A5060730893- Neural dynamics and brain function
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Cardiovascular Health and Disease Prevention
- Multisensory perception and integration
- Visual perception and processing mechanisms
- Neural Networks and Applications
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Neuroscience of respiration and sleep
- Dialysis and Renal Disease Management
- Respiratory Support and Mechanisms
- Tactile and Sensory Interactions
- Olfactory and Sensory Function Studies
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neural Engineering
- Cerebrovascular and Carotid Artery Diseases
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- Electrolyte and hormonal disorders
- Neurosurgical Procedures and Complications
- Renal function and acid-base balance
University of Bologna
2016-2025
Italian Medicines Agency
2025
Laboratori Guglielmo Marconi (Italy)
2013-2024
Marconi University
2013-2024
Children's Hospital of Eastern Ontario
2020
University of Ottawa
2020
Inserm
2019
Azienda-Unita' Sanitaria Locale Di Cesena
2019
Centre de Recherche des Cordeliers
2019
Philips (United States)
2015
The aim of this work is to characterize quantitatively the performance a body techniques in frequency domain for estimation cortical connectivity from high-resolution EEG recordings different operative conditions commonly encountered practice. Connectivity pattern estimators investigated are Directed Transfer Function (DTF), its modification known as direct DTF (dDTF) and Partial Coherence (PDC). Predefined patterns were simulated then retrieved by application DTF, dDTF, PDC methods....
A mathematical model of short-term arterial pressure control by the carotid baroreceptors in pulsatile conditions is presented. The includes an elastance variable description left and right heart, systemic (splanchnic extrasplanchnic) pulmonary circulations, afferent baroreceptor pathway, sympathetic vagal efferent activities, action several effector mechanisms. latter mechanisms work, response to action, modifying peripheral resistances, venous unstressed volumes, heart period, end-systolic...
A simple mathematical model of intracranial pressure (ICP) dynamics oriented to clinical practice is presented. It includes the hemodynamics arterial-arteriolar cerebrovascular bed, cerebrospinal fluid (CSF) production and reabsorption processes, nonlinear pressure-volume relationship craniospinal compartment, a Starling resistor mechanism for cerebral veins. Moreover, arterioles are controlled by autoregulation mechanisms, which simulated means time constant sigmoidal static characteristic....
The directed transfer function (DTF) and the partial coherence (PDC) are frequency-domain estimators that able to describe interactions between cortical areas in terms of concept Granger causality. However, classical estimation these methods is based on multivariate autoregressive modelling (MVAR) time series, which requires stationarity signals. In this way, transient pathways information remains hidden. objective study test a time-varying method for rapidly changing connectivity...
Several cardiovascular and pulmonary models have been proposed in the last few decades. However, very addressed interactions between these two systems. Our group has developed an integrated cardiopulmonary model (CP Model) that mathematically describes respiratory systems, along with their main short-term control mechanisms. The compared human animal data taken from published literature. Due to volume of work, paper is divided parts. present on development normophysiology, whereas second...
Variations in alpha rhythm have a significant role perception and attention. Recently, decrease has been associated with externally directed attention, especially the visual domain, whereas increase related to internal processing such as mental arithmetic. However, of oscillations how different components task (processing external stimuli, manipulation/representation, demand) interact affect power are still unclear. Here, we investigate is differently modulated by attentional tasks depending...
Objective - Assessing brain connectivity from electrophysiological signals is of great relevance in neuroscience, but results are still debated and depend crucially on how defined mathematical instruments utilized. Aim this work to assess the capacity bivariate Transfer Entropy (TE) evaluate connectivity, using data generated simple neural mass models connected Regions Interest (ROIs). Approach Signals simulating mean field potentials were assuming two, three or four ROIs, via excitatory...
Abstract Background and Hypothesis Oscillatory synchrony plays a crucial role in establishing functional connectivity across distinct brain regions. Within the realm of schizophrenia, suggested to be neuropsychiatric disconnection syndrome, discernible aberrations arise organization networks. We aim investigate whether resting-state network is already altered healthy individuals with high schizotypy traits, highlighting pivotal influence rhythms driving alterations. Study Design Two-minute...
A mathematical lumped parameter model of the oscillometric technique for indirect blood pressure measurement is presented. The includes cuff compliance, transmission from to brachial artery through soft tissue arm, and biomechanics both at positive negative transmural values. main aspects oscillometry are simulated i.e., increase in pulsatility during deflation maneuvers, existence a point maximum pulsations (about 1.5 mmHg) close mean arterial pressure, characteristic ratios systole...
The relationships among cerebral blood flow, volume, intracranial pressure (ICP), and the action of cerebrovascular regulatory mechanisms (autoregulation CO2 reactivity) were investigated by means a mathematical model. model incorporates cerebrospinal fluid (CSF) circulation, pressure-volume relationship, hemodynamics. latter is based on following main assumptions: middle arteries behave passively transmural changes; pial arterial circulation includes two segments (large small arteries)...
The aim of this paper is to test a technique called partial directed coherence (PDC) and its modification (squared PDC; sPDC) for the estimation human cortical connectivity by means simulation study, in which both PDC sPDC were studied analysis variance. statistical performed returned that are able estimate correctly imposed patterns when data exhibit signal-to-noise ratio at least 3 length 27 s nonconsecutive recordings 250 Hz sampling rate, equivalent, more generally, 6750 samples.
A mathematical model of short-term cardiovascular regulation is used to investigate how heart period variability reflects the action autonomic regulatory mechanisms (vagal and sympathetic). The includes pulsating heart, systemic (splanchnic extrasplanchnic) pulmonary circulation, mechanical effect respiration on venous return, two groups receptors (arterial baroreceptors lung stretch receptors), sympathetic vagal efferent branches, a very low-frequency (LF) vasomotor noise. All parameters...
Attention is the ability to prioritize a set of information at expense others and can be internally- or externally-oriented. Alpha theta oscillations have been extensively implicated in attention. However, it unclear how these operate when sensory distractors are presented continuously during task-relevant internal processes, close-to-real-life conditions. Here, EEG signals from healthy participants were obtained rest three attentional conditions, characterized by execution mental math task...
A mathematical model of the acute cardiovascular response to isocapnic hypoxia is presented. It includes a pulsating heart, systemic and pulmonary circulation, separate description vascular bed in organs with higher metabolic need, local effect O 2 on these organs. Moreover, also action several reflex regulatory mechanisms: peripheral chemoreceptors, lung stretch receptors, arterial baroreceptors, hypoxic central nervous system. All parameters are given accordance physiological literature....
Brain connectivity is often altered in autism spectrum disorder (ASD). However, there little consensus on the nature of these alterations, with studies pointing to either increased or decreased strength across broad spectrum. An important confound interpretation contradictory results lack information about directionality tested connections. Here, we aimed at disambiguating confounds by measuring differences directed using EEG resting-state recordings individuals low and high autistic traits....
Astrocytes are responsible for maintaining homoeostasis and cognitive functions through calcium signalling, a process that is altered in brain diseases. Current bioelectronic tools designed to study neurons not suitable controlling signals astrocytes. Here, we show electrical stimulation of astrocytes using electrodes coated with graphene oxide reduced induces respectively slow response calcium, mediated by external influx, sharp one, exclusively due release from intracellular stores. Our...
Object. The aim of this study was to analyze how the main values extrapolated from transcranial Doppler (TCD) waveform (systolic, mean, and diastolic velocity; velocity peak-to-peak amplitude; pulsatility index [PI]) are affected by changes in intracranial pressure (ICP), systemic arterial (SAP), autoregulation, compliance. Methods. analysis performed using a mathematical model dynamics. This includes passive middle cerebral artery, biomechanics large small pial arteries subjected...