A5007741115- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Gastric Cancer Management and Outcomes
- Gyrotron and Vacuum Electronics Research
- SARS-CoV-2 and COVID-19 Research
- Poxvirus research and outbreaks
- Bone Tissue Engineering Materials
- COVID-19 Clinical Research Studies
- Ovarian cancer diagnosis and treatment
- Animal Virus Infections Studies
- Periodontal Regeneration and Treatments
- Cancer Treatment and Pharmacology
- Herpesvirus Infections and Treatments
- Colorectal Cancer Treatments and Studies
- Orthopaedic implants and arthroplasty
- Bacillus and Francisella bacterial research
- Microtubule and mitosis dynamics
- Glioma Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Endometrial and Cervical Cancer Treatments
- SARS-CoV-2 detection and testing
Ministry of Health of the Russian Federation
2015-2023
Russian Cancer Research Center NN Blokhin
2014-2019
Lomonosov Moscow State University
2019
Academy of Medical Sciences
2014
Cancer Research Center
2014
Since the beginning of 2021 year, all main six vaccines against COVID-19 have been used in mass vaccination companies around world. Virus neutralization and epidemiological efficacy drop obtained for several B.1.1.7, B.1.351 P.1, B.1.617 genotypes are concern. There is a growing number reports on mutations receptor-binding domain (RBD) increasing transmissibility virus escaping neutralizing effect antibodies. The Sputnik V vaccine currently approved use more than 66 countries but its...
Mass vaccination campaigns against COVID-19 affected more than 90% of the population in most developed countries. The new epidemiologic wave has been ongoing since end 2021. It is caused by a virus variant B.1.1.529, also known as "Omicron" and its descendants. effectiveness major vaccines Omicron not known. purpose this study to evaluate efficacy Sputnik V vaccine. main goal assess protection hospitalization period dominance. We conducted our based on large clinical center Moscow (Russia)...
WHO has declared the outbreak of monkeypox as a public health emergency international concern. In less than three months, was detected in more 30 000 people and spread to 80 countries around world. It is believed that immunity formed smallpox vaccine can protect from infection with high efficiency. The widespread use Vaccinia virus not been carried out since 1980s, which raises question level residual among population identification groups requiring priority vaccination. We conducted...
The combination of fluoropyrimidines with oxaliplatin is one the standard first line chemotherapy metastatic colorectal cancer (mCRC). In Russian research center was performed a full cycle production drug Oxaliplatin-RONC®, showed equivalence to Eloxatin® in vitro and vivo. main purpose this study evaluate therapeutic Oxaliplatin-RONC ® mFOLFOX6 as patients mCRR. second compare safety drugs. A total 59 were enrolled study. Patients assigned 1:1 ratio receive up 9 cycles Oxaliplatin-RONC® or...
Introduction. In patients with neuroendocrine neoplasms it is necessary to search for new prognostic factors identify a subgroup of who will benefit from drug treatment. Aim. The aim the study was an optimization Aranoza-based therapy in by using both morphological and clinical as predictors treatment efficacy. Materials methods. A total 122 were enrolled assessed radiological response (RECIST 1.0) progression-free survival. Results. Aranoza its combinations had similar localization...
The paper gives recent data on the use of target agents, such as erlotinib, gefitinib, cetuximab, bevacizumab, and sorafinib in advanced cancer cervix uteri (CCI). Approaches using drugs combination with chemotherapy are greatest interest. A spec- trum molecular biomarkers (epidermal vascular growth factors) CCI its correlation prognosis treatment response shown. number adverse relations caused by agents considered.
Somatostatin analogs plays a key role in the treatment of disseminated well-differentiated functioning and nonfunctioning neuroendocrine tumors (NET). Its ingibit hormonal activity NET by binding to somatostatin receptors, have antiproliferative effect, increase median time progression. Approximately 10% patients significant side-effects when used octreotide. Octreotide lanreotide differ structure. Intolerance one drug, it may be assigned another.
Aranoza (3-a-L-arabinopyranosyl-1-methyl-nitrosourea) is nitrosourea derivative, as streptozotocin STZ. O6-methylguanine DNA methyltransferase (MGMT) an enzyme involved in chemotherapy resistance to alkalyting agents. Material and methods. There were observed 117patients with neuroendocrine neoplasms (NENs) received Aranoza-based therapy. They included 52 cases pancreatic tumors (P-NETs), patients non-pancreatic (notP-NETs, 13 NET metastases without revealed primary tumor focus). was...
Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, number TBE cases increase annually. There no specific treatment for infection, thus vaccination main preventive measure. Despite existence several inactivated vaccines currently being licensed, development new remains a leading priority countries endemic this pathogen. Here we report recombinant made by...
Poorly differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare malignancies, most of which characterized by aggressiveness, a tendency to rapid metastasis and an unfavorable prognosis even when localized. In 2017 World Health Organization (WHO) updated classification GEP NENs recognized the category well-differentiated pancreatic NET G3, associated with Ki‑67 index usually over 20%. The upper level is not defined. Usually it 55%. Highgrade poorly defined as...
The treatment efficacy and toxicity profile was evaluated in 33 patients with highly differentiated neuroendocrine tumors NEO (G1, G2), who received sunitinib therapy various dose regimens. Stable disease achieved 24 (72.7%), partial effect 1 patient (3%). of did not depend on the used regimen. consistent international study data.
Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC number TBE cases increase annually. There no specific treatment for infection, thus vaccination main preventive measure. Despite existence several inactivated vaccines currently being licensed, development new remains a leading priority countries endemic this pathogen. Here we report recombinant made by...