A5092577047- Human Health and Disease
- Fibroblast Growth Factor Research
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
Ministry of Health of the Russian Federation
2023
To protect young individuals against SARS-CoV-2 infection, we conducted an open-label, prospective, non-randomised dose-escalation Phase 1/2 clinical trial to evaluate the immunogenicity and safety of prime-boost “Sputnik V” vaccine administered at 1/10 1/5 doses adolescents aged 12–17 years. The study began with vaccination older cohort (15-to-17-year-old participants) lower (1/10) dose then expanded whole group (12-to-17-year-old participants). Next, was used according same scheme. Both...
Introduction. COVID-19 is characterized by a varied clinical course.
 The aim of the work was to identify associations SNPs hemostatic system genes with COVID-19.
 Materials and methods. DNA isolated from patients (n=117) healthy participants (n=104). All infected were divided into 3 groups, depending on disease severity assessment, which appreciated NEWS2. Another group consisted participants, who had asymptomatic infection in past. Determination FGB (-455 G/A), FII (20210 FV...