A5031136904- Congenital gastrointestinal and neural anomalies
- Histone Deacetylase Inhibitors Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pelvic floor disorders treatments
- Intestinal Malrotation and Obstruction Disorders
- Esophageal and GI Pathology
- Congenital Anomalies and Fetal Surgery
- Trauma and Emergency Care Studies
- Anorectal Disease Treatments and Outcomes
- Hernia repair and management
- Cardiac Arrest and Resuscitation
- Gastrointestinal motility and disorders
- COVID-19 and healthcare impacts
- Pharmacological Effects and Toxicity Studies
- Gastrointestinal disorders and treatments
- Telemedicine and Telehealth Implementation
- Mechanical Circulatory Support Devices
- Pain Management and Opioid Use
- Appendicitis Diagnosis and Management
- Child Nutrition and Feeding Issues
- Ultrasound in Clinical Applications
- Trauma Management and Diagnosis
- Apelin-related biomedical research
- Adenosine and Purinergic Signaling
Nationwide Children's Hospital
2021-2025
The Ohio State University
2023-2025
University of Michigan
2013-2020
C. S. Mott Children's Hospital
2013-2020
Michigan Medicine
2013-2019
Michigan United
2015-2019
Copenhagen University Hospital
2015-2017
Rigshospitalet
2015-2017
University of Copenhagen
2016-2017
Case Western Reserve University
2008-2012
Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) remains a leading cause of preventable death worldwide. Mesenchymal stem cell-derived exosomes have demonstrated promise in small animal models neurologic injury. To investigate the effects exosome treatment clinically realistic large model, Yorkshire swine underwent TBI HS. Animals were maintained for 2 h before resuscitation with normal saline (NS). then resuscitated either NS (3 × volume shed blood) or same delayed...
Traumatic brain injury (TBI) and hemorrhagic shock (HS) can be associated with coagulopathy inflammation, but the mechanisms are poorly understood. We hypothesized that a combination of TBI HS would disturb coagulation, damage endothelium, activate inflammatory complement systems.A total 33 swine were allocated to either + (n = 27, volume-controlled 40% blood loss) or controls 6, anesthesia instrumentation). animals left hypotensive (mean arterial pressure, 30-35 mm Hg) for 2 hours. Blood...
BACKGROUND We recently demonstrated that suberoylanilide hydroxamic acid, a broad-spectrum histone deacetylase (HDAC) inhibitor inhibits HDACs 1, 2, 3, and 6, improves survival in mouse model of cecal ligation puncture (CLP)–induced lethal sepsis. The current study was undertaken to determine the effect selective inhibition HDAC isoform on survival, key cytokine production, organ injury, bacteria clearance, cell apoptosis. METHODS In Experiment C57BL/6J mice were subjected CLP and, 1 hour...
BACKGROUND Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) is highly lethal. In a nonsurvival model of TBI + HS, addition high-dose valproic acid (VPA) (300 mg/kg) to hetastarch reduced lesion size associated swelling 6 hours after injury; whether this would have translated into better neurologic outcomes remains unknown. It also unclear lower doses VPA be neuroprotective. We hypothesized that low-dose normal saline (NS) resuscitation result in improved long-term recovery...
Centrifugal pumps are increasingly used for extracorporeal membrane oxygenation (ECMO) rather than roller pumps. However, shear forces induced by these types of continuousflow associated with acquired von Willebrand factor deficiency and bleeding complications. This study was undertaken to compare adverse complications the use centrifugal in patients on prolonged ECMO support. The records all adult from June 2002 2013 were retrospectively reviewed using University Michigan Health System...
Abstract The use of VAD s as a BTT in children with heart failure has increased due to enhanced device design and reliability, leading improved survival, functional capacity, quality life. However, the patients Fontan physiology is rare few case reports. Here, we describe implantation Berlin for 179 days, one longest reported periods mechanical support, child failing single ventricle.
BackgroundMany patients with anorectal malformations (ARM) need a bowel management program (BMP) to manage lifelong problems of fecal incontinence or severe constipation. We aimed evaluate the sustainability results in such program.MethodsA single-institution retrospective review was performed children ARM who attended our BMP (2015–2019). Standardized definitions and validated tools were used assess continence (Baylor Continence Scale), constipation (Cleveland Constipation Scoring System),...
BackgroundPrior to COVID-19, the use of telemedicine within pediatric surgery was uncommon. To curb spread virus many institutions restricted non-emergent clinic appointments, resulting in an increase use. We examined value for patients presenting a before and after COVID-19MethodsPerspectives potential were assessed by surveying or caregivers being evaluated general surgeon in-person prior COVID-19 who completed appointment with surgical provider during period.ResultsThe pre-COVID survey 57...
We have shown previously that fresh frozen plasma (FFP) and lyophilized (LP) decrease brain lesion size improve neurological recovery in a swine model of traumatic injury (TBI) hemorrhagic shock (HS). In this study, we examine whether these findings can be validated clinically relevant severe TBI, HS, polytrauma. Female Yorkshire were subjected to TBI (controlled cortical impact), hemorrhage (40% volume), grade III liver splenic injuries, rib fracture, rectus abdominis crush. The animals...
Objectives: Hemorrhagic shock (HS) can initiate an exaggerated systemic inflammatory response and multiple organ failure, especially if followed by a subsequent insult ("second hit"). We have recently shown that histone deacetylase inhibitors improve survival in rodent models of HS or septic shock, individually. In the present study, we examined whether valproic acid (VPA), inhibitor, could prolong "two-hit" model: from cecal ligation puncture (CLP). Methods: Male Sprague-Dawley rats...
High doses of the histone deacetylase inhibitor valproic acid (VPA, 150-400 mg/kg) improve outcomes in animal models lethal insults. We are conducting a US Food and Drug Administration-approved Phase I, double-blind, placebo-controlled trial to evaluate safety tolerability ascending VPA human volunteers. hypothesized that would induce significant changes proteome healthy humans when given at lower than those used prior studies.Peripheral blood mononuclear cells were obtained from three...