A5012061714- Antifungal resistance and susceptibility
- Enzyme function and inhibition
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Respiratory Support and Mechanisms
- Estrogen and related hormone effects
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Pulmonary Hypertension Research and Treatments
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Atrial Fibrillation Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Blood Coagulation and Thrombosis Mechanisms
- Lung Cancer Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Parasitic infections in humans and animals
- PI3K/AKT/mTOR signaling in cancer
- Peripheral Artery Disease Management
- Respiratory viral infections research
- Anorectal Disease Treatments and Outcomes
Soochow University
2016-2025
First Affiliated Hospital of Soochow University
2016-2025
Zunyi Medical University
2021-2024
Single nucleotide polymorphisms (SNPs) in microRNA‑binding sites located the 3'‑untranslated region (UTR) of target genes can have an effect on interaction microRNA‑mediated regulation, which results changes expression levels ultimately associated with cancer risk and patient prognosis. However, role SNPs at 3'‑UTR B7‑H1 susceptibility non‑small cell lung (NSCLC) remains to be fully elucidated. In present study, a minor allele frequency >10%, were microRNA complementary site PD‑L1 3'‑UTR,...
Abstract Background AKT2 is highly expressed in many human cancers, including non-small cell lung cancer (NSCLC). Accumulating evidence has also revealed that can promote NSCLC proliferation and metastasis. However, the involved mechanism remains unclear. Herein, our study mainly explored function of during progression uncovered a new post-transcriptional expression adenocarcinoma (LUAD). Methods Quantitative real-time (qRT-PCR), western blot immunohistochemistry (IHC) assays were performed...
Active mutations of the EGFR gene have been proved to predict activity EGFR-TKI. The most common are exon 19 deletion and 21 point mutation, both which sensitive However, rare or complex still exist, data scarce controversial. Their response EGFR-TKI remains uncertain. We presented a patient diagnosed with stage IV lung adenocarcinoma who was found mutation in (L747P) before any treatment. disease progressed 2 months after chemotherapy containing cisplatin pemetrexed, erlotinib administered,...
Hereditary antithrombin deficiency, an autosomal-dominant thrombotic disease caused by a SERPINC1 gene is extremely rare, although it the leading cause of hereditary thrombophilias. Herein we report novel mutation in Chinese family and one case pulmonary embolism associated with mutation. We also discuss latest diagnostic treatment strategies for deficiency. The 33-year-old male proband had there was no evidence thromboembolism other members. In case, nadroparin calcium combined warfarin...
Thromboangiitis obliterans (TAO) is one of the most common types peripheral arterial disease (PAD). This study aimed to explore characteristics top 100 cited articles in TAO.A bibliometric analysis based on Web Science (WOS) database was performed. Literature retrieved and ranked by citations. Listed below are citations, including original articles, reviews, full-length proceeding papers, case reports that were included for analysis. The type literature, research areas, languages recorded....
Torquetenovirus (TTV) was a promising biomarker for immunity, while lung regional TTV evaluating the opportunistic infection among immunocompromised hosts (ICH) unclear.
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare malignancy-related respiratory complication, demonstrating rapid progression of pulmonary hypertension (PH) and failure. Although number treatments have been attempted for patients diagnosed with or suspected having PTTM, successful-treated cases PTTM were mainly from imatinib therapy, which was PDGF receptor inhibitor. Anlotinib novel tyrosine kinase inhibitor that targets VEGFR, FGFR, PDGFR, c-kit.We reported patient associated...
Abstract Background Whether the value of PD‐L1 expression from metastatic sites to predict efficacy immune checkpoint blockade (ICB)‐based treatment is equivalent that a primary tumor uncertain. This study aimed compare utility TPS lung and overall response rate (ORR) first‐line ICB‐based treatment. Methods included 249 patients with advanced non‐small cell cancer (NSCLC) who received All subjects underwent testing prior were divided into two cohorts corresponding different biopsy sites:...
Mucormycosis is an invasive fungal infection that can result in severe lung infections, with pulmonary mucormycosis (PM) being one of the most prevalent manifestations. Prompt diagnosis crucial for patient survival, as PM often exhibits rapid clinical progression and carries a high fatality rate. Broncho-alveolar lavage fluid or endobronchial biopsy (EBB) has been commonly employed diagnosing PM, although there limited mention ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)...
Here, we report a case of adenoviral pneumonia associated with critical ARDS treated Cidofovir, prone ventilation and extracorporeal membrane oxygenation (ECMO). The patient responded well to therapy recovered without further complications. early ECMO support, may be therapeutic option for patients related pneumonia.
Background: An evaluation system is urgently needed to describe early predictors of the outcome high-flow nasal cannula (HFNC) oxygen therapy in acute hypoxemic respiratory failure (AHRF) patients. Methods: All consecutive AHRF patients a Respiratory Intensive Care Unit (RICU) receiving HFNC between January 2019 and December 2021 were enrolled. Results: Of 106 enrolled subjects, 57 (53.8%) succeeded 49 (46.2%) failed. Being male (p = 0.006), initial rate oxygenation (ROX) index 0.011), Acute...
Objective To determine the serum nonylphenol (NP) concentrations in colorectal cancer patients and healthy populations. Methods 141 who were diagnosed as served observation group (88 males with average age of 60.28 years, 53 females 64.74 years), 141 people control 61.2 63.57 years). Serum levels NP determined by high performance liquid chromatography. Results In group, neopterin [(237.27±36.93) ng/ml], [(232.65±34.87) ng/ml] both sexes significantly increased compared...