A5075646734- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Computational Drug Discovery Methods
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Cancer-related Molecular Pathways
- T-cell and B-cell Immunology
- Protein Structure and Dynamics
- CAR-T cell therapy research
- Enzyme Structure and Function
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Biochemical and Molecular Research
- Receptor Mechanisms and Signaling
- Vaccine Coverage and Hesitancy
- Genomics and Chromatin Dynamics
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Cardiac Ischemia and Reperfusion
- Invertebrate Immune Response Mechanisms
NYU Langone Health
1998-2025
New York University
2014-2024
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2023
York University
2020
University School
2010-2018
New York Proton Center
2014-2015
Cornell University
2014
Xiaomi (China)
2011
Arthur M. Sackler Gallery
2009
La Roche College
2005
The COVID-19 pandemic is caused by infection with the SARS-CoV-2 virus. major mutation detected to date in viral envelope spike protein, which responsible for virus attachment host and also main target antibodies, a of an aspartate (D) at position 614 found frequently Chinese strains glycine (G). We sought infer health impact this mutation.Increased case fatality rate correlated strongly proportion viruses bearing G614 on country basis. amino acid occurs internal protein interface spike,...
Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of various malignancies, including colorectal carcinomas, and it is a key therapeutic target combating cancers. Despite significant effort, successful clinical implementation CRT inhibitory therapeutics remains challenging goal. This is, part, because challenge identifying compounds that specifically modulate nuclear transcriptional activity while not affecting its cytoskeletal function stabilizing...
Genetic screens in zebrafish (Danio rerio) have isolated mutations hundreds of genes with essential functions. To facilitate the identification candidate for these mutations, we genetically mapped 104 and expressed sequence tags by scoring single-strand conformational polymorphisms a panel haploid siblings. integrate this map existing genetic maps, also scored 275 previously genes, microsatellites, sequence-tagged sites same panel. Systematic phylogenetic analysis defined likely mammalian...
The Thai Phase III clinical trial (RV144) showed modest efficacy in preventing HIV-1 acquisition. Plasma collected from HIV-1-uninfected participants completing all injections with ALVAC-HIV (vCP1521) prime and AIDSVAX B/E boost were tested for antibody responses against gp120 envelope (Env). Peptide microarray analysis six subtypes group M consensus that vaccination induced to the second variable (V2) loop of multiple subtypes. We further evaluated V2 by ELISA surface plasmon resonance...
In the ubiquitin proteasome system, E3 ligase SCF-Skp2 and its accessory protein, Cks1, promote proliferation largely by inducing degradation of CDK inhibitor p27. Overexpression Skp2 in human cancers correlates with poor prognosis, deregulation SCF-Skp2-Cks1 promotes tumorigenesis animal models. We identified small molecule inhibitors specific to activity using silico screens targeted binding interface for These compounds selectively inhibited Skp2-mediated p27 reducing through key...
The RV144 clinical trial of a prime/boost immunizing regimen using recombinant canary pox (ALVAC-HIV) and two gp120 proteins (AIDSVAX B E) was previously shown to have 31.2% efficacy rate. Plasma specimens from vaccine placebo recipients were used in an extensive set assays identify correlates HIV-1 infection risk. Of six primary variables that studied, only one displayed significant inverse correlation with risk infection: the antibody (Ab) response fusion protein containing V1 V2 regions...
The third variable region (V3) of the HIV-1 surface glycoprotein, gp120, plays a central role in interaction virus envelope with cell chemokine receptors, triggering membrane fusion and entry into human lymphocytes macrophages. CXCR4 CCR5 receptors are used by "X4-tropic" "R5-tropic" viruses, respectively. Recently, crown V3 loop was shown to bear close structural homology β2–β3 CXC CC chemokines, natural ligands CCR5, This can serve as foundation for 3D molecular modeling loops from primary...
Abstract Many of the gene mutations found in genetic disorders, including cancer, result premature termination codons (PTC) and rapid degradation their mRNAs by nonsense-mediated RNA decay (NMD). We used virtual library screening, targeting a pocket SMG7 protein, key component NMD mechanism, to identify compounds that disrupt SMG7–UPF1 complex inhibit NMD. Several these upregulated NMD-targeted at nanomolar concentrations, with minimal toxicity cell-based assays. As expected, pharmacologic...
Genome sequencing studies have revealed a number of cancer-associated mutations in the telomere-binding factor POT1. Here, we show that when combined with p53 deficiency, depletion murine POT1a common lymphoid progenitor cells fosters genetic instability, accelerates onset, and increases severity T cell lymphomas. In parallel, examined human mouse carrying POT1 found cutaneous lymphoma (CTCL) patients. Inhibition activates ATR-dependent DNA damage signaling induces telomere fragility,...
Abstract The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by limiting the availability of initiator methionyl-tRNA for translation. Such conditions paradoxically stimulate translation ATF4 mRNA through a regulatory 5′ leader sequence with multiple upstream Open Reading Frames (uORFs), thereby activating stress-responsive gene expression. Here, we report identification two critical regulators such induction, noncanonical initiation factors eIF2D and DENR ....
Abstract Five models have been built by the ICM method for Comparative Modeling section of Meeting on Critical Assessment Techniques Protein Structure Prediction. The targets homologous proteins with known three‐dimensional structure sequence identity ranging from 25 to 77%. After alignment target related structure, modeling procedure consists two subproblems: side‐chain prediction and loop prediction. approaches these problems following steps: (1) a starting model is created based conserved...
Pathogenicity islands are chromosomal gene clusters, often located adjacent to tRNA genes, that encode virulence factors present in pathogenic organisms but absent or sporadically found related non‐pathogenic species. The selC locus is the site of integration different pathogenicity uropathogenic Escherichia coli , enterohaemorrhagic E. and Salmonella enterica . We show here Shigella flexneri aetiological agent bacterial dysentery, also contains a island. This island, designated SHI‐2 ( Sh...
Genetic screens in zebrafish ( Danio rerio ) have isolated mutations hundreds of genes essential for vertebrate development, physiology, and behavior. We constructed a genetic linkage map that will facilitate the identification candidate these allow comparisons among genomes other vertebrates. On this map, we localized 771 expressed sequence tags (ESTs) by scoring single-stranded conformational polymorphisms (SSCPs) meiotic mapping panel. Of sequences, 642 represent previously unmapped ESTs....
An actomyosin motor located underneath the plasma membrane drives motility and host-cell invasion of apicomplexan parasites such as Plasmodium falciparum vivax, causative agents malaria. Aldolase connects actin filaments to transmembrane adhesive proteins thrombospondin-related anonymous protein (TRAP) family transduces force across parasite surface. The TRAP-aldolase interaction is a distinctive critical trait host hepatocyte by sporozoites, with likely similar crucial for erythrocyte...
In many human cancers, the tumor suppressor, p27(kip1) (p27), a cyclin-dependent kinase inhibitor critical to cell cycle arrest, undergoes perpetual ubiquitin-mediated proteasomal degradation by E3 ligase complex SCF-Skp2/Cks1 and/or cytoplasmic mislocalization. Lack of nuclear p27 causes aberrant progression, and mediates migration/metastasis. We previously showed that mitogenic 17-β-estradiol (E2) induces Skp1-Cullin1-F-Box- S phase kinase-associated protein2/cyclin dependent regulatory...