The purpose of this study was to determine the effects diabetic complications on oxidation proteins, lipids, and DNA investigate relationship between oxidative damage markers clinical parameters.The group consisted 69 type 2 patients (20 without complication, 49 with complication) who attended internal medicine outpatient clinics Istanbul Education Research Hospital 19 healthy control subjects. In serum samples both subjects, 8-hydroxy-2'deoxyguanosine (8-OHdG), as a marker damage,...

Our aim in this study was to investigate the relationship between serum ischemia modified albumin (IMA) levels with oxidative stress parameters [protein carbonyl (PCO), advanced protein oxidation products (AOPPs), malondialdehyde (MDA), total nitric oxide (NOx), prooxidant-antioxidant balance (PAB), and ferric reducing of antioxidant power (FRAP)] breast cancer (BC) colon (CC).In total, 90 patients undergoing surgical treatment for BC (n = 45) or CC 35 healthy controls were included...

Objective Juvenile SLE (jSLE) is an autoimmune disease characterised by the presence of high levels autoantibodies, predominantly targeting nuclear antigens, resulting in a breakdown self-tolerance. However, its pathogenesis multifactorial and poorly understood. The aim this study was to evaluate potential factor-kappa B (NF-κB) peroxisome proliferator-activated receptor-gamma (PPAR-γ) as biomarkers for jSLE. Methods In study, serum NF-κB PPAR-γ were determined immunoassay 42 patients with...

Affection of vascular structures is a known complication in diabetes and prediabetes. Subclinical atherosclerosis begins to develop years before both cardiovascular cerebrovascular diseases become symptomatic. The aim this study was evaluate the relationship between circulating oxidized LDL (oxLDL), soluble lectin-like (sLOX)-1 proprotein convertase subtilisin/kexin type 9 (PCSK9) levels carotid intima-media thickness (CIMT) patients with prediabetes T2DM. We recruited 50 T2DM macrovascular...

The aims of this study were to describe the clinical, radiological and immunological features a population sarcoidosis patients analyse chitinase-3-like protein 1 (YKL-40), soluble interleukin-2 receptor (sIL-2R), neopterin concentrations adenosine deaminase (ADA) activity in serum these order understand their potential as disease markers. Fifty-nine affected by chronic sarcoidosis, active (20 patients) inactive (39 phase according laboratory criteria studied. Serum YKL-40, sIL-2R,...

The aim of the present study was to determine systemic levels oxidative stress markers, such as ischemia-modified albumin (IMA), advanced oxidation protein products (AOPP), ferric reducing antioxidant power (FRAP) and prooxidant-antioxidant balance (PAB), clarify redox homeostasis in patients with Alzheimer's disease, compare them mentally healthy persons same age.A total 38 disease (AD) 34 sex- age-matched control subjects were included this study.The had significantly higher AOPP, IMA PAB...

Sepsis is a complex inflammatory syndrome with diverse etiology and wide spectrum of severity. The aim this study was to investigate whether mediators, in comparison oxidative parameters, are associated severity sepsis.Plasma neopterin, adenosine deaminase (ADA), vascular cell adhesion molecule (VCAM), intracellular (ICAM), interleukin (IL)-1, IL-6, tumor necrosis factor alpha (TNF-α), as serum nitric oxide (NOx), nitrotyrosine (NT), oxidized LDL (oxLDL) levels, paraoxonase 1 (PON1)...

Oxidative stress and hypoxia play an important role in the pathogenesis of various cardiovascular diseases. We aimed to evaluate effectiveness sacubitril/valsartan (S/V) Empagliflozin (EMPA) on hypoxia-inducible factor-1α (HIF-1α) oxidative H9c2 rat embryonic cardiomyocyte cells.BH9c2 cells were treated with methotrexate (MTX) (10-0.156 μM), empagliflozin (EMPA; 10-0.153 µM) (S/V; 100-1.062 for 24, 48 72 h. The half maximum inhibitory concentration (IC50) excitation (EC50) values MTX, EMPA...

We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) metabolic syndrome (MetS).In 180 individuals, including controls patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), RBP-4, using ELISA kits.While hsCRP, PTX-3, IL-33, RBP-4...

To investigate whether the circulating miR-1 (microRNA-1) and miR-21 expression might be used in diagnosis of heart failure (HF) silent coronary artery disease (SCAD) asymptomatic type 2 diabetes mellitus (T2DM) patients to explore relationship these miRs with N-terminal pro-brain natriuretic peptide (NT-proBNP) galectin-3. One hundred thirty-five consecutive T2DM 45 matched control subjects were enrolled study. This study consisted following four groups: group (mean age: 60.23 ± 6.27 years,...

Objective The limited predictive effect of genotype on familial Mediterranean fever (FMF) phenotype suggests that epigenetic factors and alternative mechanisms may cause IL-1β release could contribute to phenotypic heterogeneity. objective this study was examine the role levels miR-21-5p, cathepsin B pyrin levels, which were identified as potential causing through use bioinformatics tools, in pathogenesis FMF their relationship with disease severity. Materials methods 50 paediatric patients...

Objectives Childhood-onset systemic lupus erythematosus (cSLE) is a multisystemic autoimmune disease characterized by inflammatory organ damage means of vasculitis. Pentraxin-3 (PTX3) expressed locally at the sites processes, predominantly from endothelial cells. In adult studies, PTX3 has shown to be an indicator active vasculitis both in large-vessel and small-vessel vasculitides, as well SLE. Moreover, SLE it found correlated with activity, some clinical manifestations laboratory...

Abstract This study investigates whether the circulating miR‐155, let‐7c, miR‐21, and PTEN levels to be used in differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) breast cancer (BC). Forty‐five BC, 50 IGM, 48 healthy volunteers were included study. Serum miR‐21 expression was significantly higher BC (fold change = 2.42) IGM group 1.33) compared control ( p < .001). miR‐155 let‐7c lower both groups than 1.976; .001) .001); In addition radiological data, serum...

Hyperbaric oxygen (HBO) therapy may improve cholestasis, increase hepatic regeneration, and decrease oxidative stress in liver. In this study, we aimed to investigate the effects of HBO on parameters, such as total thiol groups (T-SH), protein carbonyl (PCO), antioxidant capacity (TAC) well predictive value noninvasive biochemical marker, sialic acid (SA), prolidase activity bile duct ligation (BDL)-induced damage fibrosis rats.We divided 32 adult male Sprague Dawley rats into four groups:...

Quercetin (QR) is part of a subclass flavonoids called flavonols. We aimed to investigate the effect QR on malondialdehyde (MDA), advanced oxidation protein products (AOPPs), and glutathione peroxidase (GSH-Px) activity in liver diabetic rats. compared four groups male adult Wistar albino rats: control group, an untreated treated with QR, group. Diabetes was induced by single injection streptozotocin (STZ) (50 mg/kg). Animals were kept standard condition. On 31st day study, tissue removed...

Antimicrobial peptides are effectors of host defence against infection and inflammation can encourage wound repair.The objectives this study were to investigate the plasma antimicrobial peptide LL-37 nuclear factor-kappaB (NF-κB) levels in patients with stable COPD compared a control group highlight their importance immune inflammation.One hundred thirty-eight 33 subjects enrolled study. The classified into four groups based on FEV1 (groups I-IV) also divided "low-risk high-risk" A-B [low...

The aim of this study was to evaluate the effectiveness ranolazine on hypoxia-inducible factor-1α (HIF-1α) and oxidative stress in H9c2 cardiomyocyte cells.