A5051242276- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Bone health and treatments
- Bone Metabolism and Diseases
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Hepatitis C virus research
- Chronic Lymphocytic Leukemia Research
- NF-κB Signaling Pathways
- Protist diversity and phylogeny
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Inflammatory mediators and NSAID effects
- Plant nutrient uptake and metabolism
- Glycosylation and Glycoproteins Research
- Light effects on plants
- Cytomegalovirus and herpesvirus research
- Cancer Treatment and Pharmacology
- Protein Degradation and Inhibitors
- Plant Gene Expression Analysis
- Cytokine Signaling Pathways and Interactions
- Hematological disorders and diagnostics
The First Affiliated Hospital, Sun Yat-sen University
2012-2025
Sun Yat-sen University
2013-2025
Ludwig-Maximilians-Universität München
2015-2024
Third Affiliated Hospital of Sun Yat-sen University
2016
Dalian Medical University
2016
Lanzhou University
2014
University of Alabama at Birmingham
2004-2010
Interleukin-4 (IL-4) is an important immune regulatory protein that possesses potent anti-osteoclastogenic properties, and does so via the transcription factor STAT6. Previous studies have shown IL-4 selectively blocks RANKL-induced activation of NF-κB mitogen-activated kinase (MAPK) pathway molecules, suggesting cytokine arrests osteoclastogenesis by blockade these signaling cascades. However, fact inhibitory effect on pathways requires prolonged pretreatment, fails to exert after...
Plastid-to-nucleus retrograde signaling plays an important role in regulating the expression of photosynthesis-associated nuclear genes (PhANGs) accordance with physiological demands on chloroplast biogenesis and function. Despite its fundamental importance, little is known about molecular nature plastid gene (PGE)-dependent type signaling. PGE a multifaceted process, several factors, including pentatricopeptide repeat (PPR) proteins, are involved regulation. The PPR protein GUN1 central...
Chloroplast biogenesis is indispensable for proper plant development and environmental acclimation. In a screen mutants affected in photosynthesis, we identified the protein phosphatase7-like (pp7l) mutant, which displayed delayed chloroplast cotyledons young leaves. PP7L, PP7, PP7-long constitute subfamily of phosphoprotein phosphatases. PP7 thought to transduce blue-light signal perceived by crys phy that induces expression SIGMA FACTOR5 (SIG5). We observed that, like PP7L was...
Plastid gene expression is crucial for plant development and acclimation to various environmental stress conditions. Members of the so-called "mitochondrial transcription termination factor" (mTERF) family, which are present in both metazoans plants, involved organellar expression. Arabidopsis thaliana contains 35 mTERF proteins, mTERF10, mTERF11 mTERF12 were previously assigned "chloroplast-associated" group. Here, we show that all three localized chloroplast nucleoids, associated with...
Summary Lincomycin (LIN)‐mediated inhibition of protein synthesis in chloroplasts prevents the greening seedlings, represses activity photosynthesis‐related genes nucleus, including LHCB1.2 , and induces phenylpropanoid pathway, resulting production anthocyanins. In genomes uncoupled ( gun ) mutants, expression is maintained presence LIN or other inhibitors early chloroplast development. a screen using concentrations lower than those employed to isolate we have identified happy on lincomycin...
Haploidentical donor (HID) allogeneic hematopoietic stem cell transplantation (HSCT) is an alternative curative treatment for patients with severe aplastic anemia (SAA) who do not have suitable matched related donors (MRD). The aim of this study was to compare the therapeutic outcomes HID-HSCT those MRD-HSCT SAA.A total 235 SAA underwent (116) or (119) at 11 centers from January 2007 2016 were included. Complications and survival evaluated compared between 2 groups.The HID group had a lower...
Plastid biogenesis and the coordination of plastid nuclear genome expression through anterograde retrograde signaling are essential for plant development. GENOMES UNCOUPLED1 (GUN1) plays a central role in during early The putative function GUN1 has been extensively studied, but its molecular remains controversial. Here, we evaluate published transcriptome data generate our own from gun1 mutants grown under signaling-relevant conditions to show that editing splicing not relevant...
Receptor activator of NF-kappa B ligand (RANKL) and its receptor (RANK) play pivotal roles in osteoclast differentiation function. However, the structural determinants RANK that mediate formation function have not been definitively identified. To address this issue, we developed a chimeric approach permits structure/function study cytoplasmic domain osteoclasts. Using approach, examined role six putative tumor necrosis factor receptor-associated factor-binding motifs (PTM) (PTM1,...
Receptor activator of NF-kappaB (RANK) ligand (RANKL) and its receptor RANK play an essential role in osteoclastogenesis osteoclast function by activating several signaling pathways. However, lines evidence suggest that also transmits unidentified pathway(s) for osteoclastogenesis. To identify the novel pathway(s), we carried out a detailed structure/function study cytoplasmic domain. A series studies using numerous deletion/point mutants elucidated specific 4-amino acid motif (535IVVY538)...
Although interferon-γ (IFN-γ) potently inhibits osteoclastogenesis, the suppressive effect is significantly reduced when osteoclast precursors are pre-exposed to receptor activator of NF-κB (RANK) ligand (RANKL). However, molecular mechanism underlying biphasic effects IFN-γ on osteoclastogenesis remains elusive. Here, we recapitulate functions in both tissue culture dishes and bone slices. We further demonstrate that markedly suppresses RANKL-induced expression nuclear factor activated...
RNA-directed DNA methylation (RdDM) helps to defend plants against invasive nucleic acids. In the canonical form of RdDM, 24-nt small interfering RNAs (siRNAs) are produced by DICER-LIKE 3 (DCL3). The siRNAs loaded onto ARGONAUTE (AGO) proteins leading ultimately de novo methylation. Here, we introduce Arabidopsis thaliana prors1 (LUC) transgenic system, in which generated silence promoter-LUC construct. A forward genetic screen performed with this system identified, besides known components...
We conducted a phase II, noncomparative, multicenter study to assess the efficacy and safety of allogeneic bone marrow-derived mesenchymal stromal cells (BM-MSCs) expanded in vitro for patients with aplastic anemia (AA) refractory immunosuppressive therapy. Seventy-four from seven centers received BM-MSCs at dose 1-2 × 106 cells/kg per week 4 weeks. Responses were assessed 0.5, 1, 2, 3, 6, 9, 12 months after first infusion. Patients response 1 month continued receive four infusions. All...
Chloroplast biogenesis depends on an extensive interplay between the nucleus, cytosol, and chloroplasts, involving regulatory nucleus-encoded chloroplast proteins, as well nucleocytosolic photoreceptors such phytochromes (phys) other extrachloroplastic factors. However, this whole process is only partially understood. Here, we describe role of VENOSA4 (VEN4) in development acclimation to adverse growth conditions. A 35S:VEN4-eGFP fusion protein localizes nucleus Arabidopsis (Arabidopsis...
Plants have evolved sophisticated mechanisms to cope with drought, which involve massive changes in nuclear gene expression. However, little is known about the roles of post-transcriptional processing or organellar transcripts and how meaningful these are. To address issues, we used RNA-sequencing after ribosomal RNA depletion monitor (post)transcriptional during different times drought exposure Arabidopsis Col-0. Concerning detected transcriptomes, chloroplast transcript levels were...
China has witnessed a remarkable increase in sexually transmitted infections (STIs) and HIV. The study is to assess the prevalence of HIV, HBV, HCV syphilis related risk factors among drug users mandatory detoxification center Qingyuan, Guangdong, China.A cross-sectional on use behaviors, sex presence antibodies HCV, Treponema pallidum, surface antigen HBV (HBsAg) was conducted recruited from 3 centers China. Risk for each four were analyzed with logistic regression model.A total 740...
Abstract Plastid biogenesis and the coordination of plastid nuclear genome expression through anterograde retrograde signaling are essential for plant development. GENOMES UNCOUPLED1 (GUN1) plays a central role in during early The putative function GUN1 has been extensively studied, but its molecular remains controversial. Here, we evaluate published transcriptome data generate our own from gun1 mutants grown under relevant conditions to show that editing splicing not GUN1-dependent...
The application of haploidentical hematopoietic stem cell transplantation (HSCT) with mesenchymal (MSC) infusion as a treatment regimen for severe aplastic anemia (SAA) has been reported to be efficacious in single-arm trials. However, it is difficult assess without comparing the results those from first-line, matched-sibling HSCT. Herein, we retrospectively reviewed 91 patients acquired SAA. They received HSCT donors combined MSC transfer (HID group). We compared these 103 others who...
Abstract Objectives To analyze psychological states and needs of patients after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Methods Questionnaires were sent to 101 allo‐HSCT survivors 96 questionnaires returned. The questionnaire covered several categories: (1) demographics general information, (2) physical conditions, (3) psychologic status sleep quality, (4) survivor's comments on transplantation, (5) demands needs, (6) preferred forms channels information. Results...
To investigate the timing, safety and efficacy of prophylactic antiviral therapy in patients with hepatitis B virus (HBV) infection undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).This prospective study recruited a total 57 diagnosed malignant hematological diseases HBV at First Affiliated Hospital Sun Yat-sen University between 2006 2013. The were classified as surface antigen (HBsAg)-positive or HBsAg-negative/ antiHBc-positive. Patients treated chemotherapy...
The purposes of this study were to evaluate the infection by hepatitis B virus (HBV) and its impact on survival provide a clinical reference for monitoring treating HBV during after autologous hematopoietic stem cell transplantation (ASCT) in patients with multiple myeloma (MM). A retrospective analysis infections was performed 70 MM who received sequential bortezomib-containing induction therapy ASCT our department from June 2006 February 2012. Among study, 11 cases (15.7 %) surface antigen...
Recently, certain studies have demonstrated in vitro that prostaglandin E2 (PGE2) promotes human cluster of differentiation (CD)34+ cell homing. However, the sub‑type receptors activated by PGE2 are unknown, as receptor EP1-4 subtypes (EP1-4) expressed on membrane CD34+ cells. Based above, present study aimed to screen subtype activity promote It was observed cells four sub‑receptors, particularly EP2 and 4. increased 4 mRNA expression significantly, while EP1 3 exhibited no significant...