A5001230404- Nuclear Structure and Function
- Microbial Natural Products and Biosynthesis
- Radiopharmaceutical Chemistry and Applications
- Genomics and Phylogenetic Studies
- Plant-Microbe Interactions and Immunity
- Glaucoma and retinal disorders
- ATP Synthase and ATPases Research
- RNA and protein synthesis mechanisms
- Fungal Biology and Applications
- Periodontal Regeneration and Treatments
- Connective Tissue Growth Factor Research
- Plant and Biological Electrophysiology Studies
- Botanical Research and Applications
- Ocular Infections and Treatments
- Cancer Treatment and Pharmacology
- Protease and Inhibitor Mechanisms
- Advanced Chemical Sensor Technologies
- Environmental Toxicology and Ecotoxicology
- Plant biochemistry and biosynthesis
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Plant Disease Resistance and Genetics
- Indoor Air Quality and Microbial Exposure
- Mycotoxins in Agriculture and Food
- Cell death mechanisms and regulation
University of Nottingham
2024
University of the West of Scotland
2018
Institute of Ophthalmology
1991
Science Oxford
1974-1977
The export protein CRM1 is required for the nuclear of a wide variety cancer-related "cargo" proteins including p53, c-Abl, and FOXO-3A. Leptomycin B (LMB) highly specific inhibitor with significant in vitro potency but limited vivo efficacy due to toxicity. We now report series semisynthetic LMB derivatives showing substantially improved therapeutic windows. Exposure cancer cells these compounds leads rapid prolonged block apoptosis. In contrast what observed cells, agents induce cell cycle...
The epothilones, originally isolated from the myxobacterium Sorangium cellulosum, are macrocyclic compounds that synthesized by a modular polyketide synthase, an enzyme complex composed of six large, multifunctional proteins. penultimate intermediates in epothilone production, and products PKS-catalyzed reactions, epothilones D C, which contain 12,13-cis-double bond. 12 13 positions generated during fourth elongation step is governed module 4. Module 4 does not dehydratase (DH) domain,...
Chalcomycin, a 16-membered macrolide antibiotic made by the bacterium Streptomyces bikiniensis, contains 2,3-trans double bond and neutral sugar D-chalcose in place of amino mycaminose found most other macrolides. Degenerate polyketide synthase (PKS)-specific primers were used to amplify DNA fragments from S. bikiniensis with very high identity unique ketosynthase domain tylosin PKS. The resulting amplimers identify two overlapping cosmids encompassing chm Sequencing revealed contiguous...
Abstract The 3D architecture of RNAs governs their molecular interactions, chemical reactions, and biological functions. However, a large number protein complexes remain poorly understood due to the limitations conventional structural biology techniques in deciphering complex structures dynamic interactions. To address this limitation, we have benchmarked an integrated approach that combines cryogenic OrbiSIMS, state-of-the-art solid-state mass spectrometry technique, with computational...
The effects of different doses beta radiation from a strontium-90 source on the proliferation human Tenon9s capsule fibroblasts were studied. cultured exposed to 100, 250, 500, 750, 1000, 1500, and 3000 rads, cell numbers counted at days 3, 7, 14. Treatment inhibited fibroblasts. At seven cells rads showed decrease relative starting numbers, 14 1500 in numbers. which more than 50% (at day 7 14) yet did not cause population 1000 rads. Radiation reduces fibroblasts, higher this effect may be...
Branched-chain amino acids (BCAA) are used as nutritional support for patients with a range of conditions including liver cirrhosis and in-born errors acid metabolism, they commonly “sports” or exercise supplements. The effects the BCAA on in-vitro activity calf intestinal alkaline phosphatase (EC. 3.1.3.1) were studied. All three found to be uncompetitive inhibitors enzyme L-leucine being most potent ([Formula: see text] = 24.9 mmol/L) L-valine, least 37 mmol/L). Mixed able act in...
SUMMARY The resistance of Cunninghamella echinulata to the systemic fungicides fuberidazole (FEZ) and thiabendazole (TBZ), that Penicillium digitatum TBZ, may be due active secretion from hyphae. There was no clear evidence FEZ cause in P. digitatum. Both uptake release FBZ TBZ by potato slices appeared passive processes.
Introduction Fibrosis is a component of many tissue pathologies leading to loss normal function, primarily due excessive collagen deposition. Collagen deposited following cleavage the C‐ and N‐ terminal peptides from pro‐collagen molecule. The globular C‐peptide by PCP reduces solubility fibrillar molecule, resulting in deposition insoluble collagen. Increased feature all organ fibroses, with inhibition this process, key potential anti‐fibrotic mechanism. aim work was discover potent...
Supplementary Figure 1 from Identification of Nuclear Export Inhibitors with Potent Anticancer Activity <i>In vivo</i>
Supplementary Figure 3 from Identification of Nuclear Export Inhibitors with Potent Anticancer Activity <i>In vivo</i>
Supplementary Methods and Materials from Identification of Nuclear Export Inhibitors with Potent Anticancer Activity <i>In vivo</i>
Supplementary Figure 2 from Identification of Nuclear Export Inhibitors with Potent Anticancer Activity <i>In vivo</i>
Supplementary Figure 3 from Identification of Nuclear Export Inhibitors with Potent Anticancer Activity <i>In vivo</i>
Supplementary Figure 1 from Identification of Nuclear Export Inhibitors with Potent Anticancer Activity <i>In vivo</i>
Supplementary Methods and Materials from Identification of Nuclear Export Inhibitors with Potent Anticancer Activity <i>In vivo</i>
Supplementary Figure 2 from Identification of Nuclear Export Inhibitors with Potent Anticancer Activity <i>In vivo</i>
<div>Abstract<p>The export protein CRM1 is required for the nuclear of a wide variety cancer-related “cargo” proteins including p53, c-Abl, and FOXO-3A. Leptomycin B (LMB) highly specific inhibitor with significant <i>in vitro</i> potency but limited vivo</i> efficacy due to toxicity. We now report series semisynthetic LMB derivatives showing substantially improved therapeutic windows. Exposure cancer cells these compounds leads rapid prolonged block apoptosis....