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Jia Liu

ORCID: 0000-0002-9816-7110
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About
Contact & Profiles
A5102768188
Research Areas
  • Cancer, Hypoxia, and Metabolism
  • Glycosylation and Glycoproteins Research
  • Epigenetics and DNA Methylation
  • Ubiquitin and proteasome pathways
  • Metabolism, Diabetes, and Cancer

Northeast Normal University
 2024

 PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer
OPENALEX - Publications 
Yang Wang Hengyao Shu Yanzhao Qu Xin Jin Jia Liu and 14 more Wanting Peng Lihua Wang Miao Hao Mingjie Xia Zhexuan Zhao Kejian Dong Di Yao Miaomiao Tian Fengqi Hao Chaoyi Xia Wenxia Zhang Xueqing Ba Yunpeng Feng Min Wei

10.1038/s44318-024-00110-8 article EN cc-by The EMBO Journal 2024-05-15
 O -GlcNAcylation of ATP-citrate lyase couples glucose supply to lipogenesis for rapid tumor cell proliferation
OPENALEX - Publications 
Jia Liu Yang Wang Miaomiao Tian Mingjie Xia Yi Zheng and 13 more Miao Hao Yuqiang Qian Hengyao Shu Wenxia Zhang Pinghui Peng Zhexuan Zhao Kejian Dong Wanting Peng Tian Gao Zhanjun Li Xin Jin Min Wei Yunpeng Feng

Elevated lipid synthesis is one of the best-characterized metabolic alterations in cancer and crucial for membrane expansion. As a key rate-limiting enzyme de novo fatty acid synthesis, ATP-citrate lyase (ACLY) frequently up-regulated tumors regulated by posttranslational modifications (PTMs). Despite emerging evidence showing O -GlcNAcylation on ACLY, its biological function still remains unknown. Here, we observed significant upregulation ACLY various types human tumor cells tissues...

10.1073/pnas.2402674121 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2024-10-10
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