A5056880431- Inflammatory Bowel Disease
- Autoimmune and Inflammatory Disorders
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Pancreatitis Pathology and Treatment
- Chronic Lymphocytic Leukemia Research
- Galectins and Cancer Biology
- Gene expression and cancer classification
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Digestive system and related health
- Microscopic Colitis
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Retinoids in leukemia and cellular processes
- Nerve injury and regeneration
- Rabies epidemiology and control
- Melanoma and MAPK Pathways
- Acute Myeloid Leukemia Research
- Cancer Mechanisms and Therapy
Penn State Milton S. Hershey Medical Center
2020-2025
Pennsylvania State University
2022-2025
Federal Medical-Biological Agency
2014-2020
Ministry of Health of the Russian Federation
2014-2015
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2014
Abstract Background CD4+ T cells contribute to chronic inflammation and fibrosis in inflammatory bowel disease (IBD), but the cellular mechanisms remain elusive. We have found that mitogen-activated protein kinase 2 (MK2) pathway plays a major role overall pathology IBD. Thus, here, we examined of MK2 regulating cell responses IBD models. Methods Interleukin-10 (IL-10) knockout (KO) mice treated with inhibitors (MK2i) CD4-specific knockdown dextran sodium sulfate (DSS) treatments were used...
Previously we demonstrated that the resection of primary 4T1 tumors only slightly prolongs mouse survival, but importantly, creates a "window opportunity" with attenuated suppressor cell and increased activated T populations. This suggests additional activation immune system by immunostimulatory agents during this period may enhance anti-tumor immunity potentially eradicate micro-metastatic disease in stringent model. We hypothesized immunostimulator Immunomax®, which is comprised...
Abstract INTRODUCTION Three novel therapies have shown promise in managing moderate-to-severe ulcerative colitis (UC): fecal microbiota transplantation (FMT), mesenchymal stem cell (MSC) therapy, and targeting the JAK/STAT signaling pathway. Individually, these treatment approaches face issues with either safety concerns or limited efficacy due to disease relapses. Yet, development of better strategies is hampered by knowledge about cellular mechanisms driving chronic inflammation relapse...
Abstract INTRODUCTION The development of Inflammatory Bowel Disease (IBD) involves increases in the inflammatory immune response to dysbiotic gut microbiota genetically-susceptible individuals. Bacterial sensing by Toll-like receptors and downstream MyD88 signaling is critical for maintaining intestinal homeostasis involved pathogenesis inflammation relevant IBD. Mesenchymal stromal cells, particularly fibroblasts, have recently emerged as key regulators macrophages. suggested shape...
Abstract Background Mesenchymal stromal cells are suggested to play a critical role in Crohn’s disease [CD]-associated fibrosis. MAPKAPK2 [MK2] has emerged as potential therapeutic target reduce inflammation CD. However, the cell-specific pattern of phospho-MK2 activation and its CD-associated fibrosis unknown. The objectives this study were evaluate changes MK2 activity between predominantly inflammatory CD vs with fibrotic complications define Methods tissue, tissue-derived mesenchymal...
Agonists of TLR3 and TLR4 are effective immunoadjuvants for different types vaccines. The mechanisms their immunostimulatory action differ significantly; these differences particularly critical immunization with non-replicating adenovirus vectors (rAds) based Unlike traditional vaccines, rAd vaccines not designed to capture vaccine antigens from the external environment by antigen presenting cells (APCs), but rather they targeted de novo synthesis in APCs transfected rAd. To date, there is...
// Romain Villéger 1 , Marina Chulkina 2 Randy C. Mifflin 3 Don W. Powell 4 5 and Irina V. Pinchuk Université de Poitiers, UMR CNRS 7267, Ecologie et Biologie des Interactions, France Department of Medicine at PennState Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA Internal Medicine, Division Gastroenterology Hepatology, UTMB, Galveston, TX 77555, Institute for Translational Sciences, Neuroscience Cell Biology, Correspondence to: Iryna Pinchuk, email:...
In the study, effect of TLR4 agonist Immunomax was investigated in vitro and vivo. particular, shown to polarize mouse bone marrow macrophages from M0 M2 states into M1 state (ARG1 iNOS mRNA expression levels were used identify phenotypes). Next, we prophylactic antiviral both a model respiratory syncytial virus (RSV) infection RSV-induced bronchial asthma (BA) exacerbation. experiment with BA exacerbation, Immunomax-treated mice characterized by significant decrease viral load lung...
Иммуногенные и защитные свойства рекомбинантного аденовируса человека 5-го серотипа, экспрессирующего ген гликопротеина G вируса бешенства вакцинного штамма РВ-971 Федеральное государственное бюджетное учреждение «Национальный исследовательский центр эпидемиологии микробиологии имени почетного академика Н.Ф.Гамалеи» Министерства здравоохранения Российской Федерации