A5001724162- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Intensive Care Unit Cognitive Disorders
- Vitamin C and Antioxidants Research
- Burn Injury Management and Outcomes
- Electrolyte and hormonal disorders
- Abdominal Surgery and Complications
- Meta-analysis and systematic reviews
- Enhanced Recovery After Surgery
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin K Research Studies
- Anesthesia and Neurotoxicity Research
- Statistical Methods in Clinical Trials
- Sodium Intake and Health
- Pneumothorax, Barotrauma, Emphysema
- Artificial Intelligence in Healthcare and Education
- Thermoregulation and physiological responses
- Injury Epidemiology and Prevention
- Restraint-Related Deaths
- Hip and Femur Fractures
- Acute Kidney Injury Research
- Infant Nutrition and Health
- Cardiac Health and Mental Health
- Nosocomial Infections in ICU
Clinical Evaluation Research Unit
2019-2023
Ottawa Hospital
2022-2023
Ottawa Hospital Research Institute
2022-2023
Queen's University
2019-2023
Kingston General Hospital
2019-2023
University of Ottawa
2023
Université Laval
2020-2022
Kingston Health Sciences Centre
2020-2022
Mercy Hospital
2021
Florida International University
2021
Abstract Sequence-specific nucleases such as TALEN and the CRISPR/Cas9 system have so far been used to disrupt, correct or insert transgenes at precise locations in mammalian genomes. We demonstrate efficient ‘knock-in’ targeted replacement of multi-kilobase genes human induced pluripotent stem cells (iPSC). Using a model replacing endogenous with their mouse counterpart, we performed comprehensive study targeting vector design parameters for homologous recombination. A 2.7 kilobase (kb)...
OBJECTIVES: To determine the incidence of enteral feed intolerance, identify factors associated with and assess relationship between intolerance key nutritional clinical outcomes in critically ill patients. DESIGN: Analysis International Nutrition Survey database collected prospectively from 2007 to 2014. SETTING: Seven-hundred eighty-five ICUs around world. PATIENTS: Mechanically ventilated adults ICU stay greater than or equal 72 hours received nutrition during first 12 days....
Wolbachia bacteria are intracellular present in the microbiome of a large fraction insects and parasitic nematodes. They can block mosquitos’ ability to transmit several infectious disease-causing pathogens, including Zika, dengue, chikungunya, West Nile viruses malaria parasites. Certain extracellular gut lumen these also pathogen transmission. However, our understanding interactions between how they influence each other is limited. Here we show that presence strain w Mel changes...
Glutamine is thought to have beneficial effects on the metabolic and stress response severe injury. Clinical trials involving patients with burns other critically ill shown conflicting results regarding benefits risks of glutamine supplementation.
Abstract Introduction Real-world evidence on the timing and efficacy of enteral nutrition (EN) practices in intensive care unit (ICU) patients with circulatory shock is limited. We hypothesized early EN (EEN), as compared to delayed (DEN), associated improved clinical outcomes mechanically ventilated (MV) shock. Methods analyzed a dataset from an international, multicenter, pragmatic randomized trial (RCT) evaluating protein dose ICU patients. Data were collected admission, EEN was defined...
Abstract Background Based on low-quality evidence, current nutrition guidelines recommend the delivery of high-dose protein in critically ill patients. The EFFORT Protein trial showed that higher dose is not associated with improved outcomes, whereas effects patients who developed acute kidney injury (AKI) need further evaluation. overall aim to evaluate different stages AKI. Methods In this post hoc analysis trial, we investigated effect high versus usual (≥ 2.2 vs. ≤ 1.2 g/kg body...
Background: An enterocutaneous fistula (ECF) is an aberrant connection between the gastrointestinal tract and skin or atmosphere (enteroatmospheric [EAF]). Multimodal treatment includes surgical procedures, nutrition support, wound care. We evaluated our practice compared outcomes with previous results published from institution. Materials Methods : performed a retrospective analysis of hospitalized ECF/EAF patients admitted January 2011 November 2015. Patients internal fistulas; active...
OBJECTIVES: Across guidelines, protein dosing for critically ill patients with obesity varies considerably. The objective of this analysis was to evaluate whether population would benefit from higher doses protein. DESIGN: A post hoc subgroup the effect in high nutritional risk (EFFORT Protein): an international, multicenter, pragmatic, registry-based randomized trial. SETTING: Eighty-five adult ICUs across 16 countries. PATIENTS: Patients defined as a body mass index (BMI) greater than or...
The Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol (PEP uP) has been shown to be feasible, safe, and effective in delivering significantly more energy/protein, though it not well studied surgical/trauma patients. We hypothesized that PEP uP will effectively increase energy/protein delivery critically ill patients.This multicenter, prospective, randomized pilot study included adult patients admitted surgical service who were expected require mechanical ventilation...
Background:The contribution of stress to obesity-related cardiovascular disease is uncertain. The purpose this study was examine the influence body composition on stress-induced pressure natriuresis.
Neutrophil-lymphocyte ratio (NLR) is a measure of host inflammatory response; higher NLR associated with worse clinical outcomes. Enteral nutrition (EN) may mitigate inflammation through interaction gut-associated lymphoid tissue. We hypothesized that early EN adequacy in critically ill surgical patients lower and better outcomes.In this retrospective study, we analyzed data from adult intensive care unit (ICU) receiving EN. at baseline ICU admission (NLR-B), after 3-5 days (F-NLR),...