The major limitations of widespread use non-intubated thoracic surgery (NITS) is the fear managing complications. Here we present our practice converting from uniportal video-assisted (VATS) NITS to open in cases surgical complications.The study period was January 26, 2017, November 30, 2018. Total intravenous anesthesia provided with propofol guided by bispectral index, and airway maintained a laryngeal mask spontaneous breathing. Local 2% lidocaine at skin incision, intercostal vagus nerve...

Minimally invasive thoracic surgery is the most frequently used approach for lung resection to minimize surgical stress on patient. To further reduce invasiveness, non-intubated spontaneous ventilation method applied anesthesia side. However, due unsafe airway associated with this procedure, not widely adopted. This study analyzes results of our method, which involves double lumen tube intubation and uniportal video-assisted (VATS) lobectomies. Between 2015 2023, 302 patients underwent VATS...

<title>Abstract</title> Background The rising prevalence of cutaneous and subcutaneous tumors has driven interest in electrochemotherapy (ECT) as a potential treatment. However, patient-reported outcomes remain underexplored. Objectives This study aims to assess the impact ECT on quality life (QoL) patients, addressing gap current literature. Methods A prospective evaluated 62 patients treated with between 2015 2022. QoL was measured using EQ-5D-3L questionnaire, calculating EQ-5D-index...

Abstract The rising prevalence of cutaneous and subcutaneous tumors has driven interest in electrochemotherapy (ECT) as a potential treatment. However, patient-reported outcomes remain underexplored. This study aims to assess the short-term impact ECT on quality life (QoL) patients, addressing gap current literature. A prospective evaluated 62 patients treated with between 2015 2022. QoL was measured using EQ-5D-3L questionnaire, calculating EQ-5D-index assessing health state (EQ-VAS) pain...

Prone positioning has been found feasible and appropriate for the reduction of radiation exposure lungs, but its effects on heart dose remain controversial. Individual anatomical features were sought selection optimal treatment positioning.In 138 left-sided breast cancer cases awaiting postoperative whole-breast radiotherapy, conformal radiotherapy plans generated in both prone supine positions.The doses to left anterior descending coronary artery (LAD) two positions differed individually,...

IntroductionDeep-inspirational breath hold (DIBH) is an option for heart protection in breast radiotherapy; we intended to study its individual benefit.Materials and Methods3DCRT treatment planning was performed a cohort of 103 patients receiving radiotherapy the whole (WBI)/chest wall (CWI) ± nodal regions (NI) both under DIBH free breathing (FB) supine position, WBI only cases prone (n = 45) too. A series patient-related dosimetry parameters were analyzed.ResultsThe technique provided...

Objective. The aim of our study was to conduct a retrospective investigation the efficacy laparoscopic Nissen fundoplication in patients with Barrett's esophagus. Material and methods. A total 78 esophagus underwent surgery. Patients were divided into three groups on basis preoperative endoscopic biopsies: non-intestinal group (n = 63) fundic or cardiac metaplasia, an intestinal 18) dysplastic 7) low-grade dysplasia. Clinical follow-up available case 64 at mean 42 ± 16.9 months after...

The hazard caused by driving under the influence of drugs (DUID) is determined time consumption, dose and biological effects a substance, as well synergistic drug interactions after multi-drug use. aim this work was to investigate prevalence pattern psychoactive substance use suspected DUID drivers present advantages disadvantages system currently used for determination impairment in Hungary. Blood urine samples, collected between 2016 2018, were taken from 2369 with positivity rate 95% at...

Predicting lethal arrhythmia liability from beat-to-beat variability and instability (BVI) of the ECG intervals is a useful technique in drug assessment. Most investigators use only arrhythmia-free ECGs for this. Recently, it was shown that drug-induced torsades de pointes (TdP) can be predicted more accurately BVI measured irrespective rhythm, even during arrhythmias (absolute BVI). The present study tested broader applicability this assessment by examining whether absolute parameters...

Purpose: The role of cystic fibrosis transmembrane conductance regulator (CFTR) in lacrimal gland (LG) function has only recently received some attention, mainly from our group. In the present study, we investigated potential changes LG pathology, tear secretion, ocular surface integrity, and fluid secretion isolated ducts CFTR knockout (KO) mice. Methods: Tear production integrity were anesthetized wild-type (WT) KO mice using cotton threads fluorescein staining, respectively....

A higher rate of embolization is considered a disadvantage carotid stenting (CAS), when compared with endarterectomy. Plaques in the aortic arch (AA) and common artery (CCA) may be additional sources to stented internal plaques during CAS. In this study, we aimed investigate relationship between these intracerebral embolization.We analyzed occurrence composition AA CCA by computed tomography angiography (CTA) 101 consecutive cases Cases peri-procedural were detected on diffusion-weighted...

Although the mechanical status of lungs affects shape capnogram, relations between capnographic parameters and those reflecting airway lung tissue mechanics have not been established in mechanically ventilated patients. We, therefore, set out to characterize how properties airways tissues modify indices obtained from different phases time volumetric capnograms changes are reflected altered after a cardiopulmonary bypass (CPB).Anesthetized, patients (n = 101) undergoing heart surgery were...

Patients undergoing thoracic surgery are at increased risk of developing, long-lasting pain. Beyond the non-surgical factors, type operation, including number incisions, and anesthetic assessment seemed to be important although some studies controversial. The aim our study was examine presence chronic postoperative pain after non-intubated uniportal VATS lobectomy. We examined difference between intubated, relaxed spontaneous ventilation surgical approaches in patients who underwent...

Bevezetés: A minimálinvazív műtéti technika a mellkassebészetben, tüdődaganatok ellátása kapcsán előtérbe került az elmúlt évtizedekben, melynek egyik kiemelkedő részét alkotják spontán légzés mellett elvégzett mellkassebészeti műtétek. Célkitűzés: Jelen közleményünkben nem intubált és relaxált videoasszisztált torakoszkópos (I. csoport) (II. tüdőlebeny-eltávolítások eredményeit hasonlítottuk össze. Módszer: Az I. csoportban 118, míg II. 211, uniportalis tüdőlebeny-eltávolításon átesett...

The spectrum of neurodevelopmental disabilities was studied in a cohort patients Hungary. A search for etiologies and assessment the degree intellectual disability were carried out. study included 241 (131 boys) patients. Disability occurred without any prenatal, perinatal, and/or neonatal adverse events 167 They classified into following subgroups: genetic syndromes with recognized etiology, global developmental delay/intellectual association dysmorphic features but unknown brain...

We recently reported that isolated duct segments from rabbit lacrimal gland (LG) were able to secrete fluid in response secretagogues, which blocked completely by bumetanide. This suggests the functional involvement of Na+-K+-2Cl- cotransporter (NKCC1) ductal secretion. Therefore, aim this study was investigate activity profile NKCC1 LG segments.Interlobular ducts fresh tissue. Microfluorometry with ammonium (NH4+)-pulse technique used elicit pH changes cells, and rate bumetanide-sensitive...

Background Cytarabine (cytosine arabinoside, ara-C) is a chemotherapeutical agent used in the treatment of pediatric acute lymphoblastic leukemia (ALL). Adverse drug reactions, such as interpatient variability sensitivity to ara-C, are considerable and may cause difficulties during chemotherapy. Single nucleotide polymorphisms (SNPs) can play significant role modifying nucleoside-drug pharmacokinetics pharmacodynamics thus development adverse effects. Our aim was determine whether genes...