There is a great need to make rapid differential clinical diagnosis of COVID-19 among respiratory disease patients and determining the prevalence rate these diseases population.Approximately 522 with allergic rhinitis, asthma, COPD, were analysed for demographic features. Radiological features only patients.COPD asthma more common than rhinitis. All chest CT scans showed bilateral ground-glass opacity. Fever, dry cough, diarrhea, loss sense smell taste, shortness breath, blue lips...

Background and Objectives: Vitamin D supplementation plays a key effect in lowering cytokine storms among COVID-19 patients by influencing the activity of renin-angiotensin system production angiotensin-2 converting enzyme. The study was conducted to explore high-dose intramuscular vitamin hospitalized adults infected with moderate-to-severe SARS-CoV-2 comparison standard care protocol. Materials Methods: Two groups were compared this prospective randomized controlled trial as administered...

The effectiveness of the best combination between different antiviral and anti-inflammatory drugs stills an interest in treatment COVID19 infection.A prospective randomized cohort study comprised 108 adult patients with confirmed PCR COVID 19 infection systemic hyper inflammation state, divided into two groups according to regimen, 56 tocilizumab- hydroxychloroquine (TCZ-HCQ) treatment, 52 tocilizumab-remdesivir (TCZ-RMV) treatment. first group received a I.V. TCZ (400-800 mg every 24 h for...

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have emerged as promising therapeutics for heart failure (HF). Nevertheless, evidence supporting the mechanism of SGLT2i efficacy in HF patients is currently limited. Genetic variation SLC5A2 (encoding SGLT2) may influence progression and response, well inform potential mechanisms. Thus, this study investigated associations between clinical outcomes SGLT2i-naïve dapagliflozin-treated cohorts. We analyzed two cohorts to identify variants...

Awareness about the COVID-19 vaccine's adverse effects is crucial for gaining public trust. As we still lack proof of vaccines' safety, this survey aimed to investigate Egyptians' general awareness Sinopharm and AstraZeneca vaccines against provide considerable evidence on their side complications.A cross-sectional questionnaire-based study was conducted in Egypt between 20 September 10 October 2021, with multiple-choice questions (MCQs) covering all data vaccine administration confusion, or...

<h3>BACKGROUND:</h3> A new holding chamber was designed to be used with the Aerogen Solo nebulizer increase aerosol emitted that reach patient. The aim of this study evaluate efficacy and determine its usability other nebulizers. <h3>METHODS:</h3> divided into 2 parts. In first part, 1 mL respirable solution (nominal dose 5000 μg salbutamol), delivered by using mesh nebulizer, Pro jet connected a T-piece or chamber, determined breathing simulator set provide tidal volume 500 mL, frequency 15...

The treatment of severe cases COVID-19 disease remains a dilemma so far, because there is no approved therapy for it. This study aimed to estimate the therapeutic efficacy tocilizumab and its role in reducing need mechanical ventilation, length hospital stay, mortality rate these cases.The included 25 adult patients with confirmed infection. Treatment all followed Egyptian Ministry Health protocol addition IV (400-800 mg) as single dose then was repeated after at least 12 hours up 24 from...

Severe stages of COVID-19 infection have been associated with the excessive discharge pro-inflammatory mediators such as cytokines, resulting in lung deterioration, which progresses rapidly to fibrosis leading acute respiratory distress syndrome. In this investigation, efficacy and safety novel antifibrotic anti-inflammatory agent, Pirfenidone, were assessed patients pulmonary secondary cytokine storm. randomized controlled study, we assigned 100 adult storm admitted intensive care isolation...

This study was intended to explore sociodemographic, nutritional, and health-related factors on the incidence of COVID-19 infection within Egyptian population by assessing frequency determinants post-COVID-19 symptoms complications. A cross-sectional using a structured survey 15,166 participants adopted. The results revealed common including fever (79.1%), cough (74.5%), anosmia&amp; ageusia (68.4%), dyspnea (66.9%). patients were nonsmokers (83.9%), while 9.7% mild smokers. percentage...

High variability of linezolid blood concentrations with partial subtherapeutic levels was observed in critically ill patients who received a standard intravenous dose linezolid, contributing to drug resistance and toxicity. Continuous infusions have been suggested as an alternative provide good serum alveolar without fluctuations trough concentration. This study aimed assess the effectiveness safety continuous infusion versus regimen patients. A prospective randomized controlled conducted on...

COVID-19 is a fatal, fast-spreading pandemic, and numerous attempts are being made around the world to understand manage disease. patients may develop cytokine-release syndrome, which causes serious respiratory diseases and, in many cases, death. The study examined feasibility of employing legally available anti-inflammatory pentoxifylline (PTX), low toxicity cost medication, mitigate hyper-inflammation caused by COVID-19. Thirty adult who tested positive for SARS-CoV2 were hospitalized...

<h3>BACKGROUND:</h3> A new holding chamber was designed to be used with a vibrating mesh nebulizer increase the total inhalable dose for patients. It facilitates intermittent and continuous nebulization as well optional supply of supplemental oxygen via T-piece mouthpiece adapter. This study aimed evaluate effect introduction in on aerosol delivery using nebulizer. <h3>METHODS:</h3> The divided into 2 parts. First, 1 mL respirable solution (nominal 5,000 μg-salbutamol) determined breathing...

Abstract The objective of this study was to assess the use pMDI alone and with different spacers in asthmatic patients identify any associations between errors handling device for first time sessions needed reach correct method, considering patient demographics clinical characteristics. A total 150 Asthmatic were crossed over handle add-on inhalable devices (Aerochamber plus, Tips Haler, Able, Dispozable Aer-8) randomly, without receiving verbal or demonstrative instruction (baseline...

Introduction Aerosol delivery from DPIs could be affected by different factors. This study aimed to evaluate and predict the effects of factors on drug DPIs. Methods Modelling optimisation for both in vitro vivo data (Diskus, Turbohaler Aerolizer) were carried out using neural networks associated with genetic algorithms results are confirmed a decision tree (DT) random forest regressor (RFR). All variables (the type DPI, inhalation flow, volume, number inhalations subject) coded as numbers...

Background: This study aimed to evaluate the Egyptian population’s preference and awareness related available COVID-19 vaccines determine different factors that can affect beliefs concerning these vaccines. Methods: A cross-sectional web-based was carried out among general population in Egypt. Data collection conducted via an online questionnaire. Results: About 426 subjects participated survey. Vaccine is nearly equally even (50%) all respondents. There no significant difference vaccine...

Uterine blood flow determines endometrial thickness. This study examined how vaginal sildenafil citrate and estradiol valerate altered thickness, flow, fertility in infertile women. observed 148 women whose infertility was unexplained. Group 1 comprised 48 patients who received oral (Cyclo-Progynova 2 mg/12 h white tablets) from day 6 till ovulation initiated with clomiphene citrate. A number of 50 participants group (Respatio 20 film-coated for 5 days starting the after their previous...

Abstract Backgrounds Although metered‐dose inhalers (pMDI) therapy is convenient and widely prescribed, its use usually results in repetitive inhalation technique errors. One of the most errors inhaling too fast through pMDI. The present study aimed to evaluate effect Clip‐tone ® along with smartphone visual feedback application on subject's time. Methods Two hundred subjects were included study. They randomised into four groups. Group 1 received only verbal counselling; group 2 counselling...

Background and Objectives: Inappropriate antibiotic usage in hospitalized patients contributes to microbial resistance. Our study aimed examine the incidence of clinical bacterial isolates their resistance burden among critically ill different hospital units. Materials Methods: A single-centered cross-sectional was conducted a 120-bed tertiary care that included 221 with hospital-acquired infections. Bacterial cultures sensitivity reports were obtained followed by formal analysis antibiogram...

Background: Several techniques had been developed to generate aerosolized medications during noninvasive ventilation (NIV) using variable inhalation methods. This study hypothesized that large spacers were more efficient significantly than small and adapters NIV. Objective: The main objective of this was compare the performance newly with standard T-piece in NIV chronic obstructive pulmonary disease (COPD) subjects. Methods: Sixty COPD subjects requiring included study. A dual-limb circuit...

Asthma is a prevalent condition, and significant number of individuals with asthma are often misdiagnosed other diseases. Inhalation therapy, pressurized metered-dose inhaler (pMDI), the most used treatment for asthma. Spacers valved holding chambers (VHCs) supplementary devices (pMDIs), specifically created to address typical difficulties patients encounter while using pMDI give aerosol medication. were designed problems that have method, such as coordinating actuation inhalation, well...

<b>Background:</b> While pMDI are extensively prescribed, its use frequently results in repetitive inhalation-techniques mistakes. One of the most errors is inhaling too fast through pMDI. <b>Aims and Objectives:</b> The aim present study was to assess effect Clip-tone® with linked smartphone application on inhalation-flow subjects. <b>Methods:</b> 200 subjects were involved study. They randomized into 4 groups. Group 1 received only verbal counseling; group 2 counseling plus resistance (a...

Background: Although it was initially believed that the coronavirus disease 2019 (COVID-19) only attacked respiratory system, reports over time demonstrated this could attack gastrointestinal tract (GIT) as well. The predominant presenting symptoms in patients infected with COVID-19 were gastrointestinal, resulting (GI) pathological changes. While clinicians’ concerns are mostly related to system manifestations, GI should be monitored and managed appropriately. Objectives: This review...

Abstract Background A holding chamber (HC) was created to work with a vibrating mesh nebulizer (VMN) boost the total inhalable dose for patients. In addition optional supply of supplemental oxygen, it facilitates intermittent and continuous nebulization. Our goal see how well VMN coupled HC mouthpiece or valved facemask performed at varied oxygen flows starting 0–6 L/min. this study, we used breathing simulator simulate adults' spontaneous patterns tidal volume 500 mL 1:1...

Background: The treatment of COVID-19 disease remains a dilemma so far because there is no approved therapy for it. This study aimed to evaluate the use hydroxychloroquine and azithromycin combination in treatment. Objective: was carried out determine safety effectiveness COVID 19 patients. Methods: included 90 adult Treatment all patients followed Egyptian Ministry Health protocols, receiving 400mg twice on day 1, then 200 mg daily addition 500mg/day 5 days. ECG findings, especially QTc...