A5042470942- Synthesis and Biological Evaluation
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Microbial bioremediation and biosurfactants
- Pharmaceutical and Antibiotic Environmental Impacts
- Biochemical and Molecular Research
- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Enzyme function and inhibition
- Phytochemistry and Biological Activities
- Insect Pest Control Strategies
- Synthesis and Reactions of Organic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antibiotic Resistance in Bacteria
- Synthesis and Characterization of Heterocyclic Compounds
- Toxin Mechanisms and Immunotoxins
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Antibiotics Pharmacokinetics and Efficacy
- Toxic Organic Pollutants Impact
- Quinazolinone synthesis and applications
- Psidium guajava Extracts and Applications
- Cancer Mechanisms and Therapy
Instituto Politécnico Nacional
2015-2025
Centro de Ingeniería Genética y Biotecnología
2024
Universidad Autónoma de Nuevo León
2024
is a traditional Mexican medicinal plant and an important source of secondary metabolites with antimicrobial cytotoxic activity. The aim this work was to conduct comparative analysis different roots leaf extracts
Background Stenotrophomonas are ubiquitous gram-negative bacteria, which can survive in a wide range of environments. They use many substances for their growth and known to be intrinsically resistant antimicrobial agents. have been tested biotechnological applications, bioremediation, production Method sp . Pemsol was isolated from crude oil contaminated soil. The capability this isolate tolerate degrade polycyclic aromatic hydrocarbons (PAH) such as anthraquinone, biphenyl, naphthalene,...
Spodoptera frugiperda (S. frugiperda) remains a global primary pest of maize. Therefore, new options to combat this are necessary. In study, the insecticidal activity three crude foliar extracts (ethanol, dichloromethane, and hexane) their main secondary metabolites (quercetin chlorogenic acid) species Solidago graminifolia graminifolia) by ingestion bioassays against S. larvae was analyzed. Additionally, were phytochemically elucidated ultra-performance liquid chromatography-mass...
In this study, n-butyl and iso-butyl quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives were evaluated in vitro against Giardia lamblia (G. lamblia), Trichomonas vaginalis (T. vaginalis), Entamoeba histolytica (E. histolytica). The potential mechanism of action determination was approached by silico analysis on G. T. triosephosphate isomerase (GlTIM TvTIM, respectively), E. thioredoxin reductase (EhTrxR). Enzyme inactivation assays performed recombinant GlTIM EhTrxR. Compound T-167 showed...
Background/Objectives: Pork tapeworm Taenia solium is the causative agent of cysticercosis which may develop in muscle tissue, skin, eyes, and central nervous system (neurocysticercosis). It estimated by World Health Organization (WHO) that about 2.56–8.30 million are infected worldwide. Praziquantel albendazole used for anthelminthic treatment neurocysticercosis; however, not all patients have a complete elimination cysts, makes it necessary to seek new improved options. Methods: In this...
The primary strategy for managing Nacobbus aberrans has traditionally relied on synthetic chemicals. However, increasing regulatory pressure unsafe products led to a growing research focus nematicides. Despite this, chemical nematicides remain more effective than other control methods. Consequently, there is pressing need develop novel that are both and environmentally safer. This study aimed evaluate the nematocidal efficacy of various molecules against second-stage juveniles N. aberrans,...
Background: To date, COVID-19 has caused over 772 million cases, with approximately 7 deaths, according to the World Health Organization. Therefore, there is a need develop new drugs address challenges posed by this disease. Objective: propose antiviral agents based on natural product curcumin as potential protein-protein interaction inhibitors between SARS-CoV-2 spike receptor binding domain (RBD) and ACE2 receptor. Methods: A curcumin-based virtual screening was performed (Tanimoto...
Background/Objectives: α-carbonic anhydrase (α-TcCA) has emerged as a promising drug target in T. cruzi, the causative agent of Chagas disease Americas. Sulfonamides, known inhibitors CAs, bind to zinc ion on enzyme’s active site. This study proposes repositioning sulfonamide-based drugs identify new trypanocidal agents. Method: Ligand-based virtual screening and molecular docking analysis were performed FDA-approved targeting α-TcCA. These compounds evaluated vitro ex vivo against A1 NINOA...
Background/Objectives: Nifuroxazide (Nfz) is a drug that has been used as scaffold for designing antimicrobial and antiparasitic agents. This study aimed to synthesize evaluate in vitro of Nfz twenty-five 4-hydroxybenzhydrazone derivatives potential anti-Trypanosoma cruzi, anti-Leishmania mexicana, anti-Mycobacterium tuberculosis Methods: The compounds were synthesized by condensing 4-hydroxybenzhydrazide with appropriate aldehydes acidic conditions structurally confirmed spectroscopic...
Infectious diseases caused by intestinal protozoan, such as Entamoeba histolytica (E. histolytica) and Giardia lamblia (G. lamblia) are a worldwide public health issue. They affect more than 70 million people every year. colonize intestines causing primarily diarrhea; nevertheless, these infections can lead to serious complications. The treatment of choice, metronidazole, is in doubt due adverse effects resistance. Therefore, there need for new compounds against parasites. In this work,...
American trypanosomiasis is a worldwide health problem that requires attention due to ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives against trypomastigotes of the Trypanosoma cruzi strains NINOA INC-5. An in silico analysis interactions on active site trypanothione reductase (TR) an enzyme inhibition study was carried out. The series compound identified as T-150 had best trypanocidal activity T. trypomastigotes, with 13%...
In this study, the prevalence of Vibrio cholerae, parahaemolyticus, mimicus, vulnificus and spp. in shrimp from retail markets Reynosa, Mexico was determined. A total 765 isolates, identified as (59·1%), V. cholerae (17·8%), mimicus (6·7%) parahaemolyticus (4·6%), were obtained; not detected. Most strains isolated supermarkets (48·1%), followed by street vendors (37·3%) stores (14·6%). Moreover, several virulence genes cholerae: toxR (100%), OmpU (76·5%), hlyA VPI (19·9%) tcpA (5·1%);...
Polycyclic aromatic hydrocarbons (PAHs) are organic compounds generated mainly by anthropogenic sources. They considered toxic to mammals, since they have carcinogenic, mutagenic and genotoxic properties, among others. Although mycoremediation is an efficient, economical eco-friendly technique for degrading PAHs, the fungal degradation potential of phylum Ascomycota has not been widely studied. In this work, we evaluated different strains from polluted soil 'La Escondida' lagoon in Reynosa,...
Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries worldwide. No vaccine available to prevent the disease, and medical treatments cause serious side effects. Additionally, treatment failure parasite resistance have made development of new drugs against CL necessary. In this work, virtual screening natural products from BIOFACQUIM Selleckchem databases was performed using method molecular docking at triosephosphate isomerase (TIM) enzyme interface...
Tuberculosis continues to be a public health problem in the world, and drug resistance has been major obstacle its treatment. Quinoxaline 1,4-di-N-oxide proposed as scaffold design new drugs combat this disease. To examine efficacy of compound, study evaluates methyl, ethyl, isopropyl, n-propyl esters quinoxaline derivatives vitro against Mycobacterium tuberculosis (pansusceptible monoresistant strains). Additionally, inhibitory effect on M. gyrase supercoiling was examined, stability...
Flourensia cernua is a bush that grows in the semi-desert regions of Mexico. It has been used traditional medicine due to its healing properties and currently represents an alternative source bioactive molecules for different areas agri-food health industries. The objective this study was extract characterize purified polyphenolic compounds (PPCs) essential oils (EOs) F. leaves, determine total flavonoid content, evaluate antioxidant activity by three assays, determine, first time,...
The biological activity of Ruta graveolens leaf tissue extracts obtained with different solvents (ethyl acetate, ethanol, and water) metabolites (psoralen, 2- undecanone rutin) against Spodoptera frugiperda was evaluated. Metabolites levels in were quantified by HPLC GC. Ethyl acetate ethanol showed 94% 78% mortality, respectively. Additionally, psoralen metabolite a high mortality as cypermethrin. Metabolite quantification shows the presence 2-undecanone (87.9 µmoles mg(-1) DW), (3.6 DW)...