A5062546066- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Human Health and Disease
- Drug-Induced Hepatotoxicity and Protection
- Long-Term Effects of COVID-19
- Healthcare Systems and Public Health
- Viral Infections and Vectors
- Diet, Metabolism, and Disease
- Viral Infections and Outbreaks Research
- Tryptophan and brain disorders
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Bacillus and Francisella bacterial research
- Dermatological and COVID-19 studies
- Pharmacological Effects of Natural Compounds
- Cytomegalovirus and herpesvirus research
- Biomarkers in Disease Mechanisms
- Zoonotic diseases and public health
S. M. Kirov Military Medical Academy
2014-2025
Purpose of the study. To evaluate psycho-emotional state in patients with chronic viral hepatitis C before and after treatment bicyclol. Materials methods. The study included 124 male aged 20 to 52 years (average 34.7 ± 6.5). were randomized into 2 groups: group I, including 83 mild moderate liver fibrosis (F1-2 according METAVIR); II – 41 severe (F3 METAVIR). After antiviral therapy direct agents, each divided subgroups: an experimental group, which was prescribed bicyclol potentiate...
Background Ebola virus disease (EVD) is one of the most dangerous and lethal diseases affecting humans. There are several licensed vaccines against EVD, but it remains priority for research development effective vaccines. Methods A double-blind randomized placebo-controlled trial was performed to evaluate safety immunogenicity rVSV- rAd5-vectored vaccine GamEvac-Combi in healthy adults both sexes between 18 60 years. Safety were assessed during observation period 12 months. Immunogenicity...
Aim. The study evaluates clinical effectiveness and safety of etiotropic antiviral medications with a direct mechanism action (Riamilovir, Ribavirin, Umifenovir) for the treatment moderate SARS-CoV-2 infection in adults. Materials methods . used data from 59 health records patients PCR-confirmed infection. Control group included 29 treated 1250 mg Riamilovir off-label per day 5 days (250 times day), comparison consisted 30 patients, who received 800 Ribavirin Umifenovir days. was assessed by...
Aim. To study the efficacy and safety of Riamilovir in patients diagnosed with acute respiratory viral infection using several dosage regimens drug. Material Methods. The clinical were evaluated based on results a study, that included 150 three comparative groups, 50 each. research groups received etiotropic antiviral therapy 1 capsule (250 mg) 3 times per day for 5 days first group; second group, off-label — days; third group who only pathogenetic treatment. Results. As result demonstrated...
To evaluate the clinical effectiveness, safety and compare incidence of hospitalization during treatment with antiviral drugs a direct mechanism action (riamilovir umifenovir) in people acute respiratory viral infections (ARVI) an outpatient setting.
Chronic hepatitis C remains one of the most important socially significant infections for world health. The use modern highly effective drugs with direct antiviral action allows to achieve a sustained virological response in patients. At same time, number cases after elimination HCV infection, progression fibrosis continues development its terminal stages and an unfavorable outcome article focuses on comorbid pathology, which is leading factor this process patients chronic who have achieved...
Аbstract. We consider the possibility of optimizing diagnosis infection caused by SARS-CoV-2 using polymerase chain reaction in a multi-specialty hospital, repurposed for treatment COVID-19 patients, example Of military medical Academy named after S.M. Kirov. The analysis scientific publications selected accordance with purpose study, analyzed data from 218 samples patients COVID-19, who were clinics Sm. Time intervals established depending on clinical forms and severity infectious process,...
Nonalcoholic fatty liver disease (NAFL) is the main cause of chronic pathologies in westernized countries. The prevalence hepatosis HIV patients about 30% and reaches 40–72% co-infected with HCV, depending on other risk factors, such as NRTI PI use ART. Therefore, NAFL diagnostics warranted HV/HCV co-infection. Besides that, for having HIV, HCV special therapeutic approaches are required to ensure body mass reduction, treatment, drug therapy NAFL.
To evaluate the clinical efficacy and safety of antiviral drug riamilovir in patients with acute respiratory viral infections (ARVI) non-coronavirus (SARS-CoV-2) etiology different dosing regimens. The study included 150 ARVI aged 18-27 years (50 received regimen 250 mg 3 times a day for 5 days, 50 off label only pathogenetic treatment). use both treatment regimens led to reduction duration inpatient treatment. shortest periods hospitalization were noted who at higher daily dosages. reduced...
The article describes action of the Infectious Diseases Service Armed Forces in national biosecurity control through leveraging experience military involvement, emergencies, infectious epidemic outbreaks, including rescue measures rendered during SARS-CoV-2 pandemic. We utilise infectiologists to exemplify medical care management under admission influx contagious patients. Principles are clarified early clinical diagnostics potentially pandemic diseases and active detection, isolation, sorting...
Given that COVID-19 is a global public health problem and almost all countries in the world have been severely affected by pandemic, research being actively pursued to better understand effects of virus on human cells. However, it not clear what changes are observed cells main gate infection – mucosa mouth nose at different clinical forms periods disease. Understanding ultra-structural cell SARS-CoV-2 targets may help clarify pathogenic aspects lower respiratory tract. In this study,...
Aim. In this study we evaluated clinical effectiveness and safety of nebulized prostacyclin in patients with Novel Coronavirus Disease (SARS-CoV-2). Materials methods: We have included 44 male moderate PCR confirmed SARS-CoV-2 infection study. Control group consisted 23 treated (PGI 2 ). besides standard therapy. compared intensiveness duration infectious intoxication syndrome, fever, cough as well SpO level, complete blood count chemokine status values. Results: Statistically significant...
Relevance: the annual incidence of acute respiratory infections (ARI) is in lead structure infectious pathology Russian Federation. One main issues development optimal strategies for prevention these diseases high-risk groups. Aim : to evaluate preventive and clinical efficacy as well safety various dosage forms interferon alpha-2b relation ARI young adults from organized Materials methods our study included 300 volunteers aged 18 20 years, 100 them were prescribed form a gel addition...
BACKGROUND: Blood-sucking mosquitoes are carriers of many human vector-borne diseases caused by viruses, bacteria, protozoa and helminths. There the results entomological studies Joint Russian-Vietnamese Tropical Research Technology Center. AIM: is to study generic species composition in South Vietnam before rainy season, when mosquito activity low. MATERIALS AND METHODS: The collection arthropods was carried out from May 12 26, 2024 two regions Vietnam: coastal mangrove reserve Can Gio area...
Aim. To evaluate the efficacy of antiviral drug riamilovir (trade name – «Triazavirin®») for prevention SARS-CoV-2 infection (COVID-19) and other acute respiratory viral infections in young people from organized groups. Materials methods. The study involved 386 individuals aged 18–22 years: 199 received at a daily dose 250 mg 15 days, while 187 did not receive prophylactic drugs. For 30 disease occurrence was monitored among volunteers. In case illness, duration, severity clinical...
The main pathogenetic aspects of non-alcoholic fatty liver disease as a comorbid factor chronic hepatitis C are considered. Non-alcoholic is currently the most common worldwide, both among adults and children. It usually accompanied by obesity, insulin resistance diabetes mellitus. includes spectrum pathologies from simple infiltration to steatohepatitis, which characterized inflammation with potential progression fibrosis cirrhosis over time. On average, occurs in 55% patients C,...
Based on the survey results in 1322 patients found that patients with hronic viral hepatitis (CVH) blastocysts are found more often than group of individuals without concomitant pathology hepatic-biliary system (28.8% vs. 5.5%, respectively). In healthy individuals the blastocyst revealed summer, peaking in July and August, while CVH Blastocystis most frequently observed winter. The high incidence of Blastocystis sp. suggests of the hepatic-biliary system fosters a supportive environment in...
The effectiveness and quality of liver biopsy in rats are applicable to the aspiration automatic system. Histological examination 240 specimens 100% cases identified portal tracts. number tracts determine stage fibrosis 1st group who underwent was performed using an 18 G aspirating needle from puncture set (Menghini type), which is 4-5, you have 2nd group, one-time guillotine soft tissue with a semi-automatic action 16G×20 cm, Italy) - 7-8 average size 0,5 1 cm. Thus, system allows get...
The aim of the study was to assess possibilities noninvasive diagnosis liver fibrosis (FIB-4 and APRI indices) in patients with CHC abdominal obesity. Materials methods. 52 men were examined. Genotype 1 determined 24 patients, genotype 3 19 2 9 patients. According severity fibrosis, divided: without (F0) - 12 weak (F1) 17 moderate (F2) 10 severe (F3) 8 cirrhosis (F4) detected 5 a biopsy, steatosis found 18 CHC. Abdominal obesity 34 Non-invasive assessed using routine FIB-4 indices. interval...
Журнал для непрерывного медицинского образования врачей Нарлапревир, ритонавир и софосбувир у пациентов с хроническим гепатитом С, инфицированных
Эффективность и безопасность 8-недельной терапии хронического гепатита С комбинацией препаратов, включающей ингибитор протеазы нарлапревир ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ 1 Санкт-Петербургское государственное бюджетное учреждение здравоохранения «Клиническая инфекционная больница имени С.П.Боткина», 195067, г.Санкт-Петербург, Российская Федерация 2 Федеральное образовательное высшего образования «Московский государственный медико-стоматологический университет А.И.Евдокимова» Министерства...
Aim . To evaluate the antifibrotic effect of bicyclol with promising clinical effects on diffuse parenchymal liver diseases. Materials and methods : We have included 40 adult male Wistar rats (weight, 180 to 200g) experimentally inducted toxic F3 stage fibrosis. Control group consisted 16 that received standart chow, experimental 24 also 30-day supply. results we used histological, biochemical, molecular genetic statistical methods. Results In interlobular fibrosis was maintained in 4,16%...
In order to estimate the frequency of detection of bacterial overgrowth syndrome in patients with chronic hepatitis C, find a possible relationship between development dysbiotic changes small intestine and over chronic hepatitis C were examined 80 (68 males and 12 females). addition standard laboratory tests for all patients was performed hydrogen breath test load of lactulose fibrogastroduodenoscopy hepatic biopsy with subsequent histological examination biopsy. It was found that syndrome,...