A5059701092- Pregnancy and preeclampsia studies
- Ovarian cancer diagnosis and treatment
- Maternal and fetal healthcare
- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Prenatal Screening and Diagnostics
- COVID-19 Impact on Reproduction
- Maternal and Perinatal Health Interventions
- Reproductive System and Pregnancy
- Foreign Body Medical Cases
- Autopsy Techniques and Outcomes
- Esophageal and GI Pathology
- Neonatal Health and Biochemistry
- Genetic Syndromes and Imprinting
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Gestational Trophoblastic Disease Studies
- Renal and related cancers
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Epigenetics and DNA Methylation
- Photoacoustic and Ultrasonic Imaging
- Fetal and Pediatric Neurological Disorders
- Ectopic Pregnancy Diagnosis and Management
- Grief, Bereavement, and Mental Health
University of Pennsylvania
2018-2025
Children's Hospital of Philadelphia
2017-2025
Philadelphia University
2024
RELX Group (United States)
2023
University of Alabama at Birmingham
2022
Massachusetts General Hospital
2022
NorthShore University HealthSystem
2022
Harvard University
2022
Cornell University
2022
ORCID
2021
Context.— The number of neonates with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is increasing, and in a few there are reports intrauterine infection. Objective.— To characterize the placental pathology findings preselected cohort infected by transplacental transmission arising from maternal SARS-CoV-2, to identify risk factors for fetal Design.— Case-based retrospective analysis multinational group 19 perinatal specialists cohorts infants delivered mothers...
Objectives/Hypothesis Ingestion of button batteries (BB) can rapidly lead to caustic esophageal injury in infants and children, resulting significant morbidity mortality. To identify novel mitigation strategies, we tested common weakly acidic household beverages, viscous liquids, Carafate® for their ability act as protective irrigations until endoscopic removal the BB. Study Design Cadaveric live animal model. Methods Apple juice, orange Gatorade®, POWERADE®, pure honey, maple syrup, were...
Neurotrophic tyrosine receptor kinase (NTRK) fusions have been described as oncogenic drivers in a variety of tumors. However, little is known about the overall frequency NTRK fusion unselected pediatric Here, we assessed frequency, partners, and clinical course patients with fusion-positive tumors.We studied 1,347 consecutive tumors from 1,217 who underwent tumor genomic profiling using custom-designed DNA RNA next-generation sequencing panels. identified were orthogonally confirmed.NTRK 29...
Human γ9δ2 T cells potently inhibit pathogenic microbes, including intracellular mycobacteria, but the key inhibitory mechanism(s) involved have not been identified. We report a novel mechanism involving inhibition of mycobacteria by soluble granzyme A. produced factors that could pass through 0.45 µm membranes and in human monocytes cultured below transwell inserts. Neutralization TNF-α co-cultures infected prevented inhibition, suggesting was critical factor cells. However, only siRNA-...
Context.— SARS-CoV-2 can undergo maternal–fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARS-CoV-2. Hofbauer cells are macrophages that have been involved viral diseases, including HIV Zika virus, but their involvement unknown. Objective.— To determine whether extend beyond to enter...
Importance Neurodevelopmental outcomes for children with congenital heart defects (CHD) have improved minimally over the past 20 years. Objectives To assess feasibility and tolerability of maternal progesterone therapy as well magnitude effect on neurodevelopment fetuses CHD. Design, Setting, Participants This double-blinded individually randomized parallel-group clinical trial vaginal natural vs placebo in participants carrying CHD was conducted between July 2014 November 2021 at a...
Background The pathology that underlies morbidly adherent placenta (MAP) is poorly understood. objective of this study was to describe the placental pathology, especially implantation site associated with MAP. Methods This a single institution, retrospective case-control design examining placentas patients who delivered between January 2008 and September 2013. MAP cases were defined by need for clinical intervention at delivery beyond spontaneous or simple manual extraction placenta....
Spinal muscular atrophy type 0 is the most severe phenotype of disease, with patients presenting contractures, weakness, and respiratory failure at birth, typically fatal within weeks. We describe case a patient spinal who was treated both nusinersen onasemnogene abeparvovec. She has made modest motor improvements since treatment initiation 30-point improvement in CHOP-INTEND score, continues to make gains age 13 months without regression function, although she remains profoundly weak....
The widespread coronavirus disease 2019 (COVID-19) is caused by infection with the novel SARS-CoV-2. Currently, we have limited understanding of which cells become infected SARS-CoV-2 in human tissues and where viral RNA localizes on subcellular level. Here, present a platform for preparing autopsy tissue visualizing using fluorescence situ hybridization (FISH) amplification chain reaction. We developed probe sets that target different regions (including ORF1a N), as well specifically...
Antenatal diagnosis of morbidly adherent placenta has been shown to improve outcomes, but existing predictors lack sensitivity. Our objective was determine whether the presence myometrial fibres attached placental basal plate (BPMYO) in an antecedent pregnancy is associated with subsequent placenta.A case-control study.Departments Obstetrics and Gynecology Pathology, Northwestern University, Chicago, IL, USA.Women who had at least two pregnancies pathological evaluation.Cases were defined as...
ABSTRACT Objective To investigate the exome sequencing (ES) detection rate among fetuses with congenital anomalies and describe rates in setting of multiple versus isolated anomalies, perinatal autopsy, family history a previously affected child. Methods A single‐center retrospective chart review was conducted on 397 anomalous that underwent ES from May 2012 through December 2023. Medical record included demographics, imaging, genetic testing. Results The overall diagnostic 34.3%. diagnosis...
Background We lack early biomarkers for predicting neurodevelopment (ND) outcomes in children with congenital heart disease (CHD). Placentas of fetuses CHD have abnormalities, including unbalanced fetal/placental weight ratios (F/P). Although DNA methylation profiles revealed insights into the maternal-fetal environment (MFE), it is unknown if correlates to normalized F/P ratio groups and how these differences relate ND outcomes. Methods prospectively recruited a cohort pregnant women...
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and resulting disease (COVID‐19) cause placental dysfunction, which increases the risk of adverse pregnancy outcomes. While abnormal pathology from COVID‐19 is common, direct placenta rare. This suggests that pathophysiology associated with maternal COVID‐19, rather than infection, responsible for dysfunction. We hypothesized circulating extracellular vesicles (EVs), altered by during pregnancy, contribute to To...
Abstract Purpose: Adult granulosa cell tumor (AGCT) is characterized by the somatic FOXL2 p.C134W mutation, and recurrences have been associated with TERT promoter KMT2D-truncating mutations. Conversely, molecular underpinnings of rare juvenile (JGCT) not well elucidated. To this end, we applied a tumor-only integrated approach to investigate genomic, transcriptomic, epigenomic landscape 31 JGCTs identify putative oncogenic drivers. Experimental Design: Multipronged analyses were performed...
Placental health may impact the development and outcomes of congenital heart disease (CHD). CHD fetuses have been shown retrospectively to decreased placental blood flow. The purpose this study was determine if with flow pathology at birth there is a relationship between flow, pathology, outcomes. We performed prospective case-control 38 fetuses, including 28 single ventricle physiology 36 controls. Demographic, clinical, postnatal biometric data were collected. Umbilical venous volume...
Patients with Beckwith-Wiedemann syndrome (BWS), an epigenetic imprinting disorder involving alterations in genes at the 11p15 chromosomal location, are predisposed to develop hepatoblastomas (HBs), which rare embryonal liver tumors. Tumors can after a BWS diagnosis or, conversely, be presenting feature leading subsequent diagnosis. While HBs cardinal tumors of BWS, not all patients spectrum will HBs. This observation has led many hypotheses, including genotype-associated risk, tissue...