A5070967582- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- interferon and immune responses
- Antimicrobial Peptides and Activities
- Viral Infections and Vectors
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Hepatitis B Virus Studies
- SARS-CoV-2 detection and testing
- NF-κB Signaling Pathways
- Hematopoietic Stem Cell Transplantation
- Nosocomial Infections in ICU
- Macrophage Migration Inhibitory Factor
- Toxin Mechanisms and Immunotoxins
- Seaweed-derived Bioactive Compounds
- Immune Cell Function and Interaction
- Streptococcal Infections and Treatments
Ministry of Health of the Russian Federation
2014-2025
Gamalei Institute of Epidemiology and Microbiology
2013-2024
Pirogov Russian National Research Medical University
2019
Russian Medical Academy of Continuous Professional Education
2019
National Research Centre
2018
Russian Academy of Sciences
2010-2012
Academy of Medical Sciences
2010-2012
Since the beginning of 2021 year, all main six vaccines against COVID-19 have been used in mass vaccination companies around world. Virus neutralization and epidemiological efficacy drop obtained for several B.1.1.7, B.1.351 P.1, B.1.617 genotypes are concern. There is a growing number reports on mutations receptor-binding domain (RBD) increasing transmissibility virus escaping neutralizing effect antibodies. The Sputnik V vaccine currently approved use more than 66 countries but its...
Ebola hemorrhagic fever, also known as virus disease or EVD, is one of the most dangerous viral diseases in humans and animals. In this open-label, dose-escalation clinical trial, we assessed safety, side effects, immunogenicity a novel, heterologous prime-boost vaccine against Ebola, which was administered 2 doses to 84 healthy adults both sexes between 18 55 years. The consists live-attenuated recombinant vesicular stomatitis (VSV) adenovirus serotype-5 (Ad5) expressing envelope...
While the world is experiencing another wave of COVID-19 pandemic, global vaccination program hampered by an evident shortage in supply licensed vaccines. In effort to satisfy vaccine demands we developed a new single-dose based on recombinant adenovirus type 26 (rAd26) vector carrying gene for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein - "Sputnik Light".We conducted open label, prospective, non-randomised phase 1/2 trial aimed assess safety,...
Significance Post-traumatic sterile inflammation is the first necessary step of wound healing. In addition, underlies pathogenesis a multitude common diseases, such as allergies and autoimmune diseases. The molecular mechanisms underlying are still not fully understood. Here, we show that receptor Mincle (Clec4e), expression which highly induced in skin response to damage, recognizes cholesterol sulfate, molecule abundant epidermal layer skin, subsequently inducing pro-inflammatory response....
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by neurotoxin (BoNT) and characterized damage to nervous system. In an effort develop novel C. immunotherapeutics, camelid single-domain antibodies (sdAbs, VHHs, or nanobodies) could be used due their unique structure characteristics. this study, VHHs were produced using phage display technology. A total 15 different monoclonal selected based on comlementarity-determining region 3 (CDR3)...
Toll-like receptors (TLRs) are major components of the innate immune system that recognize conserved molecular structures pathogens (pathogen-associated patterns; PAMPs). TLRs found in many different cell types, ranging from epithelial to immunocompetent cells. TLR binding triggers expression several adapter proteins and downstream kinases, leading induction key pro-inflammatory mediators. This results activation both response (elevated antiapoptotic proteins, proinflammatory cytokines,...
The new Omicron variant of SARS-CoV-2, first identified in November 2021, is rapidly spreading all around the world. has become dominant SARS-CoV-2. There are many ongoing studies evaluating effectiveness existing vaccines. Studies on neutralizing activity vaccinated sera against currently being carried out laboratories. In this study, we have shown SARS-CoV-2 compared to reference Wuhan D614G individuals with two doses Sputnik V up 6 months after vaccination and who experienced infection...
Binding of pattern recognition receptors (PRRs) by pathogen-associated molecular patterns (PAMPs) activates innate immune responses and contributes to development adaptive immunity. Simultaneous stimulation different types PRRs can have synergistic immunostimulatory effects resulting in enhanced production molecules that mediate immunity such as inflammatory cytokines, antimicrobial peptides, etc. Here, we evaluated the impact combined from families on generating alum-based vaccine...
Pathogen recognition receptors (PRRs) are essential components of host innate immune systems that detect specific conserved pathogen-associated molecular patterns (PAMPs) presented by microorganisms. Members two families PRRs, transmembrane Toll-like (TLRs 1, 2, 4, 5, and 6) cytosolic NOD (NOD1 NOD2), stimulated upon various bacterial PAMPs. Such stimulation leads to induction a number defense reactions, mainly triggered via activation the transcription factor NF-κB. While coordination...
The Ebola virus disease (EVD) is one of the most dangerous infections affecting humans and animals. first EVD outbreaks occurred in 1976 Sudan Zaire. Since then, more than 20 have occurred; largest which (2014-2016) evolved into an epidemic West Africa claimed lives 11,000 people. Although vaccination effective way to prevent epidemics, there was no licensed vaccine for at beginning latest outbreak. development vaccines started 1980 has come a long technological way, from inactivated...
Previously we demonstrated that the resection of primary 4T1 tumors only slightly prolongs mouse survival, but importantly, creates a "window opportunity" with attenuated suppressor cell and increased activated T populations. This suggests additional activation immune system by immunostimulatory agents during this period may enhance anti-tumor immunity potentially eradicate micro-metastatic disease in stringent model. We hypothesized immunostimulator Immunomax®, which is comprised...
To protect young individuals against SARS-CoV-2 infection, we conducted an open-label, prospective, non-randomised dose-escalation Phase 1/2 clinical trial to evaluate the immunogenicity and safety of prime-boost “Sputnik V” vaccine administered at 1/10 1/5 doses adolescents aged 12–17 years. The study began with vaccination older cohort (15-to-17-year-old participants) lower (1/10) dose then expanded whole group (12-to-17-year-old participants). Next, was used according same scheme. Both...
Although the immunogenicity of clinically approved COVID-19 vaccines remains under intensive investigation, little is still known about parameters long-term immune responses. In this paper, we present for first time humoral immunity studied in phase 1-2 open-label clinical trial Sputnik Light vaccine, with a special focus on late follow-up points (90 and 180 days). For most accurate assessment post-vaccination (titer avidity index antigen-specific antibodies against RBD domain SARS-CoV-2),...
The mechanisms underlying the complex and multistage wound-healing process are not yet completely understood. One of most important intriguing questions remaining is effect interactions between wounds microflora that present in wounds. In this report, we describe first study treating murine skin with topical bacterial lipopolysaccharide (LPS), main exogenous ligand Toll-like receptor 4. Our findings demonstrate LPS treatment strongly affects by accelerating resolution inflammation,...
HIV-induced immune suppression results in the high prevalence of HIV/AIDS-associated malignancies including Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer. HIV-infected people are also at an increased risk “non-AIDS-defining” not directly linked to but associated with viral infections. Their incidence is increasing despite successful antiretroviral therapy. The mechanism behind this phenomenon remains unclear. Here, we obtained daughter clones murine mammary gland adenocarcinoma...
Abstract The new variant Omicron (B.1.1.529) of SARS-CoV-2, first identified in November 2021, is rapidly spreading all around the world. becomes dominant SARS-CoV-2. There are many ongoing studies evaluating effectiveness existing vaccines. Studies on neutralizing activity vaccinated sera against currently being carried out laboratories. In this study, we have shown SARS-CoV-2 compared to reference Wuhan D614G (B.1) individuals with 2 doses Sputnik V or BNT162b2 different time points up 6...
Although unprecedented efforts aiming to stop the COVID-19 pandemic have been made over past two years, SARSCoV-2 virus still continues cause intolerable health and economical losses. Vaccines are considered most effective way prevent infectious diseases, which has reaffirmed for COVID-19. However, in context of continuing spread because insufficient vaccination coverage emergence new variants concern, there is a high demand strategy amendment. The ability elicit protective immunity at entry...
Introduction. Many different vaccines for the prevention of COVID-19 have received emergency use approval in shortest possible time. Due to high rate variability pathogen, this study we analyzed structural proteins SARS-CoV-2 virus and compared their protective potential protecting animals from COVID-19. The aim was compare Materials methods. used study. Transgenic mice B6.Cg-Tg(K18-ACE2)2Prlmn/J (F1) were as model animals. Recombinant adenoviral vectors rAd5-S, rAd5-N, rAd5-M immunization...
Background Ebola virus disease (EVD) is one of the most dangerous and lethal diseases affecting humans. There are several licensed vaccines against EVD, but it remains priority for research development effective vaccines. Methods A double-blind randomized placebo-controlled trial was performed to evaluate safety immunogenicity rVSV- rAd5-vectored vaccine GamEvac-Combi in healthy adults both sexes between 18 60 years. Safety were assessed during observation period 12 months. Immunogenicity...