A5003735385- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
- Crystallography and molecular interactions
- Receptor Mechanisms and Signaling
- Radioactive element chemistry and processing
- Catalytic Processes in Materials Science
- Neurotransmitter Receptor Influence on Behavior
- Nanomaterials for catalytic reactions
- Carbon dioxide utilization in catalysis
- Neuropeptides and Animal Physiology
- Magnetism in coordination complexes
- Multicomponent Synthesis of Heterocycles
- Membrane Separation Technologies
- Cardiac Imaging and Diagnostics
- Carbon Dioxide Capture Technologies
- Luminescence and Fluorescent Materials
- interferon and immune responses
- Drug Transport and Resistance Mechanisms
- Chemical Reactions and Isotopes
- Synthesis and properties of polymers
- Nanoplatforms for cancer theranostics
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
University of Maryland, College Park
2021-2025
Lawrence Berkeley National Laboratory
2016-2021
University of California, Berkeley
2015-2021
Sandia National Laboratories
2019-2021
Center for Integrated Nanotechnologies
2019-2021
University of California System
2019
Berkeley College
2019
National Center for Advancing Translational Sciences
2013-2014
National Institutes of Health
2013-2014
National Human Genome Research Institute
2013
Technologies that can efficiently purify nontraditional water sources are needed to meet rising global demand for clean water. Water treatment plants typically require a series of costly separation units achieve desalination and the removal toxic trace contaminants such as heavy metals boron. We report robust, selective, tunable adsorptive membranes feature porous aromatic framework nanoparticles embedded within ion exchange polymers demonstrate their use in an efficient, one-step strategy...
Metal–organic frameworks are among the most promising materials for industrial gas separations, including removal of carbon dioxide from natural gas, although substantial improvements in adsorption selectivity still sought. Herein, we use equilibrium experiments to demonstrate that flexible metal–organic framework Co(bdp) (bdp2– = 1,4-benzenedipyrazolate) exhibits a large CO2 capacity and approaches complete exclusion CH4 under 50:50 mixtures two gases, leading outstanding CO2/CH4 these...
Metal-organic frameworks that flex to undergo structural phase changes upon gas adsorption are promising materials for storage and separations, achieving synthetic control over the pressure at which these occur is crucial design of such specific applications. To this end, a new family based on flexible metal-organic framework Co(bdp) (bdp2- = 1,4-benzenedipyrazolate) has been prepared via introduction fluorine, deuterium, methyl functional groups bdp2- ligand, namely, Co(F-bdp),...
Lithium-ion batteries have remained a state-of-the-art electrochemical energy storage technology for decades now, but their densities are limited by electrode materials and conventional liquid electrolytes can pose significant safety concerns. Lithium metal featuring Li anodes, solid polymer electrolytes, high-voltage cathodes represent promising candidates next-generation devices exhibiting improved power safety, such generally do not exhibit the required excellent properties thermal...
Abstract This study demonstrates that functionalized, highly porous polymers are promising for the adsorptive capture of boric acid, a neutral contaminant is difficult to remove from seawater using conventional reverse osmosis membranes. Appending N ‐methyl‐d‐glucamine (NMDG) pore walls high‐surface‐area aromatic frameworks (PAFs) yields adsorbents PAF‐1‐NMDG and P2‐NMDG in simple two‐step synthesis. The boron‐selective PAFs demonstrate adsorption capacities up 70% higher than those...
Metal-organic frameworks that display step-shaped adsorption profiles arising from discrete pressure-induced phase changes are promising materials for applications in both high-capacity gas storage and energy-efficient separations. The thorough investigation of such through chemical diversification, measurements, situ structural characterization is therefore crucial broadening their utility. We examine a series isoreticular, flexible zeolitic imidazolate (ZIFs) the type M(bim)2 (SOD; M = Zn...
Simple and direct determination of iron ion concentrations in water samples is achieved.
An alkene-terminated ligand self-assembles with rare-earth ions, yielding polymerizable cages and subsequently rare-earth-binding polymer networks.
Understanding the structural dynamics of covalent organic frameworks (COFs) in response to external temperature change is necessary for these materials' application at cryogenic temperatures. Herein, we report reversible observed as varies from 298 K 30 K. A series (COF-300, COF-300-amine, and COF-V) was studied
The D2 dopamine receptor (D2 DAR) is one of the most validated drug targets for neuropsychiatric and endocrine disorders. However, clinically approved drugs targeting DAR display poor selectivity between other receptors, especially D3 DAR. This lack may lead to undesirable side effects. Here we describe chemical pharmacological characterization a novel antagonist series with excellent versus D1, D3, D4, D5 selectivity. final probe 65 was obtained through quantitative high-throughput...
Despite their many advantages, covalent organic frameworks (COFs) built from three-dimensional monomers are synthetically difficult to functionalize. Herein, we provide a new synthetic approach the functionalization of framework (COF-300) by using series solid-state linkage transformations. By reducing imine linkages amine linkages, produced more hydrolytically stable material and liberated nucleophilic amino group, poised for further functionalization. We then treated amine-linked COF with...
A facile route to 4,4'-bipyrazole (H2bpz) and other symmetric bipyrazoles is achieved via the palladium-catalyzed homocoupling of a pyrazole boronic ester in presence air water, enabling us provide first crystal structures evidence structural phase changes bipyrazolate-based metal-organic framework Co(bpz).
By controlling the ratio of end groups in a series porous organic polymers, we maximized their cobalt adsorption capacity.
<p>Metal–organic frameworks that display step-shaped adsorption profiles arising from discrete pressure-induced phase changes are promising materials for applications in both high-capacity gas storage and energy-efficient separations. The thorough investigation of such through chemical diversification, measurements, <i>in situ </i>structural characterization is therefore crucial broadening their utility. We examine a series isoreticular, flexible zeolitic imidazolate (ZIFs)...
A templated synthetic approach to porous organic polymers, in which branched, rigid monomers are pre-assembled around a target ion before polymerization, can significantly enhance the adsorption capacity of resulting polymer.