoxides inhibit ferroptosis has not been addressed. this study, we found in GPX4-dependent manner. However, inhibits independent GSH...
Abstract The selenium-containing enzyme GPX4 moonlights as a central regulator of ferroptosis, an iron-dependent, nonapoptotic form regulated cell death caused by lipid peroxidation. Yet, little is known about the mechanisms underlying regulation its post-transcriptional modifications. Here, we identify tripartite motif-containing protein TRIM26 E3 ubiquitin ligase GPX4. directly interacts with through Ring domain and catalyzes ubiquitination at K107 K117, which promotes switch in...
A comprehensive analysis of the structure neuronal nitric oxide synthase (nNOS; EC 1.14.13.39 ) mRNA species revealed NOS1 to be most structurally diverse human gene described date in terms promoter usage. Nine unique exon 1 variants are variously used for transcript initiation tissues, and each is expressed from a 5′-flanking region. The dependence on genomic regions control transcription cell-specific fashion burdens transcripts with complex 5′-mRNA leader sequences. Elaborate splicing...
Sleep fragmentation (SF) is highly prevalent and may constitute an important contributing factor to excessive weight gain the metabolic syndrome. Increased endoplasmic reticulum (ER) stress activation of unfolded protein response (UPR) leading attenuation leptin receptor signaling in hypothalamus leads obesity dysfunction.Mice were exposed SF sleep control (SC) for varying periods time during which ingestive behaviors monitored. UPR pathways assessed hypothalami. To further examine...
Acute respiratory distress syndrome (ARDS) is characterized by pulmonary epithelial injury and extensive inflammation of the parenchyma. Systematic analyses microRNA (miRNA) mRNA expression profiling in ARDS provide insights into understanding molecular mechanisms pathogenesis ARDS. The objective this study was to identify miRNA interactions a rat model combining microarray analyses. Rat induced saline lavage mechanical ventilation. profiles both mRNAs miRNAs were performed Microarray data...
Abstract Background Obesity-related asthma is a kind of nonallergic with excessive neutrophil infiltration in the airways. However, underlying mechanisms have been poorly elucidated. Among adipokines related to obesity, leptin inflammatory response. little understood about how acts on receptor (obR) neutrophilic airway inflammation obesity-associated asthma. We explored effects leptin/obR signaling an obesity-related mouse model. Methods established model using lipopolysaccharide...
Intermittent hypoxia (IH) is a frequent occurrence in sleep and respiratory disorders. Both human murine studies show that IH may be implicated metabolic dysfunction. Although the effects of nocturnal low-frequency intermittent (IH(L)) have not been extensively examined, it would appear IH(L) high-frequency (IH(H)) elicit distinct adaptations. To this effect, C57BL/6J mice were randomly assigned to IH(H) (cycles 90 s 6.4% O(2) 21% during daylight), (8% daylight hours), or control (CTL) for 5...
Background and Aim: Carotid atherosclerosis (CAS) is a common pathogenesis of cerebrovascular disease closely related to stroke silent (SCD), while the insufficient brain perfusion mechanism cannot quite explain mechanism. The purpose this study was utilize diffusion tensor image analysis along perivascular space (DTI-ALPS) evaluate glymphatic system activity correlated DTI-ALPS with enlarged spaces (ePVS), carotid intima-media thickening (CIMT), mini-mental state examination (MMSE),...
Overweight/obesity is a chronic disease that carries an increased risk of hypertension, diabetes mellitus, and premature death. Several epidemiological studies have demonstrated clear relationship between salt intake obesity, but the pathophysiologic mechanisms remain unknown. We hypothesized ghrelin, which regulates appetite, food intake, fat deposition, becomes elevated when one consumes high-salt diet, contributing to progression obesity. We, therefore, investigated fasting ghrelin...
Nanoparticle-induced ferroptosis has been proven to be an appealing strategy in cancer treatment. Previously, we reported the synthesis of amphiphilic polymer prodrug SO2, mPEG-PLG(DNs), which could self-assemble formulate nanoparticles (NP-DNs) and trigger cell death by GSH consumption SO2 release. In current study, potential mechanism NP-DNs-induced was further investigated. We demonstrated that NP-DNs exhibited efficient antitumor activity against gastric via ferroptosis. selectively...
Hereditary antithrombin deficiency, an autosomal-dominant thrombotic disease caused by a SERPINC1 gene is extremely rare, although it the leading cause of hereditary thrombophilias. Herein we report novel mutation in Chinese family and one case pulmonary embolism associated with mutation. We also discuss latest diagnostic treatment strategies for deficiency. The 33-year-old male proband had there was no evidence thromboembolism other members. In case, nadroparin calcium combined warfarin...