A5070790157- Animal Virus Infections Studies
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Animal Behavior and Welfare Studies
- Viral Infections and Vectors
- Insect and Pesticide Research
- Rabies epidemiology and control
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Genomics and Phylogenetic Studies
- Probiotics and Fermented Foods
- RNA Research and Splicing
- RNA modifications and cancer
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Microbial Community Ecology and Physiology
- Viral Infections and Immunology Research
- RNA and protein synthesis mechanisms
University of Nottingham
2018-2024
Loughborough University
2021
Nottingham Trent University
2019-2020
Abstract The 3D architecture of RNAs governs their molecular interactions, chemical reactions, and biological functions. However, a large number protein complexes remain poorly understood due to the limitations conventional structural biology techniques in deciphering complex structures dynamic interactions. To address this limitation, we have benchmarked an integrated approach that combines cryogenic OrbiSIMS, state-of-the-art solid-state mass spectrometry technique, with computational...
Repeat spillover of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into new hosts has highlighted the critical role cross-species transmission coronaviruses and establishment reservoirs virus in pandemic epizootic spread coronaviruses. Species particularly susceptible to SARS-CoV-2 include Mustelidae (mink, ferrets related animals), cricetid rodents (hamsters felids (domestic cats animals) white-tailed deer. These predispositions led us screen British wildlife with...
Horseshoe bats are the natural hosts of Sarbecovirus subgenus that includes SARS-CoV and SARS-CoV- 2. Despite devastating impact COVID-19 pandemic, there is still little known about underlying epidemiology virology sarbecoviruses in their hosts, leaving large gaps our pandemic preparedness. Here we describe results PCR testing for two horseshoe bat species ( Rhinolophus hipposideros R. ferrumequinum ) present Great Britain, collected 2021–22 during peak pandemic. One hundred ninety seven...
Dichelobacter nodosus (D. nodosus) is the causative pathogen of ovine footrot, a disease that has significant welfare and financial impact on global sheep industry. Previous studies into phylogenetics D. have focused Australia Scandinavia, meaning current diversity in United Kingdom (U.K.) population its relationship globally, poorly understood. Numerous epidemiological methods are available for bacterial typing; however, few account whole genome or provide opportunity future application new...
Abstract Horseshoe bats are the natural hosts of Sarbecovirus subgenus that includes SARS-CoV-1 and 2. Despite devastating impacts COVID-19 pandemic, there is still little known about underlying epidemiology virology sarbecoviruses in their hosts, leaving large gaps our pandemic preparedness. Here we describe results PCR testing for two horseshoe bat species ( Rhinolophus hipposideros R. ferrumequinum ) present Great Britain, collected 2021-22 during peak pandemic. One hundred ninety seven...
Footrot is a polymicrobial infectious disease in sheep causing severe lameness, leading to one of the industry’s largest welfare problems. The complex etiology footrot makes situ or vitro investigations difficult.
The Caliciviridae family, comprising positive-sense RNA viruses, is characterised by its non-enveloped, small virions, broad host range, and notable tendency for switching. These viruses are primarily associated with gastroenteric disease, though they can lead to haemorrhagic or respiratory infections. Our study employed a metagenomics analysis of faecal samples from Stoats (Mustela erminea), identifying two novel Calicivirus species, tentatively named Stoat vesivirus valovirus. was...
The Caliciviridae family, comprising positive-sense RNA viruses, is characterised by its non-enveloped, small virions, broad host range, and notable tendency for switching. These viruses are primarily associated with gastroenteric disease, though they can lead to haemorrhagic or respiratory infections. Our study employed a metagenomics analysis of faecal samples from stoats (Mustela erminea), identifying two novel calicivirus species, named stoat vesivirus valovirus. Stoat was identified in...
The Caliciviridae family, comprising positive-sense RNA viruses, is characterised by its non-enveloped, small virions, broad host range, and notable tendency for switching. These viruses are primarily associated with gastroenteric disease, though they can lead to haemorrhagic or respiratory infections. Our study employed a metagenomics analysis of faecal samples from stoats (Mustela erminea), identifying two novel calicivirus species, named stoat vesivirus valovirus. Stoat was identified in...
The
Ovine footrot is a complex multifactorial infectious disease, causing lameness in sheep with major welfare and economic consequences. Dichelobacter nodosus the main causative bacterium; however, polymicrobial disease Fusobacterium necrophorum, Mycoplasma fermentans Porphyromonas asaccharolytica also associated. There limited understanding of host response involved. The proinflammatory mediators, interleukin (IL)-1β C-X-C Motif Chemokine Ligand 8 (CXCL8), have been shown to play role early D....
2. Abstract Repeat spillover of SARS-CoV-2 into new hosts has highlighted the critical role cross species transmission coronaviruses and establishment reservoirs virus in pandemic epizootic spread coronaviruses. Species particularly susceptible to spill-over include Mustelidae (mink, ferrets related animals), cricetid rodents (hamsters felids domestic cats animals) white tailed deer. These predispositions led us screen British wildlife with sarbecovirus specific qPCR pan coronavirus PCR...
Abstract Footrot and interdigital dermatitis are endemic infectious diseases in all sheep farming regions, impairing welfare production. The development of efficacious vaccines against the primary causative pathogen has been hampered by extensive antigenic diversity Dichelobacter nodosus. Understanding heterogeneity within between farms is essential if feasibility bespoke vaccine production to be assessed. In this study 56 ewe lamb isolates from 9 were compared D. nodosus serogroup Multi...
Abstract Background Footrot and interdigital dermatitis are endemic infectious diseases in all sheep farming regions, impairing welfare production. The development of efficacious vaccines against the primary causative pathogen has been hampered by extensive antigenic diversity Dichelobacter nodosus . Understanding heterogeneity within between flocks is essential if feasibility bespoke vaccine production to be assessed for use U.K. Results In this study 56 ewe lamb isolates from 9 were...
Abstract Background Footrot and interdigital dermatitis are endemic infectious diseases in all sheep farming regions, impairing welfare production. The development of efficacious vaccines against the primary causative pathogen has been hampered by extensive antigenic diversity Dichelobacter nodosus . Understanding heterogeneity within between flocks is essential if feasibility bespoke vaccine production to be assessed for use U.K. Results In this study 56 ewe lamb isolates from 9 were...
Abstract Footrot and interdigital dermatitis are endemic infectious diseases in all sheep farming regions, impairing welfare production. The development of efficacious vaccines against the primary causative pathogen has been hampered by extensive antigenic diversity Dichelobacter nodosus . Understanding heterogeneity within between farms is essential if feasibility bespoke vaccine production to be assessed for use U.K. In this study 56 ewe lamb isolates from 9 were compared D. serogroup...
Ovine footrot is a complex multifactorial infectious disease, causing lameness in sheep with major welfare and economic consequences. Dichelobacter nodosus the main causative bacterium, however, polymicrobial disease Fusobacterium necrophorum, Mycoplasma fermentans Porphyromonas asaccharolytica also associated. There limited understanding of host response involved. Proinflammatory mediators interleukin (IL)-1β C-X-C Motif Chemokine Ligand 8 (CXCL8) have been shown to play role early...
Abstract Footrot is a polymicrobial infectious disease in sheep causing severe lameness, leading to one of the industry’s biggest welfare problems. The complex aetiology footrot makes in-situ or in-vitro investigations difficult. Computational methods offer solution understanding bacteria involved, how they may interact with host and ultimately providing way identify targets for future hypotheses driven investigative work. Here we present first combined global analysis bacterial community...