A5062109748- Renal cell carcinoma treatment
- Renal and related cancers
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Genetic and Kidney Cyst Diseases
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- COVID-19 Impact on Reproduction
- Pregnancy and preeclampsia studies
- Radiomics and Machine Learning in Medical Imaging
- Reproductive System and Pregnancy
- Fetal and Pediatric Neurological Disorders
- Breast Cancer Treatment Studies
- Urologic and reproductive health conditions
- Inflammatory Biomarkers in Disease Prognosis
- Ion Transport and Channel Regulation
- vaccines and immunoinformatics approaches
Universitair Ziekenhuis Leuven
2019-2025
KU Leuven
1994-2024
Maastricht University
2007-2023
University Medical Center
2023
Antwerp University Hospital
2014-2019
University of Antwerp
2017
Maastricht University Medical Centre
2006-2015
Sidney Kimmel Comprehensive Cancer Center
2011
Johns Hopkins University
2011
Ghent University
2011
Perinatal death is an increasingly important problem as the coronavirus disease 2019 (COVID-19) pandemic continues, but mechanism of has been unclear.To evaluate role placenta in causing stillbirth and neonatal following maternal infection with COVID-19 confirmed placental positivity for severe acute respiratory syndrome 2 (SARS-CoV-2).Case-based retrospective clinicopathologic analysis by a multinational group 44 perinatal specialists from 12 countries autopsy pathology findings 64...
Context.— The number of neonates with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is increasing, and in a few there are reports intrauterine infection. Objective.— To characterize the placental pathology findings preselected cohort infected by transplacental transmission arising from maternal SARS-CoV-2, to identify risk factors for fetal Design.— Case-based retrospective analysis multinational group 19 perinatal specialists cohorts infants delivered mothers...
Abstract The genetic and epigenetic alterations that underlie cancer pathogenesis are rapidly being identified. This provides novel insights in tumor biology as well potential biomarkers. somatic mutations genes have been implemented clinical practice defined very specific. For alterations, more specifically aberrant methylation of promoter CpG islands, evidence is emerging these markers could be used for the early detection prediction prognosis response to therapy. However, exact location...
Context.— SARS-CoV-2 can undergo maternal–fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARS-CoV-2. Hofbauer cells are macrophages that have been involved viral diseases, including HIV Zika virus, but their involvement unknown. Objective.— To determine whether extend beyond to enter...
Clear cell renal carcinoma (CC-RCC) is a highly vascularised tumour and therefore an attractive disease to study angiogenesis test novel inhibitors in early clinical development. Endothelial proliferation plays pivotal role the process of angiogenesis. The aim this was compare parameters low nuclear grade (n=87) vs high CC-RCC (n=63). A panel antibodies used for immunohistochemistry: CD34/Ki-67, carbonic anhydrase IX, hypoxia-inducible factor-1α (HIF-1α) vascular endothelial growth factor...
Purpose: The currently used prognostic models for patients with nonmetastatic clear cell renal carcinoma (ccRCC) are based on clinicopathologic features and might be improved by adding molecular markers. Epigenetic alterations occur frequently in ccRCC promising biomarkers. aim of this study is to identify promoter methylation markers ccRCC.Experimental Design: We integrated data generated massive parallel sequencing methyl-binding domain enriched DNA microarray-based RNA expression...
In this era of molecular diagnostics, prediction clear-cell renal cell cancer (ccRCC) survival requires optimization, as current prognostic markers fail to determine individual patient outcome. Epigenetic events are promising markers. Promoter CpG island methylation cysteine dioxygenase type 1 (CDO1), which was identified marker for breast cancer, is studied a potential ccRCC survival.
Although Blake's pouch cyst (BPC) is frequently mentioned in the spectrum of posterior fossa cysts and cystlike malformations since its first description 1996, natural history, clinical presentation, specific imaging characteristics, optimal treatment, outcome are relatively unknown. Consequently, BPC may still be underdiagnosed. We therefore report six cases ranging from a fatal hydrocephalus young boy, over an increasing head circumference with or without impaired neurological development...
As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent factors RCC. The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55–69 years. At baseline, diet lifestyle were assessed questionnaires. After 17.3 years of follow-up, 485 RCC cases 4438 subcohort members available analyses. Sodium increased (P-trend=0.03), whereas did not. For high sodium low intake, the...
Only a few recent phase III trials with targeted therapies or immune checkpoint inhibitors (ICIs) in metastatic clear-cell renal cell carcinoma (m-ccRCC) demonstrated an overall survival (OS) benefit compared to standard of care. We aimed study the evolution OS since start systemic therapy from 2000 2020.Retrospective on all consecutively treated m-ccRCC patients three Belgian hospitals starting therapy. The outcome was used univariable Cox model for year as predictor, and multivariable...
Abstract The goal of this retrospective, multicenter study was to evaluate the ability a newly developed refinement quantitative methylation-specific PCR assay detect prostate cancer in histopathologically negative biopsy samples collected from men who were later positively diagnosed during follow-up procedure. Biomarkers tested included much-studied glutathione-S-transferase P1 gene and others reported be frequently methylated cancer. Core tissue subjects with serial biopsies served as...
Genomic duplications of varying lengths at Xq26–q27 involving SOX3 have been described in families with X‐linked hypopituitarism. Using array‐CGH we detected a 1.1 Mb microduplication Xq27 large family three males suffering from The duplication was mapped 138.7 to 139.8 Mb, harboring only two annotated genes, and ATP11C , shown be direct tandem copy number gain. Unexpectedly, the did not fully segregate disease this suggesting that variable penetrance for In same family, female fetus...
394 Background: High-risk prostate cancer (PCa) patients have a high risk of biochemical recurrence (BCR) and metastatic progression following local therapy. The ARNEO trial is double-blind, placebo-controlled trial, evaluating the role neoadjuvant degarelix with or without apalutamide before radical prostatectomy (RP) in men high-risk PCa. Previously, we demonstrated that receiving + (n=45) had significantly better pathological response terms pT2 disease (51% vs. 27%; p=0.022) minimal...