A5062588685- Retinal Diseases and Treatments
- Bioactive Compounds and Antitumor Agents
- Mosquito-borne diseases and control
- Retinal and Optic Conditions
- Hedgehog Signaling Pathway Studies
- Ion Channels and Receptors
- Glaucoma and retinal disorders
- interferon and immune responses
- Genomics, phytochemicals, and oxidative stress
- Complement system in diseases
- Retinal Imaging and Analysis
- Cancer Treatment and Pharmacology
- Ocular Diseases and Behçet’s Syndrome
- Ocular Oncology and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Estrogen and related hormone effects
- Calcium signaling and nucleotide metabolism
Universitätsmedizin Göttingen
2023
Queen's University Belfast
2018-2022
Abstract Background Macular fibrosis causes irreparable vision loss in neovascular age-related macular degeneration (nAMD) even with anti-vascular endothelial growth factor (VEGF) therapy. Inflammation is known to play an important role although the underlying mechanism remains poorly defined. The aim of this study was understand how infiltrating macrophages and complement proteins may contribute fibrosis. Methods Subretinal induced C57BL/6J mice using two-stage laser protocol developed by...
T cell activation starts with formation of second messengers that release Ca2+ from the endoplasmic reticulum (ER) and thereby activate store-operated entry (SOCE), one essential signals for activation. Recently, steroidal 2-methoxyestradiol was shown to inhibit nuclear translocation factor activated cells (NFAT). We therefore investigated inhibition in cells, screened a library analogues, characterized derivative 2-ethyl-3-sulfamoyloxy-17β-cyanomethylestra-1,3,5(10)-triene (STX564) as...
Aging-associated chronic oxidative stress and inflammation are known to be involved in various diseases, e.g., age-related macular degeneration (AMD). Previously, we reported the presence of dry AMD-like signs, such as elevated stress, dysfunctional mitophagy accumulation detrimental oxidized materials retinal pigment epithelial (RPE) cells nuclear factor erythroid 2-related 2, a peroxisome proliferator-activated receptor gamma coactivator 1-alpha (NFE2L2/PGC1α) double knockout (dKO) mouse...
Abstract Uncontrolled inflammation in the retina can lead to fibrovascular membrane formation, which cause severe structural damage thus leading blindness. The pathogenesis of retinal fibrosis is not completely understood. Recent research has implicated Hedgehog pathway transcription factor Gli1 development fibrosis. This study aims elucidate role membranes utilising fluorescent reporter mice. Gli1CreERT 2 mice were crossed with ROSA26TdTomato produce Tomato x crossbreeds. 6‐7 week old...
Abstract Purpose Aging‐associated chronic oxidative stress and inflammation are known to be involved in various diseases, e.g. age‐related macular degeneration (AMD). Previously, we reported elevated stress, dysfunctional mitophagy the accumulation of detrimental oxidized materials pigment epithelial (RPE) cells dry AMD‐like nuclear factor erythroid 2‐related 2, peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha ( NFE2L2/PGC1α ) a double knockout (dKO) mouse model. In this...