A5006841449- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Social and Intergroup Psychology
- Neural dynamics and brain function
- Evolutionary Psychology and Human Behavior
- Psychology of Moral and Emotional Judgment
- Face Recognition and Perception
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Cultural Differences and Values
- Alzheimer's disease research and treatments
- Decision-Making and Behavioral Economics
- Advanced MRI Techniques and Applications
- Memory Processes and Influences
- Language, Metaphor, and Cognition
- Categorization, perception, and language
- Behavioral Health and Interventions
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Human-Animal Interaction Studies
- Mitochondrial Function and Pathology
- Elder Abuse and Neglect
- Metabolism and Genetic Disorders
- Multisensory perception and integration
Indiana University Bloomington
2017-2024
Montreal Neurological Institute and Hospital
2021-2024
McGill University
2021-2024
University of Maryland, Baltimore
2006
University of Illinois Urbana-Champaign
1991
University of Illinois Chicago
1989-1991
Abstract The intrinsic functional organization of the brain changes into older adulthood. Age differences are observed at multiple spatial scales, from global reductions in modularity and segregation distributed systems, to network-specific patterns dedifferentiation. Whether dedifferentiation reflects an inevitable, shift function with age, circumscribed, experience-dependent changes, or both, is uncertain. We employed a multimethod strategy interrogate scales. Multi-echo (ME) resting-state...
Abstract The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are earliest sites of tauopathy in Alzheimer’s disease (AD). They project broadly throughout brain’s white matter. We investigated relationship between IdC microstructure and whole-brain matter to better understand early neuropathological changes AD. Using multiparametric quantitative magnetic resonance imaging we observed two covariance patterns 133 cognitively unimpaired older adults (age 67.9 ± 5.3 years)...
Functional connectivity – the co-activation of brain regions forms basis brain's functional architecture. Often measured during resting-state (i.e., in a task-free setting), patterns within and between networks change with age. These are interest to aging researchers because age differences relate older adults' relative cognitive declines. Less is known about large-scale directed tasks. Recent work younger adults has shown that highly correlated rest task states. Whether this finding extends...
Elevated iron deposition in the brain has been observed older adult humans and persons with Alzheimer's disease (AD), associated lower cognitive performance. We investigated impact of deposition, its topographical distribution across hippocampal subfields segments (anterior, posterior) measured along longitudinal axis, on episodic memory a sample cognitively unimpaired adults at elevated familial risk for AD ( N = 172, 120 females, 52 males; mean age 68.8 ± 5.4 years). MRI-based quantitative...
This study explores the relationship between results of tests dementia and EEG findings in 94 demented patients different etiologies. Abnormal EEGs were found 83% all patients, usually diffuse slow wave abnormalities, degree which correlated very well with Modified Hachinski test. Only a weak was Mini-Mental Status Examination, while Mattis its subtests better. Focal abnormalities on temporal areas characteristic pattern alcoholic dementia. The test scores 17% normal consistent above...
Mentalizing, or thinking about others' mental states, shapes social interactions. Older adults (OA) have reduced mentalizing capacities reflected by lower medial prefrontal cortex (mPFC) activation. The current study assessed if OA' mPFC activation reflects less spontaneous during person perception. Younger (YA) and OA viewed ingroup White outgroup Black Asian faces completed a task fMRI. Afterward, they in which inferred states from faces. Using an region defined the task, had activity than...
Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias emerges in older adulthood would be associated with lower microstructural integrity coeruleus. Leveraging vivo histological methods from quantitative MRI-magnetic transfer saturation—we provide evidence age is integrity. Critically, we demonstrate bias adulthood, assessed...
This study on 500 prematures and neonates with conceptional ages (CA) of 23-49 wks describes the STOP pattern (sharp theta occipitals prematures). is similar to PT (premature temporal theta) in configuration, but faster frequency, lower amplitude, more often unilateral, aside from obvious difference location. The incidence (%) was highest at youngest age, decreasing zero near term, amount (number bursts) greatest 25 (CA). Three different parts appear amplitude curves, these three may be...
Two experiments investigated the effects of number health recommendations (e.g., quit smoking; relax for a day) contained in health-promotion message on recommendation recall and intentions to enact recommendations. We hypothesized that if are stored individually, higher presented will increase recalled As increases, however, recipients likely summarize more as part single, general theme (or header), resulting decrease proportion ( N = 193 266) found total increased decreased with Experiment...
Abstract The intrinsic functional organization of the brain changes into older adulthood. Age differences are observed at multiple spatial scales, from global reductions in modularity and segregation distributed systems, to network-specific patterns dedifferentiation. Whether dedifferentiation reflects an inevitable, shift function with age, circumscribed, experience dependent changes, or both, is uncertain. We employed a multi-method strategy interrogate scales. Multi-echo (ME)...
Outgroup members (e.g., individuals whose racial identity differs from perceivers') are stigmatized in Eastern and Western cultures. However, it remains an open question how specific cultural influences affect stigmatization. In this study, we assessed whether learning (i.e., social information acquired the people one's environment) associated with Chinese individuals' relocation to United States differentiated response multiple outgroups. Two types of predict diverging responses outgroups -...
Prior work on aging and prejudice has identified that declining executive ability underlies older adults' (OA') increased anti-outgroup bias. The current work, however, suggests there may also be a motivational reason. Here, we explored the possibility for OA with relatively lower ability, bias serve an ironic purpose of maximizing fundamental social goal: maintaining ingroup positivity. are more motivated than young adults (YA) to maximize positivity in everyday life. This process, can...
The goal of this study on 199 premature infants (24-41 weeks CA) was to investigate the electro-clinical correlations positive and negative sharp waves, comparing those from temporal central areas. Positive discharges were seen more often less than 30 CA type greater weeks. Patients without waves rarely have seizures with paroxysms do, dependent in part number these discharges. When are found frontal or occipital areas, where they uncommonly occur, incidence seizure almost doubles, compared...
Abstract The affective polarization characteristic of the United States’ political climate contributes to pervasive intergroup tension. This tension polarizes basic aspects person perception, such as face impressions. For instance, impressions are polarized by partisanship disclosure that people form positive and negative of, respectively, shared opposing partisan faces. How interacts with other facial cues affecting remains unclear. Building on work showing trustworthiness, a core dimension...
Abstract Although stigma is a major barrier to treatment for those with mental health concerns, it poorly understood when more or less influential in decisions. In the current work, we examined whether psychological distance—the removal of an event from direct experience—reduced influence internalized on willingness seek treatment. Specifically, tested hypothesis that distance versus proximity (e.g., seeking three months vs. two days, respectively) decreases negative We focused population...
Older adults (OA) evaluate faces to be more trustworthy than do younger (YA), yet the processes supporting these positive evaluations are unclear. This study identified neural mechanisms spontaneously engaged during face perception that differentially relate OA’ and YA’ later trustworthiness evaluations. We examined two mechanisms: salience (reflected by amygdala activation) reward caudate – both of which implicated in evaluating trustworthiness. emphasized value specific having OA YA...
Americans' increasing levels of ideological polarization contribute to pervasive intergroup tensions based on political partisanship. Cues partisanship may affect even the most basic aspects perception. First impressions faces constitute a widely-studied aspect person perception relating tensions. To understand relation between face and polarization, two experiments were designed test whether disclosing affected perceivers' ideology. Disclosed more strongly people's than actual, undisclosed,...
Older age is associated with poorer ability to accurately infer mental states, but some states are more complex than others. Sarcasm a state because the literal and intended meaning of speaker's words in opposition. Individuals must rely on additional cues (e.g., facial expressions, intonation) for accurate inference. We hypothesized that understanding sarcastic versus sincere exchanges would be sensitive age-related difficulty understanding.
The default network is widely implicated as a common neural substrate for self-generated thought, such remembering one's past (autobiographical memory) and imagining the thoughts feelings of others (theory mind). Findings that comprises subnetworks regions, some commonly distinctly involved across processes, suggest own experiences inform their understanding others. With advent precision functional MRI (fMRI) methods, however, it unclear if this shared observed instead due to traditional...
Motivation: Understanding prodromal Alzheimer’s disease is essential for treatment development. Hippocampal volume loss indicates significant atrophy and may occur too late to slow progression. Goal(s): We aimed precisely map spatial variation in hippocampal microstructure vivo using quantitative MRI AD. Approach: use multiparametric comprehensively healthy older adults with first-degree family history of correlate maps demographic risk factors Alzheimer's disease. Results:...