A5073677681- Immune Response and Inflammation
- Lipid Membrane Structure and Behavior
- Wound Healing and Treatments
- Antimicrobial Peptides and Activities
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Cytokine Signaling Pathways and Interactions
- Wnt/β-catenin signaling in development and cancer
- Bacterial Genetics and Biotechnology
- Pediatric health and respiratory diseases
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Viral Infections and Outbreaks Research
- Glycosylation and Glycoproteins Research
- Tuberculosis Research and Epidemiology
- Endometriosis Research and Treatment
- Probiotics and Fermented Foods
- HER2/EGFR in Cancer Research
- Dermatology and Skin Diseases
- Bacteriophages and microbial interactions
- Vector-Borne Animal Diseases
- Pregnancy and Medication Impact
- Cellular transport and secretion
- Escherichia coli research studies
- Hepatitis B Virus Studies
Ministry of Health of the Russian Federation
2017-2024
Gamalei Institute of Epidemiology and Microbiology
2013-2022
Ebola hemorrhagic fever, also known as virus disease or EVD, is one of the most dangerous viral diseases in humans and animals. In this open-label, dose-escalation clinical trial, we assessed safety, side effects, immunogenicity a novel, heterologous prime-boost vaccine against Ebola, which was administered 2 doses to 84 healthy adults both sexes between 18 55 years. The consists live-attenuated recombinant vesicular stomatitis (VSV) adenovirus serotype-5 (Ad5) expressing envelope...
Significance Post-traumatic sterile inflammation is the first necessary step of wound healing. In addition, underlies pathogenesis a multitude common diseases, such as allergies and autoimmune diseases. The molecular mechanisms underlying are still not fully understood. Here, we show that receptor Mincle (Clec4e), expression which highly induced in skin response to damage, recognizes cholesterol sulfate, molecule abundant epidermal layer skin, subsequently inducing pro-inflammatory response....
The mechanisms underlying the complex and multistage wound-healing process are not yet completely understood. One of most important intriguing questions remaining is effect interactions between wounds microflora that present in wounds. In this report, we describe first study treating murine skin with topical bacterial lipopolysaccharide (LPS), main exogenous ligand Toll-like receptor 4. Our findings demonstrate LPS treatment strongly affects by accelerating resolution inflammation,...
Among the non-traditional antibacterial agents in development, only a few targets critical Gram-negative bacteria such as carbapenem-resistant Pseudomonas aeruginosa, Acinetobacter baumannii or cephalosporin-resistant Enterobacteriaceae. Endolysins and their genetically modified versions meet World Health Organization criteria for innovation, have novel mode of action, no known bacterial cross-resistance, are being intensively studied application against pathogens.
Cellular lipid uptake (through endocytosis) is a basic physiological process. Dysregulation of this process underlies the pathogenesis diseases such as atherosclerosis, obesity, diabetes, and cancer. However, to date, only some mechanisms endocytosis have been discovered. Here, we show previously unknown mechanism cargo into cells mediated by receptor Mincle. We found that Mincle, shown be pattern recognition innate immune system, tightly binds range self-lipids. Moreover, revealed minimal...
Influence of topical application bacterial lipopolysaccharide (LPS), a Toll-like receptor 4 agonist, upon epithelization process was investigated, using murine incisional skin wound model. It shown that LPS accelerates epithelization, and this associated with increased levels epidermal growth factor secretion in wounded area.
Bacterial endotoxins (lipopolysaccharides (LPSs)) are important mediators of inflammatory processes induced by Gram-negative microorganisms. LPSs the key inducers septic shock due to a bacterial infection; thus, structure and functions specific interest. Often, highly purified must be isolated from small amounts biological material. Each currently available methods for LPS extraction has certain limitations. Herein, we describe rapid simple microscale method extracting LPSs. The consists...
Tick-borne spotted fevers caused by Rickettsia occur worldwide. The symptoms of this bacterial infection are similar to those viral infection, and thus, diagnostic accuracy has special clinical importance. One the commonly used methods for diagnosis tick-borne fever is enzyme-linked immunosorbent assay (ELISA), which based on estimation presence specific IgM antibodies in blood. However, IgA analysis not been rickettsial diseases thus far. We investigated value antibody determination using...