A5003216635- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Suicide and Self-Harm Studies
- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Dermatology and Skin Diseases
- Blind Source Separation Techniques
- Neurogenesis and neuroplasticity mechanisms
- Visual perception and processing mechanisms
- Fractal and DNA sequence analysis
- Mental Health Research Topics
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Hearing, Cochlea, Tinnitus, Genetics
- Urticaria and Related Conditions
- Insect and Pesticide Research
- Mental Health Treatment and Access
Yale University
2018-2024
Bioscience (China)
2024
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
Nanjing Medical University
2020
Kangda College of Nanjing Medical University
2020
Chinese Academy of Sciences
2014-2017
Center for Excellence in Brain Science and Intelligence Technology
2017
Shanghai Institutes for Biological Sciences
2014-2016
University of Chinese Academy of Sciences
2014
Although itch sensation is an important protective mechanism for animals, chronic remains a challenging clinical problem. Itch processing has been studied extensively at the spinal level. However, how information transmitted to brain and what central circuits underlie itch-induced scratching behavior remain largely unknown. We found that spinoparabrachial pathway was activated during optogenetic suppression of this impaired behaviors. Itch-mediating neurons, which express gastrin-releasing...
The responses of visual cortical neurons to natural stimuli are both reliable and sparse. These properties require inhibition, yet the contribution specific types inhibitory is not well understood. Here we demonstrate that optogenetic suppression parvalbumin (PV)- but somatostatin (SOM)-expressing interneurons reduces response reliability in primary cortex anaesthetized awake mice. PV leads increases low firing rates decreases high neurons, resulting an overall reduction signal-to-noise...
Spontaneous neuronal ensemble activity in the hippocampus is believed to result from a combination of preconfigured internally generated dynamics and unique patterns driven by recent experience. Previous research has established that sequential (i.e., preplay) contribute expression future place cell sequences, which turn expressed post-experience replay). The relative contribution experience-related factors replay overall during post-run sleep be highly biased toward run experience, despite...
Abstract Both theoretical and experimental studies suggest that response properties in the visual system are shaped by signals natural environment. Recent showed that, primary cortex ( V 1), neurons preferring light decrements OFF stimuli) outnumber those increments ON stimuli). However, it is not clear whether ‐dominance 1 related to contrast statistics images. By analysing distribution of negative positive contrasts images at several spatial scales, we optimal coding would lead a...
Large-scale epidemiological surveys suggest that hearing loss (HL) is a significant risk factor for dementia. We previously showed noise-induced HL (NIHL) impairs hippocampal cognitive function and decreases neurogenesis neuronal complexity, suggesting causal role of in To further investigate the influence acquired peripheral on with aging process as well underlying mechanism, we produced NIHL male CBA/J mice assessed microglial morphology auditory brain hippocampus at 4 days post-noise...
We introduce a more flexible optogenetics-based mapping system attached on stereo microscope, which offers automatic light stimulation to individual regions of interest in the cortex that expresses light-activated channelrhodopsin-2 vivo. Combining simultaneous recording electromyography from specific forelimb muscles, we demonstrate this much better efficiency and precision distinct domains for controlling limb muscles mouse motor cortex. Furthermore, compact modular design also yields...
Clinicians are expected to provide accurate and useful mental health assessments, sometimes in emergency settings. The most urgent challenge may be calculating suicide risk. Unfortunately, existing instruments often fail meet requirements. To address this situation, we used a sustainable scale development approach create publicly available Suicidality Scale (SS). Following critical review of current measures, community input, panel discussions, an international item pool survey included...