A5061592347- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- RNA regulation and disease
- SARS-CoV-2 and COVID-19 Research
Yangzhou University
2023-2025
Jiangsu Academy of Agricultural Sciences
2023-2025
Ministry of Science ICT and Future Planning
2024-2025
Ministère de l'Agriculture et de la Souveraineté alimentaire
2024-2025
Swine coronavirus-porcine epidemic diarrhea virus (PEDV) with specific susceptibility to pigs has existed for decades, and recurrent epidemics caused by mutant strains have swept the world again since 2010. In this study, single-cell RNA sequencing was used perform first time, our knowledge, a systematic analysis of pig jejunum infected PEDV. Pig intestinal cell types were identified representative markers new tuft marker, DNAH11. Excepting enterocyte cells, goblet cells confirmed Enrichment...
ABSTRACT Variant Porcine epidemic diarrhea virus (PEDV), which causes and high mortality in piglets, has become a major pathogen, co-epidemics of different subtypes the have very thorny problem for clinical prevention control PEDV. However, cross-protection between G2a G2b subtype strains not been observed, there is currently no vaccine against both strains. In this study, we demonstrate low with piglet immunization challenge tests. The trimeric full-length S proteins variants were purified...
In recent years, porcine diarrhea-associated viruses have caused significant economic losses globally. These present similar clinical symptoms, such as watery diarrhea, dehydration, and vomiting. Co-infections with epidemic diarrhea virus (PEDV) transmissible gastroenteritis (TGEV) are common. For the rapid on-site preliminary diagnosis on pig farms, this study aimed to develop a colloidal gold immunochromatography assay (GICA) strip for detection of PEDV TGEV simultaneously. The GICA kit...
Porcine epidemic diarrhea (PED) is a highly contagious swine intestinal disease caused by PED virus (PEDV). Vaccination promising strategy to prevent and control PED. Previous studies have confirmed that glycosylation could regulate the immunogenicity of viral antigens. In this study, we constructed three recombinant PEDVs which removed sites in RBD. Viral infection assays revealed similar replication characteristics between viruses parental PEDV. Although animal challenging study...
ABSTRACT Coronaviruses have undergone evolutionary changes and mutations in response to the immune pressures exerted by vaccines environmental factors, resulting more severe consequences during breakthrough infections. Nevertheless, specific correlation between of coronaviruses remains ambiguous. Swine coronavirus—porcine epidemic diarrhea virus (PEDV)—has existed for decades. This study utilized vivo preparation polyclonal antibodies against PEDV identified critical neutralizing epitopes...
Abstract The precise role of the highly variable coronavirus S protein in modulating innate immune responses remains unclear. In this study, we demonstrated that mutant strain swine porcine enteric diarrhea virus induced significantly lower levels double-stranded RNA (dsRNA) accumulation, inhibited kinase R (PKR) activation and suppressed stress granule (SG) formation compared with classical strain. 29th amino acid at N-terminus was identified as key functional site for regulation SG...