A5040854623- Cutaneous Melanoma Detection and Management
- Microbial Inactivation Methods
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Skin Protection and Aging
- Melanoma and MAPK Pathways
- melanin and skin pigmentation
- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Psoriasis: Treatment and Pathogenesis
- Acne and Rosacea Treatments and Effects
- Chemotherapy-related skin toxicity
- Cancer and Skin Lesions
- Electrostatic Discharge in Electronics
- Genetic and rare skin diseases.
- Photodynamic Therapy Research Studies
- Histiocytic Disorders and Treatments
- Cell Image Analysis Techniques
- Autoimmune Bullous Skin Diseases
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Microfluidic and Bio-sensing Technologies
- Medicine and Dermatology Studies History
- Allergic Rhinitis and Sensitization
University of Szeged
2014-2025
University of Debrecen
2016
Galderma (France)
2007
Hungarian Academy of Sciences
2001
Few studies have evaluated differences between rosacea subtypes in epidemiological associations and clinical features. The natural history of is unknown progression has been implied but not formally evaluated.To assess the four [erythematotelangiectatic (ETR), papulopustular (PPR), phymatous (PHY) ocular], including quantitative qualitative details on primary secondary features rosacea. A objective was to evaluate for potential subtypes.This cross-sectional study recruited subjects with from...
Abstract Cutaneous Squamous Cell Carcinoma (cSCC) is the most common and fastest-increasing cancer with metastatic potential. Long non-coding RNAs (lncRNAs) circular (circRNAs) are novel regulators of gene expression. To identify mRNAs, lncRNAs circRNAs, which can be involved in cSCC, RNA-seq was performed on nine cSCCs seven healthy skin samples. Representative transcripts were validated by NanoString nCounter assays using an extended cohort, also included samples from pre-cancerous lesions...
Calcium electroporation (Ca-EP) is a new anticancer treatment providing similar features to electrochemotherapy (ECT). The aim of our study compare the efficacy Ca-EP with bleomycin-based ECT. This double-blinded randomized controlled phase II was conducted at Medical University Szeged, Hungary. During this once only up ten measurable cutaneous metastases per patient were separately block for intratumoral delivery either calcium or bleomycin, which followed by reversible electroporation....
Abstract Background Narrow‐band ultraviolet B phototherapy is an effictive and safe treatment for atopic dermatitis. We have previously found that the 308 nm xenon chloride excimer laser was more effective than narrow‐band light of psoriasis, suggesting might offer advantages over B. Objective The purpose this study to evaluate therapeutic efficacy in Patients methods Fifteen patients with dermatitis (less 20% body area involvement) were treated a (XTRAC laser, Photomedex Inc.) twice weekly....
Gorlin-Goltz syndrome is a rare multisystemic disease, characterized by numerous basal cell carcinomas. The ideal approach for patients with the would be treatment high cure rate, minimal scarring, short healing time and mild side-effects. Electrochemo-therapy novel therapeutic option that ablates tumours electrical current simultaneously administered anticancer drugs. Three were treated electrochemotherapy using intravenous bleomycin. Clinical response was obtained in 98 (99%) of lesions,...
Abstract There is increasing evidence about the effectiveness of electrochemotherapy (ECT) in treatment basal cell carcinomas head and neck region, although its role management eyelid-periocular skin tumors has to be clarified. The aim present study evaluate results ECT locally advanced primary recurrent carcinomas. Twelve patients with carcinoma involving region were treated ECT. Three had tumors, while 9 tumors. All treatments performed according ESOPE guidelines, using Cliniporator TM...
Introduction: Immunosuppressed patients face a significantly higher risk of developing malignant skin tumors compared to the general population, often presenting with numerous, rapidly growing, and aggressive lesions. It can be particularly challenging treat these tumors, especially in head neck region. Electrochemotherapy (ECT) emerges as viable option for treating multiple simultaneously. This study aims compare efficacy, toxicity, impacts on quality life ECT nonmelanoma cancers (NMSCs)...
<title>Abstract</title> Background The rising prevalence of cutaneous and subcutaneous tumors has driven interest in electrochemotherapy (ECT) as a potential treatment. However, patient-reported outcomes remain underexplored. Objectives This study aims to assess the impact ECT on quality life (QoL) patients, addressing gap current literature. Methods A prospective evaluated 62 patients treated with between 2015 2022. QoL was measured using EQ-5D-3L questionnaire, calculating EQ-5D-index...
Lentigo maligna (LM), lentigo melanoma (LMM), and acral lentiginous (ALM) are characterized by irregular borders manifest on highly visible and/or surgically challenging areas. The challenge in treating these melanomas lies preserving function achieving satisfactory esthetic outcomes while ensuring complete surgical excision with an appropriate safety margin. We report three cases of elderly patients LM, LMM, ALM treated electrochemotherapy (ECT). All were according to the European Standard...
Abstract The rising prevalence of cutaneous and subcutaneous tumors has driven interest in electrochemotherapy (ECT) as a potential treatment. However, patient-reported outcomes remain underexplored. This study aims to assess the short-term impact ECT on quality life (QoL) patients, addressing gap current literature. A prospective evaluated 62 patients treated with between 2015 2022. QoL was measured using EQ-5D-3L questionnaire, calculating EQ-5D-index assessing health state (EQ-VAS) pain...
Early melanoma detection strategies include skin self-examination (SSE), physician examination (PSE), and promotion of patient knowledge about cancer.To investigate the association SSE, PSE, attitudes with thinner superficial spreading (SSM) nodular (NM), latter which tends to elude early detection.This cross-sectional, questionnaire-based, multicenter study identified patients newly diagnosed cutaneous at 4 referral hospital centers in United States, Greece, Hungary. Among 920 a primary...
Introduction: Rosacea is a common and chronic disorder characterized by flushing, erythema, papules, pustules, telangiectasia on the central part of face. Because facial skin individuals with rosacea particularly sensitive, irritants can trigger worsening signs symptoms disease. This enhanced sensitivity thought to be linked deficient stratum corneum barrier function. Materials methods: In present study, 20 receiving twice‐daily applications metronidazole 0.75% gel for at least 15 days...
Abstract Background Langerhans cell histiocytosis (LCH) is characterized by the proliferation of pathologic cells. The disease can develop in any age and affect almost organ. Cutaneous involvement frequent LCH. recent demonstration activating, oncogenic BRAFV600E gene mutation LCH samples strongly supports neoplastic origin disease. Objectives Our aim was to analyse clinical data patients whether present skin lesions with adult onset LCH, investigate status has effect on presentation outcome...
Abstract Sentinel lymph node biopsy (SLNB) is a standard procedure for regional staging and still has the most important prognostic value outcome of patients with thin melanoma. In addition to ulceration, SLNB had be considered even single mitotic figure in (<1 mm) melanoma according AJCC7th guideline, therefore, retrospective review was conducted involving 403 pT1 patients. Among them, 152 suffered from pT1b ulcerated or rate ≥ 1/ mm 2 melanomas system. performed 78 cases, which nine...
Abstract Background While electrochemotherapy (ECT) is increasingly utilized as a highly effective method in the treatment of tumors head and neck region, there significantly less data available for eyelid‐periocular skin tumors. Our group reported first extensive case series basal cell carcinoma (BCC) patients with short‐term follow‐up ECT. The present study aims to report our long‐term results BCC cases treated Methods treatments were performed according ESOPE (European Standard Operating...
Abstract Background Acral lentiginous melanoma ( ALM ) occurs on the palms, soles and subungual surface has poor prognosis. It is uncommon in Caucasian population remained unreported East‐Central Europe. Objectives Our aim was to collect data from Europe by analysing demographic clinicopathologic features of patients with comparing reports literature. Methods We conducted a single‐centre, retrospective review between 1976 2016 at one largest referral centres Hungary. Results identified 176...
Abstract Melanocortin‐1 receptor (MC1R) and agouti signaling protein (ASIP) play pivotal roles in the regulation of human pigmentation. We aimed to study whether single nucleotide polymorphisms (SNPs) MC1R ASIP genes contribute pathogenesis polygenic pigment skin disorder, vitiligo. The PCR‐amplified, full‐length gene was studied with sequence analysis, 3′ untranslated region (3′ UTR) SNP detected using restriction fragment length polymorphism. allele frequency did not show any difference...