A5009756392- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Estrogen and related hormone effects
Centre de Recherche en Cancérologie de Lyon
2020-2023
Université Claude Bernard Lyon 1
2020-2023
Centre National de la Recherche Scientifique
2020-2023
Centre Léon Bérard
2020-2023
Inserm
2020-2023
Abstract Background High-grade adult-type diffuse gliomas (HGGs) constitute a heterogeneous group of aggressive tumors that are mostly incurable. Recent advances highlighting the contribution ribosomes to cancer development have offered new clinical perspectives. Here, we uncovered isocitrate dehydrogenase (IDH)wt and IDHmut HGGs display distinct alterations ribosome biology, in terms rRNA epitranscriptomics biogenesis, which could novel hallmarks can be exploited for management these...
Resistance of advanced hormone-dependent endometrial carcinoma to endocrine therapy remains a worldwide clinical issue. We recently reported that the combination Vistusertib (V, mTOR inhibitor) and Anastrozole (A, aromatase improves progression-free rate compared alone. However, better patient selection based on biomarkers would improve outcome. evaluate for first time usage ribosome biogenesis (RiBi) factors as source innovative markers. Using 47 FFPE tumours (A n = 18; V + A 29), 32 blood...