A5046167946- Pharmacovigilance and Adverse Drug Reactions
- Artificial Intelligence in Healthcare and Education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Machine Learning in Healthcare
- Pharmaceutical studies and practices
- Drug-Induced Adverse Reactions
- Meta-analysis and systematic reviews
- Patient Safety and Medication Errors
- Respiratory Support and Mechanisms
- Academic integrity and plagiarism
- Ethics in Clinical Research
- Pharmaceutical Practices and Patient Outcomes
- Asthma and respiratory diseases
- Health, Environment, Cognitive Aging
- Emergency and Acute Care Studies
- Topic Modeling
- Nutritional Studies and Diet
- Respiratory viral infections research
- Respiratory and Cough-Related Research
- Clostridium difficile and Clostridium perfringens research
- Health Policy Implementation Science
- Pharmacy and Medical Practices
- Food Allergy and Anaphylaxis Research
Erasmus MC
2022-2024
University of Groningen
2022
Abstract Objective Observational studies can impact patient care but must be robust and reproducible. Nonreproducibility is primarily caused by unclear reporting of design choices analytic procedures. This study aimed to: (1) assess how the logic described in an observational could interpreted independent researchers (2) quantify interpretations’ variability on characteristics. Materials Methods Nine teams highly qualified reproduced a cohort from Albogami et al. The were provided clinical...
Introduction: Monoclonal antibodies (mAbs) targeting immunoglobulin E (IgE) [omalizumab], type 2 (T2) cytokine interleukin (IL) 5 [mepolizumab, reslizumab], IL-4 Receptor (R) α [dupilumab], and IL-5R [benralizumab]), improve quality of life in patients with T2-driven inflammatory diseases. However, there is a concern for an increased risk helminth infections. The aim was to explore safety signals parasitic infections omalizumab, mepolizumab, reslizumab, dupilumab, benralizumab. Methods:...
While medication errors (MEs) have been studied in the European Medicines Agency's EudraVigilance, extensive characterisation and signal detection based on sexes age groups not attempted.
Abstract Background Medication errors (MEs) are a major public health concern which can cause harm and financial burden within the healthcare system. Characterizing MEs is crucial to develop strategies mitigate in future. Objectives To characterize ME‐associated reports, investigate signals of disproportionate reporting (SDRs) on Food Drug Administration's Adverse Event Reporting System (FAERS). Methods FAERS data from 2004 2020 was used. ME reports were identified with narrow Standardised...
<b>Background:</b> Azithromycin (AZM) has shown in randomized clinical trials (RCTs) to reduce exacerbations individuals with major chronic airway diseases. However, little is known about the trends AZM use real life. <b>Aim:</b> Investigate prescribing among asthma, obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) Integrated Primary Care Information (IPCI) database, a Dutch general practitioner database. <b>Methods:</b> Study period was from 2012-2021. Inclusion criteria...
<b><i>Background:</i></b> Although antibiotic treatment is recommended for acute exacerbations of chronic obstructive pulmonary disease (AECOPD), its value in real-world settings still controversial. <b><i>Objectives:</i></b> This study aimed to evaluate the short- and long-term effects on AECOPD outpatients. <b><i>Methods:</i></b> A cohort was conducted under PharmLines Initiative. We included participants with a first...
<b>Background:</b> Use of respiratory drugs, especially inhalators, is prone to medication errors (MEs) which lead or might patient harm. Limited studies have been conducted on the frequency MEs using spontaneous reporting systems. <b>Aim:</b> Investigate signals disproportionate (SDRs) among drugs (MERs) in Food and Drug Administration's Adverse Event Reporting System (FAERS). <b>Methods:</b> FAERS-report data from 2004-2020 was used. All MERs were selected having Anatomical...