A5103137805- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Hepatitis C virus research
- Bipolar Disorder and Treatment
- Cardiac Imaging and Diagnostics
- Electronic Health Records Systems
- Patient Safety and Medication Errors
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- HIV-related health complications and treatments
- Healthcare Technology and Patient Monitoring
- Sports injuries and prevention
- Cardiac Structural Anomalies and Repair
- Hepatitis B Virus Studies
- Pharmaceutical Practices and Patient Outcomes
- Sleep and related disorders
- Restraint-Related Deaths
- Psychosomatic Disorders and Their Treatments
- Cardiac electrophysiology and arrhythmias
- Neonatal Health and Biochemistry
- Drug Solubulity and Delivery Systems
GlaxoSmithKline (United States)
2004-2022
Age UK
2022
University of Illinois Urbana-Champaign
2017-2021
Triangle
2021
Human BioMolecular Research Institute
2021
Illinois College
2020-2021
Research Triangle Park Foundation
2000-2020
Carle Foundation Hospital
2020
Horizon Therapeutics (United States)
2018
University of Wisconsin–Madison
2011-2013
The majority of prosthetic heart valves currently implanted are tissue that can be expected to degenerate with time and eventually fail. Repeat cardiac surgery replace these is associated significant morbidity mortality. Transcatheter valve implantation within a failed bioprosthesis, "valve-in-valve" procedure, may offer less invasive alternative.Valve-in-valve implantations were performed in 24 high-risk patients. Failed aortic (n=10), mitral (n=7), pulmonary (n=6), or tricuspid (n=1)...
We have analyzed the molecular dynamics of emergence drug-resistant strains in patients receiving lamivudine therapy for chronic hepatitis B. Twenty consecutive with resistance were studied (13 B e antigen [HBeAg]-positive and 7 HBe antibody [anti-HBe]-positive patients). Determination viral genotype, precore mutants, polymerase gene mutants (L528M, M552V, M552I) was performed using research version Lipa-HBV. Quantitative analysis HBV DNA both branched (bDNA) chain reaction (PCR) assays....
To evaluate the incidence of duplicate medication orders before and after computerized provider order entry (CPOE) with clinical decision support (CDS) implementation identify contributing factors.CPOE alerts was implemented in a 400-bed Northeastern US community tertiary care teaching hospital. In pre-implementation post-implementation design, trained nurses used chart review, computer-generated reports orders, alerts, staff to errors two intensive units (ICUs).Medication error data were...
Objective To examine medication safety in two intensive care units (ICU), and to assess the complexity of errors adverse drug events (ADE) ICUs across stages medication-management process. Methods Four trained nurse data collectors gathered on ADEs between October 2006 March 2007. Patient documents (eg, order sheets, notes) incident reports were used identify a 24-bed adult medical/surgical ICU an 18-bed cardiac tertiary care, community teaching hospital. In this cross-sectional study, total...
Abstract Numerous studies of sodium‐lithium countertransport (Na‐Li CNT) have reported higher rates in essential hypertensives versus normotensive controls. We studied the distribution and mode inheritance Na‐Li CNT using a sample 238 unrelated individuals 245 50 pedigrees all sampled from population at large. The is continuous bimodal. Our results indicate that there large genetic contribution to CNT. hypothesis effect causes bimodality transmitted generation supported by fit these data...
Dolutegravir (DTG), an unboosted HIV integrase inhibitor (INI), is metabolized by UGT1A1 and to a minor extent CYP3A. Renal elimination of unchanged DTG very low (< 1 %). As renal impairment may affect pharmacokinetics (PK), even for drugs primarily or secreted in bile, this study investigated the effect on PK DTG.This was open-label, single-dose oral 50 mg administered subjects with severe (creatinine clearance [CLcr] <30 mL/min; not dialysis) healthy controls (CLcr >90 mL/min) matched...
Studies finding an increased maximal rate of Na-Li countertransport in red blood cells from persons with essential hypertension and their normotensive offspring have raised the possibility that may serve as a marker for genetic predisposition to hypertension. We studied 238 randomly selected donors representative population Rochester, Minnesota. The mean value (+/- SD) units mmoles lithium efflux per liter hour was 0.29 +/- 0.12. distribution values among continuous. An analysis...
The objective of this study was to describe the frequency, potential harm, and nature electronic health record (EHR)-related medication errors in intensive care units (ICUs). Using a secondary data analysis large database safety events collected on EHR technology ICUs, we assessed relatedness total 1622 preventable adverse drug (ADEs) identified sample 624 patients 2 ICUs medical center. Thirty-four percent were found be related. EHR-related had greater for more serious patient harm occurred...
A phase I, repeat‐dose, open‐label study was conducted to determine the pharmacokinetics and safety of zidovudine lamivudine, coadministered orally every 12 hours, in 16 neonates whose mothers were infected with human immunodeficiency virus type 1 (HIV‐1). The prospective had been stabilized on a zidovudine/lamivudine regimen since week 36 pregnancy prevent mother‐to‐child transmission HIV During postpartum, received 300 mg plus lamivudine 150 hours breastfed. Neonatal treatment initiated...
The purpose of this study was to investigate the pharmacokinetics a single oral dose lamivudine administered subjects with renal impairment and determine whether dialysable in severe undergoing haemodialysis.Twenty-nine were enrolled, nine normal function (creatinine clearance (CL(CR)) 82-117 ml min(-1)), eight moderately impaired (CL(CR) 25-49 six 13-19 min(-1)) who also receiving haemodialysis. After an overnight fast, nondialysis received lamivudine. Subjects on haemodialysis given two...
Background: Cancelled shock therapy (CxTx) may presage delivery and shorten battery longevity of implantable cardioverter‐defibrillators (ICDs). However, it is silent has received little attention. Remote home monitoring (HM) with continuous surveillance automatic daily data archiving allows investigation CxTx. Methods Results: We retrospectively analyzed a database 4,960 recipients HM ICD, from 2002 to 2007. Over mean follow‐up 445 ± 253 days, CxTx occurred in 1,392 (28%) patients, mostly...
Objective The aim of the study was to assess impact Electronic Health Record (EHR) implementation on medication safety in two intensive care units (ICUs). Methods Using a prospective pre-post design, we assessed 1254 consecutive admissions ICUs before and after an EHR implementation. Each event evaluated with regard error (error type, medication-management stage) patient (severity potential or actual harm). Results We identified 4063 medication-related events either pre-implementation (2074...
GSK2838232 is a second-generation, potent, small-molecule, oral human immunodeficiency virus type 1 (HIV-1) maturation inhibitor for once-daily administration boosted with pharmacoenhancer.The phase 2a, proof-of-concept study was an open-label, adaptive dose-ranging design. Safety, pharmacokinetics, and efficacy of by cobicistat were evaluated in individuals HIV-1 infection. The participants (N = 33) received once daily across range doses (20-200 mg) 150 mg 10 days.GSK2838232 safe well...
Aims The aim was to evaluate the effect of boceprevir and telaprevir on dolutegravir pharmacokinetics ( PK ); assessed through comparison with historical data for each hepatitis C virus HCV ) drug's prescribing information alone. Methods This a single‐centre, randomized, open‐label, two‐cohort, two‐period, one‐way study in healthy adult subjects. Dolutegravir 50 mg once daily administered 5 days Period 1, coadministered either 800 every 8 h (Cohort 1) or 750 2) 10 2. Results N o deaths...
<h3>Objective</h3> We investigated the contribution of small vessel disease (SVD) to anticoagulant-associated intracerebral haemorrhage (ICH). <h3>Methods</h3> Clinical Relevance Microbleeds in Stroke-2 comprised two independent multicentre observation studies: first, a cross-sectional study patients with ICH; and second, prospective taking anticoagulants for atrial fibrillation (AF) after cerebral ischaemia. In ICH, we compared SVD markers on CT MRI according prior anticoagulant therapy. AF...
Abstract This work aimed to assess the safety, tolerability, pharmacokinetics ( PK ), and relative bioavailability of GSK 2838232, an investigational HIV maturation inhibitor. 2838232 was administered over four dose‐escalation studies in healthy subjects which assessed single oral doses (5‐250 mg) repeat (up 200 mg once or twice daily) ±100 ritonavir RTV ) daily. administration 250 124 across resulted few mild adverse events AE s) with similar frequencies placebo. There were no clearly...