Maximiliano Tamae Kakazu

ORCID: 0000-0003-4943-1656
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About
Contact & Profiles
Research Areas
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Obstructive Sleep Apnea Research
  • Respiratory Support and Mechanisms
  • Neuroscience of respiration and sleep
  • Inhalation and Respiratory Drug Delivery
  • Transplantation: Methods and Outcomes
  • Sepsis Diagnosis and Treatment
  • Occupational exposure and asthma
  • Hematopoietic Stem Cell Transplantation
  • Mechanical Circulatory Support Devices
  • Intensive Care Unit Cognitive Disorders
  • Cardiac Arrest and Resuscitation
  • Research on Leishmaniasis Studies
  • Cystic Fibrosis Research Advances
  • Cardiovascular and Diving-Related Complications
  • Clinical Nutrition and Gastroenterology
  • Trypanosoma species research and implications
  • Bariatric Surgery and Outcomes
  • COVID-19 Clinical Research Studies
  • Trauma Management and Diagnosis
  • Hemodynamic Monitoring and Therapy
  • Tracheal and airway disorders
  • SARS-CoV-2 and COVID-19 Research
  • Pneumonia and Respiratory Infections
  • Long-Term Effects of COVID-19

Spectrum Health
2017-2025

Michigan State University
2017-2025

Michigan United
2023-2024

Corewell Health
2023-2024

Trinity Health Grand Rapids
2024

Pulmonary and Critical Care Associates
2023

Corewell Health Blodgett Hospital
2022

Grand Rapids Community College
2022

University of Chicago
2013

John H. Stroger, Jr. Hospital of Cook County
2011

Obstructive sleep apnea (OSA) has been linked to obesity, inflammation, and metabolic syndrome. The gut microbiota, which serves as reservoir for bacterial lipopolysaccharides (LPS), could be altered by OSA trigger inflammation. LPS-binding protein (LBP) a surrogate marker of underlying low-grade endotoxemia LPS from the gut. We hypothesized that systemic LBP levels would higher in obese children those with OSA. Consecutive snoring nonsnoring (mean age 6.8 ± 1.3 y) were included after...

10.1210/jc.2013-3327 article EN The Journal of Clinical Endocrinology & Metabolism 2013-11-26

Rationale: The vast majority of children around the world undergoing adenotonsillectomy for obstructive sleep apnea–hypopnea syndrome (OSA) are not objectively diagnosed by nocturnal polysomnography because access availability and cost issues. Automated analysis oximetry (nSpO2), which is readily globally available, could potentially provide a reliable convenient diagnostic approach pediatric OSA.Methods: Deidentified nSpO2 recordings from total 4,191 originating 13 laboratories were...

10.1164/rccm.201705-0930oc article EN American Journal of Respiratory and Critical Care Medicine 2017-07-31

Abstract Introduction Real-world evidence on the timing and efficacy of enteral nutrition (EN) practices in intensive care unit (ICU) patients with circulatory shock is limited. We hypothesized early EN (EEN), as compared to delayed (DEN), associated improved clinical outcomes mechanically ventilated (MV) shock. Methods analyzed a dataset from an international, multicenter, pragmatic randomized trial (RCT) evaluating protein dose ICU patients. Data were collected admission, EEN was defined...

10.1186/s13054-022-04047-4 article EN cc-by Critical Care 2022-06-09

It is unclear whether extracorporeal CO

10.1164/rccm.202311-2060oc article EN American Journal of Respiratory and Critical Care Medicine 2024-01-23

SUMMARY Inoculation of Trypanosoma cruzi, Tulahuén strain, into C57BL/6 and BALB/c mice led to an acute infection characterized by marked parasitaemia, myocardial inflammation thymocyte depletion. While showed a progressive lethal disease, partly recovered. To characterize these murine models more effectively, we studied the parasite burden, serum levels major outcome-related cytokines, in vitro features T. cruzi peritoneal macrophages immunophenotype thymic cells. The greater disease...

10.1046/j.1365-2249.2002.01874.x article EN Clinical & Experimental Immunology 2002-06-01

The cytokine-mediated stimulation of the hypothalamus–pituitary–adrenal (HPA) axis is relevant for survival during bacterial endotoxemia and certain viral infections. However, only limited information available regarding effects endogenous glucocorticoids on parasite diseases. We have studied this issue using, as a model, C57Bl/6 Balb/c mice infected with Trypanosoma cruzi , causal agent Chagas’ disease. These two mouse strains differ in susceptibility to infection parasite. An intense...

10.1677/joe.1.06642 article EN Journal of Endocrinology 2006-08-01

10.1164/ajrccm.2025.211.abstracts.a2018 article EN American Journal of Respiratory and Critical Care Medicine 2025-05-01

10.1164/ajrccm.2025.211.abstracts.a6614 article EN American Journal of Respiratory and Critical Care Medicine 2025-05-01
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