A5000775960- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Voice and Speech Disorders
- Bone Tissue Engineering Materials
- Polyamine Metabolism and Applications
- Acoustic Wave Phenomena Research
- 3D Printing in Biomedical Research
- Tracheal and airway disorders
- Advanced Proteomics Techniques and Applications
- Speech Recognition and Synthesis
- Peptidase Inhibition and Analysis
- Dysphagia Assessment and Management
- Mast cells and histamine
University of North Carolina at Chapel Hill
2020-2024
North Carolina State University
2020-2024
This study represents the first proof-of-concept standardized automated multi-tissue decellularization protocol for derivation of ECM biomaterials.
Microphysiological and organ-on-chip platforms seek to address critical gaps in human disease models drug development that underlie poor rates of clinical success for novel interventions. While the fabrication technology model cells used synthesize organs-on-chip have advanced considerably, most rely on animal-derived or synthetic extracellular matrix as a cell substrate, limiting mimicry physiology precluding use modeling diseases which dynamics play role pathogenesis. Here, cell-derived...
Mast cells (MCs) are pro-inflammatory tissue-resident immune that play a key role in inflammation. MCs circulate peripheral blood as progenitors and undergo terminal differentiation the tissue microenvironment where they can remain for many years. This situ maturation results tissue- species-specific MC phenotypes, culminating significant variability response to environmental stimuli. There challenges associated with studying mature tissue-derived MCs, particularly humans. In cases cultured...
The vocal folds (VFs) are constantly exposed to mechanical stimulation leading changes in biomechanical properties, structure, and composition. development of long-term strategies for VF treatment depends on the characterization related cells, biomaterials, or engineered tissues a controlled environment. Our aim was design, develop, characterize scalable high-throughput platform that mimics microenvironment VFs vitro. consists 24-well plate fitted with flexible membrane atop waveguide...