A5043807840- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Erythropoietin and Anemia Treatment
- Vascular Malformations Diagnosis and Treatment
- Cancer Cells and Metastasis
- Gas Sensing Nanomaterials and Sensors
- Dialysis and Renal Disease Management
- Vascular Malformations and Hemangiomas
- Ophthalmology and Visual Health Research
- Cardiac Fibrosis and Remodeling
- Conducting polymers and applications
- Artificial Intelligence in Healthcare
- Congenital heart defects research
- Retinal Imaging and Analysis
- Blood properties and coagulation
- Bone Tissue Engineering Materials
- Pluripotent Stem Cells Research
- Thermoregulation and physiological responses
- Lymphatic System and Diseases
- Ergonomics and Musculoskeletal Disorders
- Intracranial Aneurysms: Treatment and Complications
- Spaceflight effects on biology
- Vascular Tumors and Angiosarcomas
University of North Carolina at Chapel Hill
2022-2025
North Carolina State University
2022-2025
University of North Carolina Health Care
2023
Gandhi Medical College & Hospital
2022
Seoul National University
2017-2021
University of Seoul
2017
Endothelial cells are a heterogeneous population with various organ-specific and conserved functions that critical to organ development, function, regeneration. Here we report Sox17-Erg direct reprogramming approach uses cardiac fibroblasts create differentiated endothelial demonstrate endothelial-like molecular physiological in vitro vivo. Injection of these induced into myocardial infarct sites after injury results improved vascular perfusion the scar region. Furthermore, use genomic...
Efficient delivery of oxygen and nutrients to tissues requires an intricate balance blood, lymphatic, interstitial fluid pressures (IFPs), gradients in pressure drive the flow lymph, through tissues. While specific mechanical stimuli, such as wall shear stress, have been shown modulate cellular signaling pathways along with gene protein expression patterns, understanding key signals imparted by flowing how these are integrated across multiple cells cell types native is incomplete due...
Abstract Cardiovascular disease is the cause of death in ≈50% hemodialysis patients. Accumulation uremic solutes systemic circulation thought to be a key driver endothelial dysfunction that underlies elevated cardiovascular events. A challenge understanding mechanisms relating chronic kidney lack vitro models allow screening effects environment on endothelium. Here, method described for microfabrication human blood vessels from donor cells and perfused with serum. The resulting donor‐derived...
Microphysiological and organ-on-chip platforms seek to address critical gaps in human disease models drug development that underlie poor rates of clinical success for novel interventions. While the fabrication technology model cells used synthesize organs-on-chip have advanced considerably, most rely on animal-derived or synthetic extracellular matrix as a cell substrate, limiting mimicry physiology precluding use modeling diseases which dynamics play role pathogenesis. Here, cell-derived...
Somatic activating mutations in PIK3CA are common drivers of vascular and lymphatic malformations. Despite biophysical signatures tissues susceptible to lesion formation, including compliant extracellular matrix low rates perfusion, lesions vary clinical presentation from localized cystic dilatation diffuse infiltrative dysplasia. The mechanisms driving the differences disease severity variability role microenvironment potentiating progression poorly understood. Here, we investigate...
Aim : To correlate HbA1c level with macular thickness in type 2 diabetic patients to determine the impact of blood sugar control on retina. Methods This cross-sectional study was conducted GMERS Medical College and Civil Hospital, Gandhinagar which 240 diabetes mellitus were included who presented at Department Ophthalmology. Result Out patients, 209 had high (>6.5 %) while 31 normal (<6.5 %). From more than 6.5 %, 111 retinopathy 98 didn't have retinopathy. those 89 oedema (macular...
Impedance measurement is a widely used technique for monitoring ion species in various applications. In plant cultivation, the impedance system to measure electrical conductivity (EC) of nutrient solutions. Recent research has shown that quality and quantity horticultural crops, e.g. tomato, can be optimized by controlling salinity However, understanding detailed response solution not possible until fruit fully grown or sacrificing stem. To overcome this issue, crop cultivation requires...
Abstract The flexible strain sensors have potential applications in advanced electronics, health monitoring systems, wearable sensors, robotics, and human–machine interfaces. development of highly sensitive, stretchable, durable is a challenging task for researchers. However, the with detection range from large to minute deflection are imperative human‐interactive applications. This work has demonstrated facile method sensor fabrication, which use reduced graphene oxide (rGO) as sensing...
Several cardiovascular pathologies and aging have been associated with alterations in the mechanical structural properties of vascular wall, leading to a reduction arterial compliance development constriction.
In this era of proliferating growth technical advancements, vehicles have become an integral part human life. Every vehicle has its own emission polluting gases, but the problem occurs when do not get serviced regularly and is beyond standardized value. [1]The primary reason for breach level being incomplete combustion fuel supplied to engine which due improper maintenance vehicles. This from cannot be completely avoided it can definitely controlled. The aim project monitor control...
Fibroblasts align and show persistent migration on ridge-pillar micropatterned substrates. Traction forces vary along the polarized cell length.
In the past, significant effort has been made to develop ultrathin membranes exhibiting physiologically relevant mechanical properties, such as thickness and elasticity of native basement membranes. However, most these fabricated have a relatively high elastic modulus, ∼MPa–GPa, only retinal epithelial Vascular low ∼kPa, on contrary, seldom mimicked. Membranes demonstrating compliance, with moduli ranging in ∼kPa along sub-microscale thicknesses rarely reported, would be ideal mimic vascular...
Interstitial fluid pressure gradients and interstitial flow have been shown to drive morphogenic processes that shape tissues influence progression of diseases including cancer. The advent porous media microfluidic approaches has enabled investigation the cellular response flow, but questions remain as critical biophysical biochemical signals imparted by resulting on resident cells extracellular matrix (ECM). Here, we introduce a low-cost method maintain physiological pressures is built from...
Abstract Cardiovascular disease is a leading cause of mortality in individuals with chronic kidney disease. Hypertension, common among patients disease, major contributor to both damage and the heightened cardiovascular risk these patients. Advanced associated elevated levels circulating uremic toxins, particularly indoxyl sulfate p-cresyl sulfate, are known exacerbate by promoting inflammatory processes, including monocyte adhesion, rolling, extravasation. However, despite established link...
Abstract Somatic activating mutations in PIK3CA are common drivers of vascular and lymphatic malformations. Despite biophysical signatures tissues susceptible to lesion formation, including compliant extracellular matrix low rates perfusion, lesions vary clinical presentation from localized cystic dilatation diffuse infiltrative dysplasia. The mechanisms driving the differences disease severity variability role microenvironment potentiating progression poorly understood. Here, we investigate...
Rathod, Mitesh; Aw, Wen Yih; Doherty, Elizabeth L.; Xi, Gang; Roy-Chaudhury, Prabir; Polacheck, William J. Author Information
AIM– to study causes of vision impairment in school going children, with focus on refractive errors and the unmet need spectacles them. Prospective analysis 500 children (up 14METHOD– years age) visiting a tertiary care teaching Institute Ahmedabad who were willing comply procedure enrolled study. Refractive error was main cause 58.6% eyes impairment, amblyopia inRESULTS– 15.2% while other 4.3%. Out which, maximum number had astigmatism (200), followed by Myopia (160) Hypermetropia (70). In...