A5071653942- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Cell death mechanisms and regulation
- Adenosine and Purinergic Signaling
- Histone Deacetylase Inhibitors Research
- Natural Antidiabetic Agents Studies
- Dietary Effects on Health
- Atherosclerosis and Cardiovascular Diseases
- DNA Repair Mechanisms
- History and Cultural Heritage
- Islamic Thought and Society Studies
- Caveolin-1 and cellular processes
- Phagocytosis and Immune Regulation
- Legal Issues in Turkey
- Diabetes and associated disorders
- Turkish Urban and Social Issues
- Blood Coagulation and Thrombosis Mechanisms
- Genetic factors in colorectal cancer
- Phytochemicals and Medicinal Plants
- Microscopic Colitis
- Machine Learning in Bioinformatics
- Angiogenesis and VEGF in Cancer
Istanbul University
2016-2025
Istanbul University-Cerrahpaşa
2020
Macroautophagy/autophagy is an evolutionarily conserved cellular stress response mechanism. Autophagy induction in the tumor microenvironment (stroma) has been shown to support metabolism. However, cancer cell-derived secreted factors that initiate communication with surrounding cells and stimulate autophagy are not fully documented. We identified CTF1/CT-1 (cardiotrophin 1) as activator of fibroblasts breast cancer-derived carcinoma-associated (CAFs). showed CTF1 stimulated phosphorylation...
Abstract Background Obesity is among the important healthcare issues in which there an abnormal increase body fat because energy intake higher than expenditure. The Tumor Necrosis Factor (TNF)-alpha overexpression adipose tissue plays roles mediating obesity and insulin resistance. “TNF-related apoptosis-inducing Ligand (TRAIL(TNSF10))”, a member of TNF family, expressed as Type-II Transmembrane Protein with effect on development diabetes. Methods rs781673405, rs1244378045, rs767450259,...
Background: If used in the right clinical context, PCRs carry great potential rapidly diagnosing various infectious diseases. Objectives: We aimed to evaluate performance of four novel multiplex real-time PCR (qPCR) assays direct detection pathogens whole blood, cerebrospinal fluid, respiratory specimens, and stool samples. Methods: Spiked negative specimens were for evaluation. Clinical samples comparative assessment culture molecular analyses simultaneously examined. RINATM robotic nucleic...
Objective: We aimed to analyze the changes in metabolic parameters after administration of irisin obese female mice. Materials and Methods: Sixty mice aged 5–6 weeks were randomized into three groups as irisin, exercise, control. The control group remained sedentary, whereas exercise started free wheel exercising 6 start study. received 20 weeks. All sacrificed at 22nd week study, obesity-related analyzed. Results: There was no significant difference between weight gain (P > 0.05). By...
Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. <TEX>${\beta}3$</TEX> integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is surface glycoprotein important for invasion angiogenesis. The aim this study was investigate whether specific genetic polymorphisms ICAM-1 ITGB3 could be associated with cancer...
Diabetes mellitus and obesity are very similar in terms of pathogenesis pathophysiology. Most obese patients have adipose tissue dysfunction caused by genetic environmental factors. Adipose is the source adipokines secreted from adipocytes. Vaspin, Visfatin Chemerin discovered recent years. The study consists 43 non-diabetic 51 diabetic individuals. PCR-RFLP method agarose gel electrophoresis techniques were used to detect gene polymorphisms rs17173608, Vaspin rs2236242 rs2110385 DNA...
Objective: Obesity and acute coronary syndrome (ACS) are common health problems of recent years.There many candidate genes related to the genetic infrastructure ACS obesity.This study aimed investigate association Leptin glutamine arginine substitution (Gln223Arg), Resistin-420 Cytosine/Guanine (C/G), proliferator-activated receptor-gamma (PPAR-γ) proline alanine (Pro12Ala) polymorphisms in obese patients with Turkish population.Methods: Fifty concurrently diagnosed 42 healthy controls were...
Aim: Genetic and environmental factors are very important in the formation of type 2 diabetes mellitus (T2DM).Tissue inhibitors matrix metalloproteinases (TIMPs) play central roles inhibition extent extracellular degradation.The aim this study is to investigate serum levels gene polymorphisms TIMP-1 TIMP-2, their effects on T2DM Turkish population.Material Methods: One hundred seventeen patients with 127 healthy controls were included study.TIMP-1 372 T>C, TIMP-2 303C>T, 418 G>C determined...
<title>Abstract</title> Obesity, a global pandemic with multiple causes, significantly impacts physical health. Factors such as genetics, ethnicity, inactivity, excessive calorie intake, stress, and socioeconomic status contribute to the development of metabolic disorders like diabetes, cardiovascular disease, syndrome. This study was designed examine genotype differences PPAR γ (rs1801282) TRHR (rs16892496) polymorphisms known be associated obesity in different populations determine role...
Adipocyte gene expression is altered in obese individuals through multiple metabolic and biochemical pathways. In this study, we aimed to examine the of resistin (Retn), amylin (Iapp), dopamine receptor domain 5 (Drd5) genes previously suggested contribute pathogenesis obesity, albeit controversially. We also determine effects on short long-term mRNA levels these mice, induced with high-fat diet (HFD).Two obesity models were created our study: group T1 (20 mice) was fed HFD (60% fat) for 3...
Aim: To investigate the possible effects of polymorphisms in genes encoding some important antioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), endothelial NOS (eNOS) and catalase (CAT) patients with polycystic ovary syndrome (PCOS).Methods: Peripheral blood 100 PCOS healthy control group were collected, Polymorphisms related was investigated by using polymerase chain reaction-restriction fragment length polymorphism. In addition, biochemical values...
Abstract Aim ATM, RAD51 and TP73 are genes that take part in DNA repair pathways. The aim of this prospective case-control study was to determine the genotype allele distributions ATM 5′-UTR G/A, 135 G/C GC/AT polymorphisms their relationship with clinical parameters Turkish colorectal cancer (CRC) patients. Material methods One hundred four CRC patients 113 healthy individuals were included as control. polymerase chain reaction-restriction fragment length polymorphism techniques used....
Objective: The ABCB1/MDR1 is a 170-kDa transporter protein called P-glycoprotein (Pgp) which has been associated with the transport of cellular lipids and drugs. Recent studies focused on MDR1, its effects lipid transport, show that constitutive expression P-gp in normal tissues plays an important role drug disposition response. In addition, it known some polymorphisms MDR1 gene alter P-gp. This study aims to investigate C3435T C1236T dyslipidemia diabetic patients. Material methods:...