A5044338560- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Advanced Memory and Neural Computing
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Pluripotent Stem Cells Research
- Regulation of Appetite and Obesity
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Greenhouse Technology and Climate Control
- Face Recognition and Perception
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Potato Plant Research
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Hearing Loss and Rehabilitation
Chinese Academy of Sciences
2016-2025
Center for Excellence in Brain Science and Intelligence Technology
2018-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2019-2024
Institut National Polytechnique Félix Houphouët-Boigny
2024
Laboratoire Plasma et Conversion d'Energie
2024
Institut National Polytechnique de Toulouse
2024
École Nationale Supérieure d'Électrotechnique, d'Électronique, d'Informatique, d'Hydraulique et des Télécommunications
2024
Shanghai Institutes for Biological Sciences
2009-2020
Tohoku University
2010-2013
University of California, Berkeley
2001-2007
Mapping single-neuron projections is essential for understanding brain-wide connectivity and diverse functions of the hippocampus (HIP). Here, we reconstructed 10,100 projectomes mouse HIP classified 43 projectome subtypes with distinct projection patterns. The number targets axon-tip distribution depended on soma location along longitudinal transverse axes. Many were enriched in specific subdomains defined by spatial transcriptomic profiles. Furthermore, delineated comprehensive wiring...
Abstract The orbitofrontal cortex (OFC) encodes expected outcomes and plays a critical role in flexible, outcome-guided behavior. OFC projects to primary visual (V1), yet the function of this top-down projection is unclear. We find that optogenetic activation V1 reduces amplitude responses via recruitment local somatostatin-expressing (SST) interneurons. Using mice performing Go/No-Go task, we show mediates outcome-expectancy modulation reward-irrelevant No-Go stimulus. Furthermore,...
The responses of visual cortical neurons to natural stimuli are both reliable and sparse. These properties require inhibition, yet the contribution specific types inhibitory is not well understood. Here we demonstrate that optogenetic suppression parvalbumin (PV)- but somatostatin (SOM)-expressing interneurons reduces response reliability in primary cortex anaesthetized awake mice. PV leads increases low firing rates decreases high neurons, resulting an overall reduction signal-to-noise...
Tau pathogenesis is a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD). Although the events leading to initial tau misfolding and subsequent spreading in patient brains are largely unknown, traumatic brain injury (TBI) may be risk factor for tau-mediated neurodegeneration. Using repetitive TBI (rTBI) paradigm, we report that rTBI induced somatic accumulation phosphorylated misfolded tau, as well neurodegeneration across multiple areas 7-month-old transgenic...
As an important animal model to study the relationship between behaviour and neural activity, mouse is able perform a variety of visual tasks, such as orientation discrimination contrast detection. However, it not clear how stimulus influences performance in mice. In this study, we used two task designs, two-alternative forced choice (2AFC) go/no-go, examine mice discriminate orthogonal orientations at different contrasts. We found that tended increase with contrast, high was better when set...
Highlights•D1- and D2-MSNs in VLS exhibit different oscillatory phases relative to lick cycle•Transient inactivation of D1-MSNs reduces probability individual spout contact•D1- oppositely regulate the responses SNr neurons during lickingSummaryDrinking behavior rodents is characterized by stereotyped, rhythmic licking movement, which regulated basal ganglia. It unclear how direct indirect pathways control bout contact. We find that inactivating D1 D2 receptor-expressing medium spiny (MSNs)...
Visual stimuli are known to induce various changes in the receptive field properties of adult cortical neurons, but underlying mechanisms not well understood. Repetitive pairing at two orientations can a shift orientation tuning, with direction and magnitude depending on temporal order interval between pair. Although specificity effect tens milliseconds strongly suggests spike-timing-dependent synaptic plasticity (STDP) as mechanism, it remains unclear whether modification occurs within...
Adaptive action selection during stimulus categorization is an important feature of flexible behavior. To examine neural mechanism underlying this process, we trained mice to categorize the spatial frequencies visual stimuli according a boundary that changed between blocks trials in session. Using model with dynamic decision criterion, found sensory history was for adaptive after switch boundary. Bilateral inactivation secondary motor cortex (M2) impaired by reducing behavioral influence...
Levodopa-induced dyskinesia (LID) is an intractable motor complication arising in Parkinson's disease with the progression of and chronic treatment levodopa. However, specific cell assemblies mediating have not been fully elucidated. Here, we utilize activity-dependent tool to identify three brain regions (globus pallidus external segment [GPe], parafascicular thalamic nucleus, subthalamic nucleus) that specifically contain dyskinesia-activated ensembles. An intensity-dependent hyperactivity...
Abstract Both theoretical and experimental studies suggest that response properties in the visual system are shaped by signals natural environment. Recent showed that, primary cortex ( V 1), neurons preferring light decrements OFF stimuli) outnumber those increments ON stimuli). However, it is not clear whether ‐dominance 1 related to contrast statistics images. By analysing distribution of negative positive contrasts images at several spatial scales, we optimal coding would lead a...
Unconscious processing of subliminal visual information, as illustrated by the above-chance accuracy in discriminating invisible stimuli, is evident both blindsight patients and healthy human observers. However, dependence such unconscious on stimulus properties remains unclear. Here we studied impact luminance complexity extent processing. A testing presented to one eye was rendered a masking other eye, participants made forced-choice discrimination identity followed report perceptual...
Significance Fast sensory processing, critical for the survival of animals, is usually achieved in a vigilant state characterized by cortical desynchronization. To understand neural substrate such fast we examined brain modulation response latency rat primary visual cortex (V1). We found that V1 neurons shorter desynchronized than synchronized state. Increase membrane conductance single contributes to but cannot fully account observed advance. Such faster explained cumulative advance along...
Abstract As an epigenetic modulator of gene expression, Methyl-CpG binding protein 2 (MeCP2) is essential for normal neurological function. Dysfunction MeCP2 associated with a variety disorders. MECP2 duplication in human causes neuropsychiatric symptoms such as mental retardation and autism. overexpression mice results neurobehavioural disorders, dendritic abnormalities, synaptic defects. However, how gain function influences cortical processing sensory information remains unclear. In this...
The secondary motor cortex (M2) encodes choice-related information and plays an important role in cue-guided actions. M2 neurons innervate the dorsal striatum (DS), which also contributes to decision-making behavior, yet how modulates signals DS influence perceptual is unclear. Using mice performing a visual Go/No-Go task, we showed that inactivating projections impaired performance by increasing false alarm (FA) rate reward-irrelevant No-Go stimulus. choice signal of correlated with...
Background Visual perception is usually stable and accurate. However, when the two eyes are simultaneously presented with conflicting stimuli, falls into a sequence of spontaneous alternations, switching between one stimulus other every few seconds. Known as binocular rivalry, this visual illusion decouples subjective experience from physical stimulation provides unique opportunity to study neural correlates consciousness. The temporal properties alternating have been intensively...
The perceived speed of motion in one part the visual field is influenced by its surrounding fields. Little known about cellular mechanisms causing this phenomenon. Recordings from mammalian cortex revealed that preference cortical cells could be changed displaying a contrast cell’s classical receptive field. neuron’s selectivity shifted to prefer faster if contextual surround was set at relatively lower speed, and vice versa. These specific center–surround interactions may underlie...