A5084973825- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Retinal Development and Disorders
- Zebrafish Biomedical Research Applications
- Olfactory and Sensory Function Studies
- Single-cell and spatial transcriptomics
- Visual perception and processing mechanisms
- Advanced Memory and Neural Computing
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Advanced Fluorescence Microscopy Techniques
- Virus-based gene therapy research
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
California Institute of Technology
2021-2025
University of California System
2025
University of California, Los Angeles
2025
University of Oregon
2015-2019
Sensory-driven behaviors engage a cascade of cortical regions to process sensory input and generate motor output. To investigate the temporal dynamics neural activity at this global scale, we have improved integrated tools perform functional imaging across large areas cortex using transgenic mouse expressing genetically encoded calcium sensor GCaMP6s, together with head-fixed visual discrimination behavior. This technique allows dorsal surface cortex, spatial resolution adequate detect...
Abstract The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs 1 . Retinal cell types may have evolved to accommodate these varied needs, but this has not been systematically studied. Here we generated and integrated single-cell transcriptomic atlases from 17 species: humans, two non-human primates, four rodents, three ungulates, opossum, ferret, tree shrew, a bird, reptile, teleost fish lamprey. We found high molecular conservation...
The rodent visual system has attracted great interest in recent years due to its experimental tractability, but the fundamental mechanisms used by mouse represent world remain unclear. In primate, researchers have argued from both behavioral and neural evidence that a key step representation is ‘figure-ground segmentation’, delineation of figures as distinct backgrounds. To determine if mice also show signatures figure-ground segmentation, we trained on segmentation task where were defined...
Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research. Existing viral non‐viral methods often suffer from inefficient intracellular access due to endocytic pathway. Here, a neuron‐targeting direct cytosolic platform is discovered by using 15‐amino‐acid peptide, termed N1 which enables neuron‐specific targeting functional biomolecules. The peptide initially binds...
Abstract Learning can cause significant changes in neural responses to relevant stimuli, addition modulation due task engagement. However, it is not known how different functional types of excitatory neurons contribute these changes. To address this gap, we performed two-photon calcium imaging layer 2/3 mouse primary visual cortex before and after learning a discrimination. We found that show striking diversity the temporal dynamics their response stimuli during behavior, based on classified...
Abstract The rodent visual system has attracted great interest in recent years due to its experimental tractability, but the fundamental mechanisms used by mouse represent world remain unclear. In primate, researchers have argued from both behavioral and neural evidence that a key step representation is “figure-ground segmentation,” delineation of figures as distinct backgrounds [1–4]. To determine if mice also show signatures figure-ground segmentation, we trained on segmentation task where...