A5073223978- Erythrocyte Function and Pathophysiology
- Natural product bioactivities and synthesis
- Drug Transport and Resistance Mechanisms
- Lipid Membrane Structure and Behavior
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- DNA Repair Mechanisms
- Tuberculosis Research and Epidemiology
- Free Radicals and Antioxidants
- Mycobacterium research and diagnosis
- Advanced biosensing and bioanalysis techniques
- NF-κB Signaling Pathways
- HIV/AIDS drug development and treatment
- Psoriasis: Treatment and Pathogenesis
- Biomedical Research and Pathophysiology
- Neonatal Health and Biochemistry
- Cholesterol and Lipid Metabolism
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Steroid Chemistry and Biochemistry
- Phytochemistry and Biological Activities
- DNA and Nucleic Acid Chemistry
- Chemokine receptors and signaling
- Single-cell and spatial transcriptomics
- Estrogen and related hormone effects
Poznan University of Medical Sciences
2011-2021
ESPCI Paris
2020-2021
Laboratory Colloïdes et Matériaux Divisés
2020-2021
Centre National de la Recherche Scientifique
2013-2021
Institut Pasteur
2011-2019
Université Paris Cité
2013
Korea University Medical Center
2012
Vall d'Hebron Institut de Recerca
2012
Vall d'Hebron Institute of Oncology
2012
Nagahama Institute of Bio-Science and Technology
2005
Approximately 1 of every 250 newborns has some abnormality genital and/or gonadal development. However, a specific molecular cause is identified in only 20% these cases disorder sex development (DSD). We family French origin presenting with 46,XY DSD and congenital heart disease. Sequencing the ORF GATA4 heterozygous missense mutation (p.Gly221Arg) conserved N-terminal zinc finger GATA4. This was not observed 450 ancestry-matched control individuals. The compromised ability protein to bind...
Passiflora caerulea L., P. alata Curtis and incarnata L. (synonym for edulis Sims), are the most popular representatives of genus in South America. In recent years, a growing attention is paid to biological activity phytochemical profiles crude extracts from various species worldwide. The aim this study was evaluate compare anti-leukemic dry leaves three greenhouse Poland two human acute lymphoblastic leukemia cell lines: CCRF-CEM its multidrug resistant variant. Two systems liquid...
Recent genome-wide association studies have revealed numerous genetic associations between specific single-nucleotide polymorphisms (SNPs) and immune-mediated inflammatory diseases. The current challenge is to identify of the variants with effector mechanisms implicated in pathogenesis. This study was undertaken investigate link variation at loci associated spondyloarthritis (SpA) function CD4+ T lymphocyte subsets involved chronic disease.Expression Th17 Th1 cytokines transcription factors...
So far, a protective influence of phytosterols on the human organism and atherogenesis has been suggested. Most studies have concentrated cytotoxic efficacy cancer cells. However, there are only few reports showing their normal The aim present study was to determine whether dietary plant sterols thermal processing products could viability normal, abdominal endothelial cells that play crucial role in atherogenesis. Thus, we studied effect rapeseed oil-extract components, beta-sitosterol,...
Oleanolic acid (OA) is a pentacyclic triterpenoid compound naturally found in plant kingdom. OA possesses several biological activities, which make it an interesting for scientists working the field of pharmacy and new drugs design development. The exhibits anti-inflammatory anti-oxidative effects vitro vivo, probably determine its dual function - cytoprotective cytotoxic/cytostatic activity. In this study, we focused on presentation molecular mechanisms compound's action to emphasize...
T helper 17 (Th17) cells have crucial functions in mucosal immunity and the pathogenesis of several chronic inflammatory diseases. The lineage-specific transcription factor, RORγt, encoded by RORC gene modulates Th17 polarization function, as well thymocyte development. Here we define regulatory elements at human locus thymocytes peripheral CD4+ lymphocytes, with CRISPR/Cas9-guided deletion these genomic segments supporting their role RORγt expression. Mechanistically, cell receptor...
The aim of the study was to analyze consequence silencing genes coding for key subunits telomerase complex, i.e. TERT, TERC and TP1 in human breast cancer MCF7 MDA-MB-231cells. transfection performed using Lipofectamine2000 pooled siRNAs. cytotoxic and/or antiproliferative effect siRNA measured by SRB assay, cell cycle analysed flow cytometry DNA fragmentation TUNEL analysis. Telomerase activity assessed TRAP, followed PAGE ELISA assays. downregulation also qPCR order estimate changes...
Miltefosine (hexadecylphosphocholine) is used for topical treatment of breast cancers. It has been shown previously that a high percentage carcinomas express MDR1 or MRP. We investigated the sensitivity MDR1-expressing cells to with miltefosine. show overexpressing (NCI/ADR-RES, KB-8-5, KB-C1, CCRF/VCR1000, CCRF/ADR5000) were less sensitive miltefosine when compared parental cell lines. HeLa transfected exhibited resistance compound, indicating expression this gene sufficient reduce The was...
Phytosterols have been proposed to act as potent anticancer agents. However the mechanism of their action has not elucidated yet. Thus, aim our study was determine whether plant sterols and thermal processing products (in physiological concentration range) could influence viability cancer cells thus be considered positive diet complements. Additionally we decided potential specificity those natural compounds against showing high multidrug resistance. In this show that cytotoxic effect...
Autophagy is important in the regulation of survival and death signaling pathways cancer. PKCϵ revealed high transforming potential ability to increase cell migration, invasion, metastasis. Zapotin (5,6,2′,6′-tetramethoxyflavone), a natural flavonoid, showed chemopreventive anticancer properties. Previously, we reported that downmodulation induced level by zapotin was associated with decreased migration increased apoptosis HeLa line containing doxycycline-inducible constitutively active...
The CXCL12-3' G801A transition (rs1801157) has been associated with the incidence of breast cancer. However, contribution polymorphisms in cancer development and progression controversial. Therefore, we examined polymorphic variants patients (n = 193) controls 199) a Polish cohort. We observed trend slightly increased presence AA GA genotypes CXCL12-3'A allele frequency compared healthy individuals. these differences between cases were not statistically significant. Odds ratio (OR) for A/A...