A5048130240- FOXO transcription factor regulation
- Carcinogens and Genotoxicity Assessment
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Pituitary Gland Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Mycotoxins in Agriculture and Food
- Growth Hormone and Insulin-like Growth Factors
- PARP inhibition in cancer therapy
- Bioactive Compounds and Antitumor Agents
- Autism Spectrum Disorder Research
- RNA Interference and Gene Delivery
- Down syndrome and intellectual disability research
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Prenatal Screening and Diagnostics
- Aluminum toxicity and tolerance in plants and animals
- Pesticide and Herbicide Environmental Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Pesticide Exposure and Toxicity
- Cardiac Ischemia and Reperfusion
Erciyes University
2016-2025
Kayseri Eğitim ve Araştırma Hastanesi
2007-2024
The University of Texas MD Anderson Cancer Center
2016-2021
Cell Medica (Switzerland)
2020
Bozok Universitesi
2019
// Zuhal Hamurcu 1, 2, 3 , Ahmed Ashour 1 Nermin Kahraman Bulent Ozpolat 4 Department of Experimental Therapeutics, The University Texas MD Anderson Cancer Center, Houston, Texas, USA 2 Faculty Medicine, Medical Biology, Erciyes University, Kayseri, Turkey Betül-Ziya Eren Genome and Stem Cell Center for RNA Interference Non-Coding RNA, Correspondence to: Ozpolat, e-mail: Bozpolat@mdanderson.org Keywords: breast cancer, triple-negative TNBC, FOXM1, eEF2-kinase Received: June 16,...
Autophagy plays a complex role in cancer progression, serving as both tumor suppressor and promoter, depending on the context. In triple-negative breast (TNBC), particularly aggressive subtype with limited therapeutic options, autophagy inhibition has emerged promising strategy to enhance efficacy of chemotherapy. This study investigates synergistic effects suppression using LC3 siRNA-loaded "smart" nanoparticles (LC3siRNA-NPs) combination doxorubicin (DOX) overcome chemoresistance TNBC. We...
Background: Triple Negative Breast Cancer (TNBC) is an aggressive and highly heterogeneous subtype of breast cancer associated with poor prognosis. A better understanding the biology this complex needed to develop novel therapeutic strategies for improvement patient survival. We have previously demonstrated that Thymoquinone (TQ), major phenolic compound found in Nigella sativa, induces anti-proliferative anti-metastatic effects inhibits vivo tumor growth orthotopic TNBC models mice. Also,...
Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) is one of the deadliest pathogenic bacteria. Using photothermal therapy (PTT) to eradicate MRSA bacteria easily and effectively, it has directed this bacterium be destroyed. Gold nanorods (AuNRs), which are nanoparticles that provide PPT, were synthesized removed from CTAB molecule reduce toxic effect caused by CTAB. Subsequently, mercaptophenylboronic acid (MFBA) coated AuNRs used in develop a targeting agent selectively eliminate...
Abstract Some mycotoxins produced by microfungi are capable of causing disease and death in animals humans. In the present study, mycotoxin citrinin (CTN) was evaluated for its genotoxic effects to human peripheral blood lymphocytes from six different individuals. Lymphocyte cultures were treated 48 h with CTN at concentrations between 10 100 µ m . also incubated 0.1 mitomycin c (MMC) as a positive control, 0.5% absolute ethanol vehicle control. caused significant concentration‐dependent...
Traumatic brain injury (TBI) is a major health problem affecting millions of people worldwide and leading to death or permanent damage. TBI affects the hypothalamic-pituitary-adrenal (HPA) axis either by primary hypothalamic-hypophyseal region secondary vascular damage, brain, and/or pituitary edema, vasospasm, inflammation. Neuroendocrine dysfunctions after have been clinically described in all hypothalamic-pituitary axes. We established mild (mTBI) rats using controlled cortical impact...
Abstract Breast cancer is one of the most common types causing high mortality rates among women worldwide. This study was aimed to evaluate effect Pistacia terebinthus (terebinth) resin extract (TRE) on MDA-MB-231 breast cell line. In study, cytotoxic dose in cells evaluated by MTS analysis. The TRE apoptosis examined Hoechst staining. Caspase-3 and cleaved caspase-3 protein expressions were determined western blot Based outcomes our analysis, IC50 calculated at 56.54 μg/mL during a 24-h...
Abstract Purpose Traumatic Brain Injury (TBI) poses a significant global health burden, with Mild TBI (mTBI) being the most prevalent form. triggers activation of hypothalamic–pituitary–adrenal (HPA) axis, which in turn affects hypothalamic-pituitary–gonadal (HPG) axis regulating oogenesis and spermatogenesis. In this study, we investigated impact mTBI on sperm genome integrity using repetitive (r-mTBI) mouse model. Methods We assessed telomere length (TL), free TERRA (fTERRA), DNA/RNA...
Introduction: Gastric cancers (GC) are one of the main causes cancer-related deaths worldwide. Despite dizzying progress in diagnostic and therapeutic strategies, many GC cases diagnosed at advanced stages. Various signaling pathways have been identified to play vital roles GC. Although importance these has demonstrated, further clinical studies needed. Therefore, expression some proteins tumoral peri-tumoral microenvironments examined this study. Methods: Protein levels were analyzed using...
Polycystic ovary syndrome (PCOS) has recently been linked with genomic instability and DNA damage. The aim of this study was to test damage in women PCOS, using two different methods for assessing both chromosome base level. performed on 36 newly diagnosed PCOS 29 healthy as controls. micronucleus (MN) analysis used a biomarker chromosomal/DNA peripheral lymphocytes by cytokinesis-block method. 8-hydroxydeoxyguanosine (8-OHdG) levels reliable marker oxidative were measured plasma an ELISA...
The objective of the current study is to determine effects regular wrestling exercise oxidative DNA damage and antioxidant parameters. findings have shown that 8-hydroxy-2’-deoxyguanosine (8-OHdG) obtained from wrestlers in basal status were significantly lower than those sedentary ( p = .001). In contrast, Nitric oxide (NO) Paraoxonase-1 (PON1) remarkably higher (respectively, .001, .024). While NO increased immediately after a 1.5-h compared with before .002), no differences was found...
Thyroid nodules are a common clinical problem worldwide. Although thyroid cancer accounts for small percentage of nodules, the majority benign. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) levels marker oxidative stress and play key role in initiation development range diseases types. This study evaluates cytokinesis-block micronucleus cytome (CBMN-cyt) assay parameters plasma 8-OHdG their association with nodule size hormones patients multinodular goiter. The included 32 goiter 18 age- sex-matched...
Abstract FOXM1, a proto-oncogenic transcription factor, plays critical role in cancer development and treatment resistance cancers, particularly breast cancer. Thus, this study aimed to identify potential FOXM1 inhibitors through computational screening of drug databases, followed by vitro validation their inhibitory activity against cells. In silico studies involved pharmacophore modeling using the inhibitor, FDI-6, virtual DrugBank Selleckchem databases. The selected drugs were prepared...