A5033585083- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Circular RNAs in diseases
- Reproductive Physiology in Livestock
- Cytokine Signaling Pathways and Interactions
Institute of Animal Reproduction and Food Research
2014-2022
Polish Academy of Sciences
2014-2022
Embryo implantation is a complex, synchronized process that requires establishment of reciprocal dialogue between receptive endometrium and developing blastocysts. Recently, microRNAs (miRNAs), known to modulate gene expression through post-transcriptional mechanisms, were implicated in regulation early pregnancy events including maternal recognition implantation. To characterize complex transcriptomic changes, miRNAs pregnant cyclic endometria collected on days 12, 16 20 was analyzed using...
In early pregnancy, as the embryo arrives in uterus, intensive communication between and uterus begins. Hundreds of molecules are known to be involved, but despite numerous findings, full understanding complexity embryo–maternal dialog remains elusive. Recently, extracellular vesicles, nanoparticles able transfer functionally active cargo cells, have emerged important players cell–cell communication, such, they gained great attention over past decade also reproductive biology. Here, we use a...
Circulating miRNAs were proposed to be indicators of normal or complicated pregnancies. Based on this knowledge and our recent transcriptomic approach showing expression in the porcine endometrium, conceptuses uterine extracellular vesicles during pregnancy, we have hypothesized that signs ongoing local embryo-maternal crosstalk involving can detected circulation pregnant gilts as early a few days after maternal recognition pregnancy. By applying several molecular biology techniques differ...
Circulating, non-coding RNAs, such as microRNAs (miRNAs) have been proposed to be powerful pathophysiological indicators of pregnancy in animals and humans. Since their discovery, it is known that miRNAs can take part numerous biological processes, including cell proliferation differentiation during early embryonic development establishment pregnancy. Our recent studies indicated maternal blood carry reported previously at the embryo–maternal interface pigs. To expand scope our research, we...
Abstract In early pregnancy, as the embryo arrives in uterus, intensive communication between and uterus begins. Hundreds of molecules are known to be involved, but despite numerous findings, full understanding complexity embryo–maternal dialog remains elusive. Recently, extracellular vesicles, nanoparticles able transfer functionally active cargo cells, have emerged important players cell–cell communication, such, they gained great attention over past decade also reproductive biology. Here...