A5026611408- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Inflammatory Bowel Disease
- Cardiac Valve Diseases and Treatments
- Melanoma and MAPK Pathways
- Aortic Disease and Treatment Approaches
- Cutaneous Melanoma Detection and Management
- Diagnosis and treatment of tuberculosis
- MRI in cancer diagnosis
- Traumatic Ocular and Foreign Body Injuries
- Aortic aneurysm repair treatments
- Microscopic Colitis
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Autopsy Techniques and Outcomes
- Biosimilars and Bioanalytical Methods
- Medical and Biological Sciences
- Nutrition and Health in Aging
- Computational Drug Discovery Methods
- Radiation Dose and Imaging
- Dental Radiography and Imaging
- Cardiovascular Syncope and Autonomic Disorders
- Advanced X-ray and CT Imaging
Yale University
2024-2025
Royal Surrey County Hospital
2024
Tallaght University Hospital
2017-2023
Cairo University
2020
Washington University in St. Louis
2018
St. Vincent's University Hospital
2007-2017
Northwestern University
2014-2017
Trinity College Dublin
2017
Beth Israel Deaconess Medical Center
2017
Addenbrooke's Hospital
2016-2017
To improve velocity-to-noise ratio (VNR) and dynamic velocity range of 4D flow magnetic resonance imaging (MRI) by using dual-velocity encoding (dual-venc) with k-t generalized autocalibrating partially parallel acquisition (GRAPPA) acceleration.A dual-venc MRI sequence GRAPPA acceleration was developed a shared reference scan followed three-directional low- high-venc scans (repetition time / echo flip angle = 6.1 msec 3.4 15°, temporal/spatial resolution 43.0 msec/1.2 × 1.2 mm3 ). The data...
Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients primary performed using histological biomarkers such as tumor thickness ulceration. As disruption epigenomic landscape recognized a widespread feature inherent in development progression, we aimed to identify novel providing additional clinical information over current factors unbiased genome-wide DNA methylation analyses.We comprehensive analysis during all...
Four-dimensional (4D) flow magnetic resonance imaging (MRI) was employed for the simultaneous assessment of morphometry and parameters along thoracic aorta to investigate associations between flow, age, diameter, aortic valve morphology. One hundred sixty-five subjects, 65 controls, 50 patients with bicuspid (BAV), a dilated aorta, tricuspid (TAV) underwent 4D MRI. Following 3D segmentation vessel centreline calculated used extract peak systolic velocity, normalized displacement. Validation...
Abstract Aim False‐negative mammograms may result in a delay breast carcinoma diagnosis and have important implications for patient care. In this study, the characteristics of symptomatic patients with false‐negative were analysed. Methods Patients identified over 10‐year period (1994–2004). One hundred twenty‐four had preoperative 1241 abnormal mammograms. Clinical presentation, diagnostic methods pathology reviewed by specialist radiologist. Results Following retrospective review, 42%...
Obesity, sarcopenia, and myosteatosis in inflammatory bowel disease may confer negative outcomes, but their prevalence impact among patients with Crohn's (CD) have not been systematically studied. The aim of this study was to assess nutritional status body composition undergoing resectional surgery for CD determine on operative outcomes.
Abstract Introduction Polysomnography (PSG) is the gold standard for objective sleep measurement, but may not represent habitual due to first-night effect (FNE). This study quantified FNE by comparing total time (TST) and wake after onset (WASO) from one night of home-based PSG contiguous measures an electroencephalography (EEG)-measuring headband averaged over multiple nights. Methods Sixty-three community-living adults ≥55 years with symptoms insomnia and/or daytime sleepiness ≥once/week...
Purpose To test the feasibility of a quiescent interval low-angle shot (QLASH) sequence for nonenhanced MR angiography (MRA) extracranial carotid arteries at 3 T. Methods The were imaged using QLASH MRA in healthy volunteers and patients with arterial disease. impact three gating strategies (electrocardiographic-gated, pulse-gated, ungated) was evaluated. Image quality comparisons made respect to two-dimensional (2D) time flight (TOF) contrast-enhanced (CEMRA) patients. Stenoses graded....
atients with clinical suspicion of malignant prostate neoplasm (i.e., elevated prostate-specific antigen [PSA], suspicious nodule on digital rectal examination) typically undergo systematic transrectal ultrasonography (TRUS)-guided sectoral biopsy; however, the overall yield initial biopsy is 22%-29% (1, 2).Potential reasons for false negative TRUS include sampling error or technical limitation due to location tumor.Anteriorly located tumors, where dominant tumor mass anterior urethra...
Objectives: This study retrospectively applied Wells’ score and YEARS algorithm to the same sample of patients evaluate predictive performance each when compared with gold standard CT pulmonary angiography. Design: Retrospective analytical study. Setting: A tertiary University Hospital in Ireland. Patients: Data from 794 who underwent angiography rule out embolism. Interventions: Patients were analyzed using retrospective application both algorithm. Sensitivity, specificity, diagnostic odds...
Purpose To quantify the accuracy of three‐dimensional (3D) radial arterial spin labeled (ASL) magnetic resonance angiography (MRA) using vascular models carotid stenosis. Methods Eight were imaged at 1.5 Tesla pulsatile flow waveforms rates found in internal arteries (100–400 mL/min). The impacts 3D ASL imaging readout (fast low angle shot (FLASH) versus balanced steady‐state free precession (bSSFP)), ultrashort echo time a pointwise encoding reduction with acquisition (PETRA), and model...
Purpose We hypothesized that non–contrast‐enhanced MR angiography (NEMRA) could be performed without cardiac gating by using a variant of the quiescent‐inflow single‐shot (QISS) technique. Methods Ungated QISS (UnQISS) MRA was evaluated in eight patients with peripheral arterial disease at 1.5T. The radial acquisition used optimized azimuthal equidistant projections, long quiescent inflow time (1200 ms) to ensure replenishment saturated in‐plane spins irrespective phase, and lengthy readout...
To evaluate ungated nonenhanced hybridized arterial spin labeling (hASL) magnetic resonance angiography (MRA) of the extracranial carotid arteries using a fast low angle shot (FLASH) readout at 3 Tesla. In this retrospective, institutional review board-approved and HIPAA-compliant study, we evaluated image quality (4-point scale) hASL MRA FLASH with respect to contrast-enhanced (CEMRA) in 37 patients presenting neurologic symptoms. Two certified neuroradiologists independently 407 segments...
Because of advances in targeted therapies, the clinical evaluation cutaneous melanoma is increasingly based on a combination traditional histopathology and molecular pathology. Therefore, it necessary to expand our knowledge events that accompany development progression optimize management. The central objective this study was increase mutational complement progression. High-throughput genotyping adapted query 159 known single nucleotide mutations 33 cancer-related genes across two cohorts...
The homeobox containing transcription factor MSX2 is a key regulator of embryonic development and has been implicated to have role in breast pancreatic cancer.Using selection two- three-dimensional vitro assays tissue microarrays (TMAs), the clinical functional relevance malignant melanoma was explored. A doxycyline-inducible over-expression system applied study vitro. For TMA construction, tumour material from 218 patients used.Ectopic expression resulted induction apoptosis reduced...