A5050166621- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Immune cells in cancer
- Immune Response and Inflammation
- Redox biology and oxidative stress
- Glutathione Transferases and Polymorphisms
Northeast Normal University
2021-2024
Inducible regulatory T (iTreg) cells play a crucial role in immune suppression and are important for the maintenance of homeostasis. Mounting evidence has demonstrated connections between iTreg differentiation metabolic reprogramming, especially rewiring fatty acid oxidation (FAO). Previous work showed that butyrate, specific type short-chain (SCFA) readily produced from fiber-rich diets through microbial fermentation, was critical intestinal homeostasis capable promoting generation by...
Ferroptosis is inhibited by glutathione peroxidase 4 (GPX4), an antioxidant enzyme that uses reduced (GSH) as a cofactor to detoxify lipid hydroperoxides. As selenoprotein, the core function of GPX4 thiol-dependent redox reaction. In addition GSH, other small molecules such cysteine and homocysteine also contain thiols; yet, whether can exploit directly hydroperoxides inhibit ferroptosis has not been addressed. this study, we found in GPX4-dependent manner. However, inhibits independent GSH...
Ferroptosis is a cell death modality in which iron-dependent lipid peroxides accumulate on membranes. Cysteine, limiting substrate for the glutathione system that neutralizes peroxidation and prevents ferroptosis, can be converted by cystine reduction or synthesized from methionine. However, accumulating evidence shows methionine-based cysteine synthesis fails to effectively rescue intracellular levels upon deprivation unable inhibit ferroptosis. Here, we report tissue-specific....
Inducible regulatory T (iTreg) cells play a central role in immune suppression. As iTreg are differentiated from activated (Th0) cells, cell metabolism undergoes dramatic changes, including shift fatty acid synthesis (FAS) to oxidation (FAO). Although the reprogramming is critical, mechanism regulating this process during differentiation still unclear. Here we have revealed that enzymatic activity of ATP-citrate lyase (ACLY) declined significantly upon transforming growth factor β1 (TGFβ1)...