A5087855882- Vitamin D Research Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Cancer-related Molecular Pathways
- Hedgehog Signaling Pathway Studies
- Metal complexes synthesis and properties
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
Istanbul University
2016-2025
Bezmiâlem Vakıf Üniversitesi
2020
Sağlık Bilimleri Üniversitesi
2020
Türkisch-Deutsche Universität
2020
Creative Commons
2020
Institute of Molecular Medicine
2020
HUN-REN Institute of Experimental Medicine
2018-2019
Oxidative stress is characterized by the deregulation of redox state in cells, which plays a role initiation various types cancers. The activity galectin-1 (Gal-1) depends on cell and microenvironment. Gal-1 expression has been related to many different tumor types, as it important roles several processes involved cancer progression, such apoptosis, migration, adhesion, immune response. erythroid-2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) signaling pathway crucial...
This study was aimed to investigate the effect of weight loss by bariatric surgery on level anti-Mullerian hormone (AMH) in morbidly obese female patients with or without polycystic ovary syndrome (PCOS). prospective includes 70 females, obese, and fertile reproductive age. All were evaluated determine changes weight, body mass index (BMI), serum AMH, other biochemical parameters at end six months. The mean levels preop postop AMH 1.66±0.87 ng/ml 5.99±1.39 PCOS group; 1.35±0.76 6.23±1.47...
Introduction: Gastric cancers (GC) are one of the main causes cancer-related deaths worldwide. Despite dizzying progress in diagnostic and therapeutic strategies, many GC cases diagnosed at advanced stages. Various signaling pathways have been identified to play vital roles GC. Although importance these has demonstrated, further clinical studies needed. Therefore, expression some proteins tumoral peri-tumoral microenvironments examined this study. Methods: Protein levels were analyzed using...
Abstract This study investigates whether the circulating miR‐155, let‐7c, miR‐21, and PTEN levels to be used in differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) breast cancer (BC). Forty‐five BC, 50 IGM, 48 healthy volunteers were included study. Serum miR‐21 expression was significantly higher BC (fold change = 2.42) IGM group 1.33) compared control ( p < .001). miR‐155 let‐7c lower both groups than 1.976; .001) .001); In addition radiological data, serum...
Abstract This study was designed to investigate, in the Turkish population, an association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and risk gastric colorectal cancer. Our carried out 35 patients with cancer (20 men, 15 women) 144 controls (75 69 52 (31 21 women). MTHFR genotypes were determined by polymerase chain reaction, restriction fragment length techniques. No differences observed distribution or allele frequencies cases versus controls. The homozygous...
Stage has been defined as the major prognostic factor in resected non-small cell lung cancer (NSCLC). However, there is some evidence that indicates season of operation could play a role survival patients. Between January 1995 and June 2008, 698 (621 men 77 women) patients who had undergone pulmonary resection for NSCLC were evaluated. Patients analysed according to surgical-pathological stages month year which they operated. Vitamin D receptor (VDR) polymorphism was also 62 The median time...
Endothelial nitric oxide synthase (eNOS), encoded by the NOS3 gene, has been suggested to play an important role in uncontrolled cell growth several cancer types. The objective of this study was evaluate Glu298Asp polymorphism bladder susceptibility a Turkish population. We determined genotypes 66 cases and 88 healthy controls. Genotypes were polymerase chain reaction-restriction fragment length analysis. A significant association for heterozygotes T allely found between controls cancer,...
Nitric oxide synthase (eNOS/NOS3) is responsible for the endothelial synthesis of nitric (NO • ). G894T polymorphism leads to amino acid substitution from Glu298Asp that causes lower NOS3 activity and basal NO production in 894T (298Asp) allele carriers compared with GG homozygotes. acts as an antioxidant protecting against Fenton’s reaction which generates highly reactive hydroxyl radicals. Allelic variation may influence individual’s risk laryngeal cancer (LC). In current study we have...
Based on the exciting insights gleaned from decades of ground-breaking research, it has become evident that deregulated signaling pathways play instrumental role in cancer development and progression. Interestingly discovery non-coding RNAs revolutionized our understanding related to transcription, post-transcription translation. Modern era witnessed landmark discoveries field molecular RNA biology undergone tremendous broadening. There been an exponential growth list publications...
Background/Aim: Colorectal cancer (CRC) is one of leading cancers in terms incidence and mortality. Interaction tumor cells with the surrounding microenvironment plays a crucial role development progression CRC. Many pathways such as kynurenine pathway, OX40/OX40L-mediated signaling microRNAs targeting PD-L1 may be involved CRC by affecting T cell activation, thus creating an immune-deficient microenvironment. Herein, our goal was to assess association between plasma levels tryptophan (TRP),...
CDNK2 p16 plays a pivotal role in G1/S transition by regulating the p53 pathway, which was regulated nuclear oncoprotein, mouse double minute 2 (MDM2). Overexpression of MDM2 gene has been shown number tumor types, its amplification is found to associate with accelerated development and failure treatment both hereditary sporadic cancers. Although genetic association studies have revealed relationship between certain polymorphisms genes that play important roles progression colorectal cancer...
Objective . The genetic structural alterations in the majority of somatotroph adenomas are not clarified and search for novel candidate genes is still a challenge. We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms acromegaly. Design, Patients, Methods 52 acromegaly patients (mean age<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn>45.7</mml:mn><mml:mo>±</mml:mo><mml:mn>1.9</mml:mn></mml:math>years) 83 controls...
The Wnt pathway alterations have been identified in colorectal and many other cancer types. It has reported that galectin-3 (which is encoded by the LGALS3 gene) alters signaling mechanism Wnt/ β-catenin binding to colon cancers. AXIN1 mainly responsible for assembly of destruction complex pathway. This study investigated relationship rs4644 rs4652 variants gene rs214250 histopathological clinical properties. Our included a total 236 patients, whom 119 had (42 women, 77 men) 117 were healthy...