A5034990173- Cutaneous Melanoma Detection and Management
- Hidradenitis Suppurativa and Treatments
- Colorectal and Anal Carcinomas
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Anorectal Disease Treatments and Outcomes
- Cancer-related molecular mechanisms research
- Melanoma and MAPK Pathways
- Plant and Fungal Interactions Research
- Chemotherapy-related skin toxicity
- AI in cancer detection
- CAR-T cell therapy research
- Infectious Diseases and Mycology
- Cell Image Analysis Techniques
- Cancer Genomics and Diagnostics
- Microscopic Colitis
- MicroRNA in disease regulation
- Parvovirus B19 Infection Studies
- Autoimmune Bullous Skin Diseases
- Herpesvirus Infections and Treatments
- Acne and Rosacea Treatments and Effects
- Dermatological and Skeletal Disorders
- Tumors and Oncological Cases
- Immunotherapy and Immune Responses
- Hedgehog Signaling Pathway Studies
Karolinska Institutet
2016-2025
Karolinska University Hospital
2016-2025
Pauls Stradiņš Clinical University Hospital
2024
Stockholm South General Hospital
2017
Austrian Society of Dermatology and Venereology
2006
Integrated Cardio Metabolic Centre
1993-1996
Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep-seated, inflamed lesions in apocrine gland-bearing areas body, most commonly axillae, inguinal and anogenital regions. A mean incidence 6.0 per 100,000 person-years an average prevalence 1% has been reported Europe. HS highest impact on patients' quality life among all assessed dermatological diseases....
Hidradenitis suppurativa (HS) is a long-standing disease with abscess and often fistula formation, predominantly in the axillae groins. The difficult to treat has severe impact on quality of life. A clinically relevant system for scoring severity lacking HS.To evaluate modified Suppurativa Score (HSS) study body mass index (BMI) smoking habits severity.Two hundred fifty-one consecutive patients HS referred clinic special interest were included, whom 115 scored. Points given regions involved,...
Convolutional neural networks (CNNs) achieve expert-level accuracy in the diagnosis of pigmented melanocytic lesions. However, most common types skin cancer are nonpigmented and nonmelanocytic, more difficult to diagnose.To compare a CNN-based classifier with that physicians different levels experience.A classification model was trained on 7895 dermoscopic 5829 close-up images lesions excised at primary clinic between January 1, 2008, July 13, 2017, for combined evaluation both imaging...
Abstract Background Desmoplastic melanoma (DM) is a rare subtype, accounting for less than 5% of primary cutaneous invasive melanomas. DM often arises in chronically sun‐exposed skin, older individuals. While the incidence has increased globally, trends specific to are documented and studies on survival outcomes inconsistent. Objectives To study patient tumour characteristics, desmoplastic comparison with other subtypes using data from population‐based Swedish Melanoma Registry (SweMR)....
The objective of our study was to evaluate a surgical method management patients with hidradentitis suppurativa (HS), using CO2 laser technique for stepwise horizontal vaporization and peroperative monitoring the removal diseased tissue. Twenty-four were selected treatment, 21 women three men, who had suffered from HS mean 13 years (range 1–28 years) experienced more than recurrences suppurating lesions during year prior entering study. follow-up time after surgery 27 months 15–47 months),...
Previous studies have shown different bacteria in hidradenitis suppurativa (HS) lesions, but the literature regarding acute exacerbation of HS is sparse.To determine type isolated from lesions during exacerbations disease.Patients with nodules or abscesses were examined and treated by carbon dioxide laser vaporization. Bacterial samples for aerobic anaerobic cultures taken skin surface (before surgery) then deeper layers (during lesions. At each level two taken, one a punch biopsy pressing...
The introduction of unclassified new psychoactive substances (NPS) on the recreational drugs market through open online sale ('legal highs' or 'Internet drugs') continues unabated and represents a growing health hazard. use NPS has resulted in numerous, severe, adverse events fatalities, due to unintended overdose unknown toxic side‐effects. To try find possible common underlying cause for skin–hair–eye symptoms complex observed three men. From late 2013 mid‐2014, Swedish men aged 23–34...
Abstract Cutaneous Squamous Cell Carcinoma (cSCC) is the most common and fastest-increasing cancer with metastatic potential. Long non-coding RNAs (lncRNAs) circular (circRNAs) are novel regulators of gene expression. To identify mRNAs, lncRNAs circRNAs, which can be involved in cSCC, RNA-seq was performed on nine cSCCs seven healthy skin samples. Representative transcripts were validated by NanoString nCounter assays using an extended cohort, also included samples from pre-cancerous lesions...
Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with high body mass index (BMI) low BMI to investigate differences in disease characteristics. Patients were recruited from 17 dermatological centres four continents. A total of 246 below 25 compared 205 above 35. suffered more severe (Hurley, physician global assessment, number areas affected and patient-reported severity (PRS), P < 0.001 all). There was no...
Background Hidradenitis suppurativa (HS) is a chronic recurrent disease with scars and sinus tract formation that causes substantial impact on quality of life. For evaluation HS treatment results, scoring system for severity (Hidradenitis Suppurativa Score, HSS) has been proposed. Objectives To describe the interobserver reliability HSS further to document its correlation risk factors other measures severity. Methods Sixty-one consecutive patients HS, referred clinical centre special...
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer and a leading cause of mortality among solid organ transplant recipients. MicroRNAs (miR) are short RNAs that regulate gene expression cellular functions. Here, we show negative correlation between miR-203 differentiation grade cSCC. Functionally, suppressed proliferation, motility, angiogenesis-inducing capacity cSCC cells in vitro reduced xenograft tumor volume angiogenesis vivo. Transcriptomic analysis with ectopic...
Both patient survival and the proportion of patients diagnosed with thin cutaneous malignant melanoma (CMM) have been steadily rising in Sweden as most Western countries, although rate improvement appears to declined at end last millennium.To analyse recent trends distribution tumour thickness (T category) well CMM-specific Swedish during 1997-2011.This nationwide population-based study included 30,590 registered Melanoma Register (SMR) a first primary invasive CMM 1997-2011. The were...
Background: Teledermoscopy (TDS) emerges as an efficient tool for diagnosing skin lesions. In Sweden, double reading is the standard of care, but risk factors misdiagnosis or mismanagement using single reader evaluations (SRE) are not well-studied. This study aimed to assess accuracy SRE compared with gold in TDS. Methods: retrospective cohort involved 1,997 TDS referrals sent from general practitioners dermatologists Stockholm, selected based on dermoscopic diagnoses. All underwent (DRE)....
Over the past decades, many regions have experienced a steady increase in incidence of cutaneous melanoma. Here, we report on trends for subsequent primary melanoma.In this nationwide population-based study, patients diagnosed with first melanoma reported to Swedish Cancer Registry were followed up 10 years diagnosis Patients grouped same decade (1960s, 1970s, 1980s, 1990s, and 2000s, respectively). Frequencies, rates (IRs), standardized ratios (SIRs), 95% confidence intervals (CIs) second...
Abstract Background Melanoma-specific survival (MSS) is heterogenous between stages and highly dependent on the T stage for primary localized disease. New systemic therapies metastatic cutaneous melanoma (CM) have been introduced since 2012 in Sweden. Objectives To analyse incidence MSS time trends 1990 2020 Methods Nationwide, population-based prospectively collected clinico-pathological data invasive CM from Swedish Melanoma Registry (SweMR) were analysed using Kaplan–Meier curves Cox...