A5028788970- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Respiratory Support and Mechanisms
- Connexins and lens biology
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Nicotinic Acetylcholine Receptors Study
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging and Pathology Studies
- Renal Transplantation Outcomes and Treatments
- Pleural and Pulmonary Diseases
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Intensive Care Unit Cognitive Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Yersinia bacterium, plague, ectoparasites research
- Organ and Tissue Transplantation Research
- Airway Management and Intubation Techniques
- Venous Thromboembolism Diagnosis and Management
- Neonatal Respiratory Health Research
- Tissue Engineering and Regenerative Medicine
- Voice and Speech Disorders
- Fuel Cells and Related Materials
University of Florida
2021-2025
University of Florida Health
2025
Florida College
2021-2024
University Health Network
2020
University of Toronto
2020
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
2010-2018
Mater Misericordiae University Hospital
2017
Lithuanian University of Health Sciences
2014
Yeshiva University
2006-2007
Albert Einstein College of Medicine
2006-2007
Oculodentodigital dysplasia (ODDD) is a dominant negatively inherited disorder with variable but characteristic anomalies of the fingers and toes, eyes, face teeth, which are caused by mutations in connexin 43 (Cx43) gene. All analyzed so far have negative influence on conductance through gap junctional channels hemichannels, as well trafficking Cx43 protein transfected cells. In this study, we inserted human Cx43G138R point mutation into mouse gene generated mice conditionally expressing...
It is unclear whether extracorporeal CO
Gap junction channels are composed of two apposing hemichannels (connexons) in the contiguous cells and provide a direct pathway for electrical metabolic signaling between adjacent cells. The family connexin genes comprises 20 members mouse 21 human genome. Connexins expressed all tissues except differentiated skeletal muscle, erythrocytes, mature sperm Various express more than one type connexins; therefore, homotypic, heterotypic, heteromeric gap may form In this article, we briefly review...
For single-lumen veno-pulmonary extracorporeal membrane oxygenation (VP ECMO) cannulation in percutaneous technique, vascular ultrasound (U/S) and transesophageal echocardiography (TEE) guidance were used to insert a 7 Fr pulmonary artery catheter (PAC) an Amplatz Super Stiff (Boston Scientific) 0.035 inch × 260 cm guide wire (through the PAC) into (PA). The PAC was removed, kept position. After dilation, long flexible 19 50 single-stage ECMO cannula inserted over stiff with its tip PA, 23...
Four connexins (Cxs), mouse (m)Cx30.2, Cx40, Cx43, and Cx45, determine cell-cell electrical signaling in heart, Cx43 Cx45 are known to form unapposed hemichannels. Here we show that mCx30.2, which is most abundantly expressed sinoatrial atrioventricular nodal regions of the its putative human ortholog, (h)Cx31.9, also functional hemichannels, which, like mCx30.2 channels, permeable cationic dyes up approximately 400 Da size. DAPI uptake by HeLa cells expressing was >10-fold faster than...
We examined the permeabilities of homotypic and heterotypic gap junction (GJ) channels formed rodent connexins (Cx) 30.2, 40, 43, 45, which are expressed in heart other tissues, using fluorescent dyes differing net charge molecular mass. Combining imaging electrophysiological recordings same cell pairs, we evaluated single-channel permeability (P(gamma)). All were permeable to anionic monovalent dye Alexa Fluor-350 (AF(350)), but mCx30.2 exhibited a significantly lower P(gamma) than others....
In this case report, we present a 39-year-old patient with large space-occupying tumour of the right hemichest and anterior mediastinum. Due to size involvement lung, pneumonectomy, hemidiaphragm partial pericardial resection were completed.
Venovenous extracorporeal membrane oxygenation is the most commonly used mode of support in pre-lung transplant recipients. In patients who experience right ventricular dysfunction, venopulmonary ECMO an excellent option to preserve RV function. We retrospectively reviewed were supported with ECMO. Descriptive analysis, patient characteristics, outcomes, and survival assessed. The primary outcome was mortality. Mean age 45.5 ± 15.63, mean hours 1391.75 1239.01. 4 had dysfunction. All...
Tracheobronchomalacia is a condition of dynamic airway collapse due to weakness the tracheobronchial wall. When conservative management, including continuous positive pressure, fails control symptoms or improve quality life, surgical intervention may be warranted. In this case report, we present technique tracheobronchoplasty via right posterolateral thoracotomy in patient with severe tracheobronchomalacia.
Postintubation subglottic tracheal stenosis remains a prevalent complication in patients who require prolonged periods of intubation, with an incidence up to 11%. Transcervical resection and reconstruction remain the gold standards for definitive treatment stenotic regions that fail trials non-surgical interventions, including local steroid injections, cryotherapy balloon dilation. Despite its high success rate, it is one more technically difficult procedures thoracic surgery. In this case...