A5073822570- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Sleep and related disorders
- Psychological and Temporal Perspectives Research
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Adolescent and Pediatric Healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Treatment of Major Depression
- Eating Disorders and Behaviors
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Health disparities and outcomes
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Anesthesia and Sedative Agents
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Mental Health and Psychiatry
- Migraine and Headache Studies
- Digital Mental Health Interventions
- Youth Substance Use and School Attendance
VA San Diego Healthcare System
2022-2023
University of California, San Diego
2022-2023
Temple University
2016-2022
Temple College
2016-2022
UC San Diego Health System
2021
University of California, Davis
2019-2020
Substance use and addiction are prominent global health concerns associated with abnormalities in reward sensitivity. Reward sensitivity approach motivation supported by a fronto-striatal neural circuit including the orbitofrontal cortex (OFC), ventral striatum (VS), dorsal (DS). Although research highlights circuitry among individuals problematic substance use, questions remain about whether such arises from excessively high, or low, This study examined reward-related brain function...
Sleep disturbances are a key feature of bipolar disorder (BD), and poor sleep has been linked to mood symptoms. Recent use ecological momentary assessment (EMA) allowed for nuanced exploration the sleep-mood link; though, scale directionality this relationship is still unclear. Using EMA, actigraphy, self-reported measures, study examines concurrent predictive relationships between mood. Participants with BD (n = 56) wore actigraphy devices up 14 days completed validated scales daily EMA...
The role of activation in the pathogenesis bipolar spectrum disorders (BSD) is growing interest. Physical activity known to improve mood, but it unclear whether low levels contribute inter-episode depressive symptoms observed BSD. This study examined sedentary and vigorous activity, as well timing were differentially associated with next-day for individuals at risk BSD, high-risk diagnosed BSD.Young adults (n = 111, ages 18-27) from three groups (low BSD risk, high diagnosis), participated a...
Abstract There is a need to better understand key factors that impact sleep and circadian function for young adults of differing races sexes. Sex race are common contributing disparities in health outcomes; however, the influence these variables on patterns not well known. Multiple objective self-report facets were assessed (melatonin onset, actigraphy, diaries) an ecological momentary assessment study 150 emerging ( M age = 21.8 years; 58.7% female; 56% White, 22.7% Black, 21.3% Other...
Abstract Objective Elevated sensitivity to rewards prospectively predicts Bipolar Spectrum Disorder (BSD) onset; however, it is unclear whether volumetric abnormalities also reflect BSD risk. BSDs emerge when critical neurodevelopment in frontal and striatal regions occurs sex‐specific ways. The current paper examined the volume of brain both individuals with at risk for a exploratory analyses examining sex‐specificity. Methods One hundred fourteen medication‐free ages 18–27 low‐risk...
Abstract Aim The trauma‐psychosis cycle proposes an interactive relationship between impaired developmental and cognitive trajectory, childhood trauma exposure, increased risk for psychosis. This study explored how (CT) atypical development (AD) impact clinical course in early psychosis cohort. Methods A retrospective chart review of behavioural research data was conducted with individuals ages 12 to 40 (N = 508; 72.4% males) evaluated by program. Results CT exposure associated earlier onset...
Abstract Amygdala abnormalities are widely documented in bipolar spectrum disorders (BSD). volume typically is measured after BSD onset; thus, it not known whether amygdala predict risk or relate to the disorder. Additionally, past literature often treated as a homogeneous structure, and did consider its distinct subnuclei their differential connectivity other brain regions. To address these issues, we used behavioral high‐risk design diffusion‐based subsegmentation examine among...
Bipolar spectrum disorders (BSDs) are associated with reward hypersensitivity, impulsivity, and structural abnormalities within the brain's system. Using a behavioral high-risk study design based on sensitivity, this paper had two primary objectives: 1) investigate whether elevated positive urgency, tendency to act rashly when experiencing extreme affect, is risk for or correlate of BSDs, 2) examine nature relationship between urgency grey matter volume in fronto-striatal regions, among...
Abstract Objectives: Persons with schizophrenia, schizoaffective, or bipolar I disorder are more likely to die by suicide compared the general population. Dysfunctional attitudes have been shown be significant predictors of cognitive vulnerability depression, hopelessness, and poor problem‐solving skills, which predict suicidal ideation. common in persons schizophrenia spectrum disorders (SSDs) I. The Reasons for Living Inventory (RFLI) examines distinct reasons not dying suicide. This...
Abstract Background Impulsivity is a prominent feature of bipolar disorder associated with various negative sequelae; moreover, it may be precursor to shifts in affect or mood, but little known about its association on day-to-day timescale. Ecological momentary assessments (a method that captures moment-to-moment ratings psychological states by repeatedly sampling the same individual) impulsivity and using mobile surveys allow for more nuanced examination mechanisms mood behavior...
Intranasal administration of esketamine is Food and Drug Administration-approved for treatment-resistant depression. In a recent retrospective case series, we show that it has promise in reducing symptoms posttraumatic stress disorder (PTSD) as well. Untreated obstructive sleep apnea (OSA) prevalent among veterans with PTSD been shown to interfere other treatments. the current study, examined whether OSA impacts esketamine's effectiveness or
Adolescence/early adulthood is an “age of risk” for bipolar spectrum disorders (BSDs). BPDs have been linked to circadian rhythm and reward processing disruptions; such disruptions may serve as risk factors BSD mood symptoms/ However, the bidirectional relationships systems not systematically examined in or at-risk individuals. 150 adults (ages 18–27; mean age ± SD, 21.9 2.1y; 88 women), with high sensitivity a (n = 43), but no 64), low-risk individuals moderate 43) participated 20-day...
Abstract Insomnia contributes to individual mental and physical health relationship well‐being. Veterans' PTSD symptoms are associated with their own insomnia. However, research has not explored whether how veterans' partners' The present study examined the association between symptom severity Veterans ( n = 192) partners 192; total N 384) completed baseline assessments in a treatment for veterans partners. Path analysis was used examine relation severity, as measured by checklist‐5 (PCL‐5)...