A5103113992- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Chemokine receptors and signaling
- Inflammatory mediators and NSAID effects
- Protease and Inhibitor Mechanisms
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Total Knee Arthroplasty Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Veterinary Equine Medical Research
- Smart Grid Security and Resilience
- Hip disorders and treatments
- Polyoxometalates: Synthesis and Applications
- Bone and Joint Diseases
- Nanocluster Synthesis and Applications
- Software-Defined Networks and 5G
- Musculoskeletal synovial abnormalities and treatments
- Neuropeptides and Animal Physiology
- Synthesis of β-Lactam Compounds
- Effects of Radiation Exposure
- Knee injuries and reconstruction techniques
First Affiliated Hospital of Kunming Medical University
2017-2025
Kunming Medical University
2017-2025
Cangzhou Central Hospital
2025
Jilin Electric Power Research Institute (China)
2024
Boston Children's Hospital
2013-2015
Harvard University
2013-2015
Boston University
2013
Osteoarthritis (OA) is one of the most common diseases affecting older people; however, there remains no effective targeted drug to combat OA. The aims this study were (1) explore effect T140 in regulating degeneration articular cartilage vivo by blocking SDF-1/CXCR4 signaling pathway, and (2) provide experimental evidence for development a novel OA-targeted pharmacotherapy. Thirty-six healthy Hartley guinea pigs randomly divided into three groups: T140-treated group (n = 12), phosphate...
The "Anchang" Group Prescription (ACZF), based on the traditional Bai Tou Weng Decoction and Si Jun Zi Decoction, has demonstrated clinical efficacy in alleviating symptoms of radiation enteritis (RE). Nevertheless, precise active components their underlying molecular mechanisms ACZF's effect RE require further elucidation. This investigation seeks to delineate explore by which ACZF mitigates RE, utilizing both network pharmacology experimental approaches provide a solid theoretical base for...
Osteoarthritis (OA) is a chronic joint function disorder with characteristics of chondrocytes reduction and extracellular matrix (ECM) components destruction. MicroRNAs (miRNAs) the SDF-1/CXCR4 axis are essential factors chondrocyte apoptosis ECM degeneration. However, very few studies have investigated correlation between miRNAs in osteoarthritis so far. Here, through microarray bioinformatics analyses, we identified miR-142-5p as CXCR4-targeted dramatically downregulated miRNA cartilage...
Osteoarthritis (OA) is an aseptic inflammatory disease which associated with the stromal cell‑derived factor 1/C‑X‑C chemokine receptor type 4 (SDF‑1/CXCR4) axis. Accumulating studies have identified numbers of microRNAs (miRNAs) that serve important roles in pathogenesis OA. However, whether and how inhibition SDF‑1/CXCR4 axis induces alterations miRNA expression remains largely unclear. profiling was performed OA chondrocytes stimulated SDF‑1 alone, or CXCR4 antagonist TN14003 by...
We have previously identified a zinc finger transcription factor, ZNF24 (zinc protein 24), as novel inhibitor of tumor angiogenesis and demonstrated that exerts this effect by repressing the VEGF in breast cancer cells. Here we focused on role modulating angiogenic potential endothelial compartment. Knockdown siRNA human primary microvascular cells (ECs) led to significantly decreased cell migration invasion compared with control siRNA. knockdown consistently impaired receptor 2 (VEGFR2)...
Ferroptosis and dysregulation of long non-coding RNA (lncRNA) have been described to be strictly relevant the pathogenesis osteoarthritis (OA). However, connection between ferroptosis lncRNA in OA is poorly appreciated. Herein, we investigated functional contribution markers correlated with progression human by comprehensive bioinformatics analysis a panoramic network competing endogenous (ceRNA) based on ferroptosis-related genes (FRGs).FRGs-related networks were generated using...
Abstract Background Varieties of animals were used to study osteoarthritis pathogenesis. The Diannan small-ear pig, which is native Yunnan, China, thought have an articular anatomy similar that humans and more likely be a source pathological tissues than other animals. aim this was determine whether animal can serve as effective model explore the role SDF-1/CXCR4 signaling pathway in development Osteoarthritis Methods Twenty-seven adult pigs randomly divided into three groups underwent Hulth...
Abstract Background This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) at microRNA target sequence in CXCR4 and susceptibility knee osteoarthritis (KOA). Methods A total of 305 patients with KOA healthy controls were recruited into this study. The genotypes rs1804029 rs17848060 loci analyzed. Results G allele carriers was 1.33 times (95% CI: 1.09‐1.54, P = .006) that T carriers. individuals carrying locus 1.38 1.17‐1.57, < .001)....
Objective To investigate the short-term effectiveness of total knee arthroplasty (TKA) assisted by three-dimensional (3D) printing osteotomy navigation template. Methods A retrospective study was performed on 60 patients with osteoarthritis bewteen January 2016 and June 2017. Thirty cases underwent TKA 3D template (3D group) 30 conventional (conventional group). There no significant difference in gender, age, body mass index, surgical side, disease duration between 2 groups ( P>0.05). The...
Tendon cysts of the iliopsoas muscle cause pain and snapping hip. These are close to femoral nerve blood vessels, risk open surgery is high, with cyst recurrence occurring frequently. We describe a method hip arthroscopy for orderly excision cysts. During operation, tendon identified released, excised, peritendinous osteophytes formed successively. This technique minimally invasive, safe, highly effective that addresses both intra- extra-articular lesions.
Gene regulatory network analysis has found that long noncoding ribonucleic acids (lncRNAs) are strongly associated with the pathogenesis of osteoarthritis.
To investigate the effectiveness of posterior-posterior triangulation technique for arthroscopic posterior cruciate ligament (PCL) reconstruction by comparing with anteroposterior approach.Retrospective analysis was performed on 40 patients who underwent PCL between February 2016 and 2020. The PCLs were reconstructed via approach in 20 (anteroposterior group) (posterior-posterior group). There no significant difference gender, age, cause injury, injury side, disease duration, preoperative...
Abstract Angiogenesis, the formation of new blood vessels from preexisting ones, is an indispensible process under normal physiological conditions such as embryonic development, certain stages female reproductive cycle and placenta during pregnancy well pathological wound healing, diabetic retinopathy, cancer initiation, progression metastasis. We have previously identified molecular mechanism by which a zinc finger transcription factor, ZNF24, functions inhibitor tumor angiogenesis. ZNF24...
Abstract Background : Previous study have revealed that miR-146a-5p has a role in osteoarthritis (OA) development, here, we aim to further explore the underlying mechanism of miR-146a-5P OA both vitro and . Methods RT-PCR was used detect level patients. Primary chondrocytes were treated with SDF-1 induce an model , IL-1β mediated rats also used. Gain- or loss- function assays TRAF6 conducted determine their roles regulating proliferation, apoptosis cartilage degradation chondrocytes. Results...