A5022123648- Spinal Cord Injury Research
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Mesenchymal stem cell research
- Stroke Rehabilitation and Recovery
- Cardiac Ischemia and Reperfusion
- Ocular Surface and Contact Lens
- RNA Interference and Gene Delivery
- Plant Physiology and Cultivation Studies
- Pluripotent Stem Cells Research
- Spine and Intervertebral Disc Pathology
- Virus-based gene therapy research
- Salivary Gland Disorders and Functions
- Nitric Oxide and Endothelin Effects
- Ion Transport and Channel Regulation
- Olfactory and Sensory Function Studies
- Tissue Engineering and Regenerative Medicine
- Erythrocyte Function and Pathophysiology
- Muscle activation and electromyography studies
- Nerve Injury and Rehabilitation
- Peripheral Nerve Disorders
University of Szeged
2017-2025
Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment an injured spinal cord and promote neuroprotection functional recovery is a great challenge. Nucleoside-modified messenger RNA (mRNA) has become promising new modality that can be utilized for safe efficient therapeutic proteins. Here, we used lipid nanoparticle (LNP)-encapsulated human interleukin-10 (hIL-10)-encoding nucleoside-modified mRNA induce following rat contusion injury. Intralesional...
Abstract Spinal cord injury results in irreversible tissue damage followed by a very limited recovery of function. In this study we investigated whether transplantation undifferentiated human induced pluripotent stem cells (hiPSCs) into the injured rat spinal is able to induce morphological and functional improvement. hiPSCs were grafted intraspinally or intravenously one week after thoracic (T11) contusion performed Fischer 344 rats. Grafted animals showed significantly better than control...
Ventral root avulsion induces dramatic loss of the affected spinal cord motoneurons. The neuroprotective effect riluzole has been previously proven on injured motoneurons: vast majority them can be rescued even when they have no possibility to regenerate their axons. In this study number motoneurons by treatment and capacity reinnervate denervated forelimb muscles was investigated. Surgical reconnection with a peripheral nerve graft between segment C7 established immediately or 1- 3-week...
Purpose: The role of cystic fibrosis transmembrane conductance regulator (CFTR) in lacrimal gland (LG) function has only recently received some attention, mainly from our group. In the present study, we investigated potential changes LG pathology, tear secretion, ocular surface integrity, and fluid secretion isolated ducts CFTR knockout (KO) mice. Methods: Tear production integrity were anesthetized wild-type (WT) KO mice using cotton threads fluorescein staining, respectively....
Purpose: Earlier reports highlighted the predominant presence of aquaporin 4 (AQP4) in duct cells rabbit lacrimal glands (LGs). Whereas significant alterations AQP4 mRNA levels have been observed experimental dry eye and during pregnancy, impact LG ductal fluid production remains unclear. In our recent work, role secretion was investigated utilizing wild type (WT) knock out (KO) mice. Methods: Tear assessed both WT KO animals. Immunostaining used to identify protein. Duct segments were...
Spinal cord injuries induce a critical loss of motoneurons followed by irreversible locomotor function impairment. Surgical approaches combined with neuroprotective agents effectively rescue the damaged and improve function. Our aim was to develop reliable method which is able provide quantifiable in-depth data on recovery during skeletal muscle reinnervation. Sprague-Dawley rats underwent lumbar 4 ventral root avulsion reimplantation riluzole treatment in order injured pool. Control animals...