A5056941518- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Hematological disorders and diagnostics
- Mitochondrial Function and Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Coronary Interventions and Diagnostics
- Quality and Safety in Healthcare
- Metabolism and Genetic Disorders
- Metabolism, Diabetes, and Cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Exercise and Physiological Responses
- Cardiovascular and Diving-Related Complications
- Immunotherapy and Immune Responses
- ATP Synthase and ATPases Research
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Cytomegalovirus and herpesvirus research
- Pluripotent Stem Cells Research
- Molecular Biology Techniques and Applications
- Nanoparticle-Based Drug Delivery
Qinghai University Affiliated Hospital
2009-2024
Qinghai University
2015-2022
Liaoning Provincial People's Hospital
2006-2013
Binzhou Medical University
2007
Binzhou University
2007
Abstract Objectives To explore the prevalence and associated factors of obesity in Tibetan adults Qinghai, China, to determine association between FTO (rs1121980 rs17817449) MC4R gene (rs17782313 rs12970134) polymorphisms with obesity. Methods A cross-sectional survey was conducted 2015 Qinghai selected aged 20 80 years. Prevalence (BMI ≥ 28 kg/m 2 ) overweight 24 ~ 27.9 were evaluated. Multivariable logistic models used factors. Pair-matched subjects cases normal-weight controls for...
Abstract Chronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by lifelong exposure to hypoxia. In the present study, proteomic analysis was used identify differentially expressed proteins (DEPs) and then evaluate potential plasma biomarkers between CMS non-CMS groups. A total of 145 DEPs were detected in Han Chinese people who live plateau (CMS-HPu), among which 89 significantly up-regulated 56 down-regulated. GO enrichment showed that various biological processes...
Juan Su, Zhanquan Li, Sen Cui, Linhua Ji, Hui Geng, Kexia Chai, Xiaojing Ma, Zhenzhong Bai, Yingzhong Yang, Tana Wuren, Ri-Li Ge, and Matthew T. Rondina. The local HIF-2α/EPO pathway in the bone marrow is associated with excessive erythrocytosis increase microvessel density chronic mountain sickness. High Alt Med Biol. 16:318–330, 2015.—Aim: Chronic sickness (CMS) characterized by erythrocytosis, angiogenesis may be involved pathogenesis of this disease. niche primary site erythropoiesis...
Excessive erythrocytosis (EE) is a characteristic of chronic mountain sickness (CMS). Currently, the pathogenesis CMS remains unclear. This study was intended to investigate role EPAS1 in proliferation erythroblasts CMS. Changes HIF-1α and EPAS1/HIF-2α bone marrow 21 patients with 14 control subjects residing at same altitudes were determined by RT-qPCR western blotting. We also developed lentiviral vector, Lv-EPAS1/sh-EPAS1, over-express/silence K562 cells. Cells cycle detected flow...
Chronic hypoxia (CH) is characterized by long-term that associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described a variety of human cancers plays an essential role BM degradation. Therefore, this study investigated the hypoxia-mediated rat bone marrow. Eighty pathogen-free Sprague Dawley male rats were randomly divided into four groups (20 per group)-control group, CH group (exposed to hypobaric chamber at...
The objective of this study is to disclose the association polycythemia with lifestyle-related diseases (hypertension, obesity and glucose intolerance) among three ethnicities in Qinghai, China.The subjects were 393 elderly people (247 Han, 97 Tibetan 49 Mongolian) aged 60 years more living Qinghai (3000 m a.s.l.) China. associated factors analyzed subjects. Excessive was defined as hemoglobin concentration over 20 mg/dL.Polycythemia men, hypoxemia, high diastolic blood pressure (DBP)...
BACKGROUND Chronic mountain sickness (CMS) has a higher incidence in the plateau region. The one of its principal characters is excessive erythrocytosis. PI3K-Akt pathway plays an important role process erythropoiesis, and could downregulate apoptosis by regulating apoptosis-related molecules. In this paper, we explored change erythroblasts effect signal on CMS. MATERIAL AND METHODS A total 22 CMS 20 non-CMS participants were involved study. Bone marrow mononuclear cells cultured treated...
Background: Although there are several factors which may contribute to oxidative stress at high altitude, little is known about the association between and aging in community‐dwelling elderly Tibetan Plateau. Methods: Reactive oxygen species (ROS) comprehensive geriatric functions were examined among 235 subjects aged 60 years or more (146 Hans 89 Tibetans). As a marker of ROS, levels reactive metabolites (ROM) measured using d‐ROM test. Results: The rate dependence basic activities daily...
Objective: To investigate the expression and interaction of VHL/HIF-α pathways including HIF-1α, HIF-2α as well VHL in erythroid progenitor cells bone marrow from chronic mountain sickness (CMS) patients. Methods: A total 25 patients with CMS 21 healthy controls were recruited for this study. The CD71(+)CD235a(+) mononuclear cells, marked isolated using MACS separation technology. levels detected by Western blotting real-time fluorescence quantitative PCR. Results: mRNA higher than [1.68...