A5050996890- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Foreign Body Medical Cases
- Obstructive Sleep Apnea Research
- Esophageal and GI Pathology
- Anesthesia and Sedative Agents
- Cancer Cells and Metastasis
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience of respiration and sleep
- Emergency and Acute Care Studies
- Head and Neck Surgical Oncology
- Restraint-Related Deaths
- Sinusitis and nasal conditions
- Ear Surgery and Otitis Media
- Tumors and Oncological Cases
- Trauma Management and Diagnosis
- Head and Neck Cancer Studies
- Respiratory Support and Mechanisms
- Reconstructive Facial Surgery Techniques
- COVID-19 and healthcare impacts
- Anesthesia and Pain Management
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Nosocomial Infections in ICU
- Vascular Malformations and Hemangiomas
The Ohio State University Wexner Medical Center
2013-2025
Nationwide Children's Hospital
2016-2025
The Ohio State University
2012-2025
University of Michigan
2016
Nationwide Mutual Insurance Company (United States)
2013
Northwestern University
2011
Cleveland Clinic
2009
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2006
The optimization of a purely negative depletion, enrichment process for circulating tumor cells (CTCs) in the peripheral blood head and neck cancer patients is presented. uses red cell lysis step followed by immunomagnetic labeling, subsequent CD45 positive cells. A number relevant variables are quantified, or attempted to be which control performance process. Six different labeling combinations were evaluated as well significant difference with respect source: buffy coats purchased from Red...
Objectives/Hypothesis Ingestion of button batteries (BB) can rapidly lead to caustic esophageal injury in infants and children, resulting significant morbidity mortality. To identify novel mitigation strategies, we tested common weakly acidic household beverages, viscous liquids, Carafate® for their ability act as protective irrigations until endoscopic removal the BB. Study Design Cadaveric live animal model. Methods Apple juice, orange Gatorade®, POWERADE®, pure honey, maple syrup, were...
Button battery (BB) injuries continue to be a significant source of morbidity and mortality, there is need confirm the mechanism injury for development additional mitigation strategies.Cadaveric piglet esophageal model.Lithium, silver oxide, alkaline, zinc-air BBs were placed in thawed sections cadaveric esophagus, bathed normal saline. Severity gross visual burn, pH, temperature recorded every 30 minutes 6 hours. In other tissue specimens, lithium BB was removed after 24, 36, 48 hours site...
<h3>Importance</h3> Analysis of the American College Surgeons National Surgical Quality Improvement Program (NSQIP) Pediatric demonstrated that highest contribution to composite morbidity in otolaryngology is seen children younger than 2 years undergoing tracheostomy. <h3>Objective</h3> To determine predictive factors for complications following tracheostomy placement patients that, if targeted reduction quality initiatives, might result improved surgical outcomes. <h3>Design, Setting, and...
Objectives: To present and discuss a high-performance negative depletion method for the isolation of circulating tumor cells (CTCs) in blood patients with head neck cancer to determine correlation between presence CTCs early clinical outcome these patients.Design: Prospective follow-up study squamous cell carcinoma (SCCHN) undergoing surgical intervention, who had peripheral examined CTCs. Patients:The population comprised 48 diagnosed as having SCCHN intervention.Intervention: A process...
Epithelial to mesenchymal transition (EMT) has been hypothesized as a mechanism by which cells change phenotype during carcinogenesis, well tumor metastasis. Whether EMT is involved in cancer metastasis specific, practical impact on the field of circulating (CTCs). Since generally accepted definition CTC includes expression epithelial surface markers, such EpCAM, if cell loses its markers (which suggested EMT), it will not be separated and/or identified CTC. We have developed, and previously...
Children who are deaf or hard of hearing (D/HH) at high risk for permanent deficits in language acquisition and downstream effects such as poor academic performance, personal-social maladjustments, emotional difficulties. Identification children born D/HH through newborn screening subsequent timely early intervention can prevent reduce many these adverse consequences. Ongoing surveillance changes thresholds after infancy is also important should be accomplished by subjective assessment signs...
Noise exposure is a major cause of hearing loss in adults. Yet, noise affects people all ages, and noise-induced also problem for young people. Sensorineural caused by other toxic exposures usually irreversible. Environmental noise, such as traffic can affect learning, physiologic parameters, quality life. Children adolescents have unique vulnerabilities to noise. may be exposed beginning NICUs well-baby nurseries, at home, school, their neighborhoods, recreational settings. Personal...
To investigate the effects of nasal continuous positive airway pressure (CPAP) and cannula use in neonatal intensive care unit.Cross-sectional study.Tertiary children's hospital.One hundred patients (200 cavities), younger than 1 year, who received at least 7 days CPAP (n = 91) or supplementation 9) unit.External examination anterior endoscopy with photographic documentation.The incidence characteristics internal external findings use.Nasal complications were seen 12 91 (13.2%) exposure,...
A completely negative enrichment technology was used to detect circulating tumor cells, CTCs, in the peripheral blood of head and neck cancer patients. Of 32 samples, 63% contained CTCs number identified per mL collected ranged from 0 214. The final purity 1 CTC 9 total cells 20,000 being both a function performance specific enrichment. Consistent with previous reports, were positively if: (1) they nucleus based on DAPI stain, (2) stained positive for cytokeratins, (3) have high nuclei...
IMPORTANCE Despite increased emphasis on measuring safety outcomes and quality indicators for surgical care, little is known regarding which operative procedures should be prioritized quality-improvement initiatives in pediatric otolaryngology.OBJECTIVE To describe the 30-day adverse event rates relative contributions to morbidity otolaryngology surgery using data from American College of Surgeons' National Surgical Quality Improvement Program Pediatric database (ACS-NSQIP-P).DESIGN,...
Objectives/Hypothesis Otitis media is a common problem in the pediatric population. Despite antibiotic therapy, post‐tympanostomy otorrhea can be difficult to treat. Biofilms have been shown play role chronic and recurrent otitis are implicated otorrhea. This study investigated both microbial composition presence of biofilm fragments rich extracellular DNA (eDNA) bacterial DNA‐binding protein, integration host factor (IHF), tube Study Design Clinical samples. Methods Institutional review...
Summary Background Polysomnography ( PSG ) remains the gold standard for diagnosing obstructive sleep apnea OSA and sleep‐disordered breathing in children. Yet, simple screening tools are needed as it is not feasible to perform all patients with possible . Aim The study adapted questions from Pediatric Sleep Questionnaire‐Sleep‐Related Breathing Disorder (SRBD) Questionnaire develop a predictive scale identified on We also tested whether adding anthropometric measurements (body mass index...
ABSTRACT Despite ongoing efforts of the national Button Battery Task Force (BBTF), cases major morbidity and mortality continue to be reported at a higher rate after ingestion voltage larger button batteries. Initiation sucralfate or honey shortly some battery ingestions is crucial prevent further injury while awaiting emergent removal. Endoscopic acetic acid irrigation post removal may halt deeper injury. Gastroenterologists need aware updates National Capital Poison Center algorithm for ingestion.
BackgroundPrior to COVID-19, the use of telemedicine within pediatric surgery was uncommon. To curb spread virus many institutions restricted non-emergent clinic appointments, resulting in an increase use. We examined value for patients presenting a before and after COVID-19MethodsPerspectives potential were assessed by surveying or caregivers being evaluated general surgeon in-person prior COVID-19 who completed appointment with surgical provider during period.ResultsThe pre-COVID survey 57...
Objective: To assess the efficacy of upper airway surgical intervention in patients with Prader-Willi syndrome (PWS).Due to reports sudden death children undergoing treatment growth hormone for PWS, detection sleep-disordered breathing by polysomnography (PSG) has been recommended.Design: Retrospective study.Setting: Multidisciplinary PWS Center at a tertiary care children's hospital.Patients: Thirteen pediatric who underwent adenotonsillectomy (T&A) pre-PSG and post-PSG. Main Outcome...
Over the past few years, there has been a change in clinical practice with transition to use of cuffed instead uncuffed endotracheal tubes (ETTs) pediatric patients. These changes have led concerns regarding unsafe intracuff pressures patients, which may result postoperative morbidity. To avoid these issues, it is generally suggested that pressure be maintained at ≤30 cmH2 O. The current study prospectively assesses related alterations head and neck position patients.Patients less than 18...
To evaluate the characteristics and outcomes of pediatric cochlear implant recipients diagnosed with Usher syndrome (US).Retrospective study consecutive (1991-2010).Tertiary care children's hospital.Children who received a were US either before or after implantation.Electroretinography ophthalmologic findings, anatomy based on preoperative imaging, age independent ambulation, at implantation, speech perception level, communication method.Approximately 26 (3.7%) 712 results...